HEPATOLOGY Journal

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Overview

publication venue for

• p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling..  78:243-257. 2023
• Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice..  77:1849-1865. 2023
• Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes..  74:1845-1863. 2021
• Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3..  72:1191-1203. 2020
• Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis..  71:990-1008. 2020
• Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury..  72:2219-2227. 2020
• Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity..  68:48-61. 2018
• Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2–/– mice and human cholangiocarcinoma tumorigenesis.  68:1042-1056. 2018
• Novel -catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis..  67:829-832. 2018
• Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis..  65:2045-2058. 2017
• Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice..  65:544-559. 2017
• Pivotal role of glutamine synthetase in ammonia detoxification..  65:281-293. 2017
• Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells..  66:528-541. 2017
• Inhibition of mast cell‐secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2−/− mice.  1202-1216. 2016
• The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-1 biliary secretion in mice..  64:865-879. 2016
• Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis.  61:2018-2029. 2015
• Repurposing an old drug: A low-cost allergy medication provides new hope for hepatitis C patients..  62:1911-1913. 2015
• Cholangiocyte lipoapoptosis: implications for biliary damage during nonalcoholic fatty liver disease..  60:1809-1811. 2014
• GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8..  58:251-263. 2013
• Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats..  57:1130-1141. 2013
• Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice..  56:130-139. 2012
• Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration..  55:209-221. 2012
• Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1..  53:628-639. 2011
• Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes..  52:1819-1828. 2010
• Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation..  52:204-214. 2010
• Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis..  49:1795-1797. 2009
• Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation..  50:244-252. 2009
• Genome-level analysis of genetic regulation of liver gene expression networks..  46:548-557. 2007
• ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice..  46:1620-1631. 2007
• Isoleucine infusion during "simulated" upper gastrointestinal bleeding improves liver and muscle protein synthesis in cirrhotic patients..  45:560-568. 2007
• Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver..  41:336-344. 2005
• Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats..  41:1037-1045. 2005
• Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury..  42:1137-1147. 2005
• Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP..  40:1116-1127. 2004
• Ammonia metabolism in cirrhotic patients with TIPS - Reply.  37:1497-1497. 2003
• Ammonia metabolism in cirrhotic patients with TIPS..  37:1496-1497. 2003
• Induced hyperammonemia alters neuropsychology, brain MR spectroscopy and magnetization transfer in cirrhosis..  37:931-939. 2003
• Is hyperammonemia really the true cause of altered neuropsychology, brain MR spectroscopy and magnetization transfer after an oral amino acid load in cirrhosis?.  38:777-777. 2003
• Is hyperammonemia really the true cause of altered neuropsychology, brain MR spectroscopy and magnetization transfer after an oral amino acid load in cirrhosis? Reply.  38:778-778. 2003
• The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis..  37:1277-1285. 2003
• Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity..  36:641-651. 2002
• Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS..  36:1163-1171. 2002
• Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities..  35:1329-1340. 2002
• Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha..  35:1041-1052. 2002
• Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?.  34:935-942. 2001
• Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes..  34:868-876. 2001
• Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia..  34:50-54. 2001
• Interferon tau–induced hepatocyte apoptosis in sheep.  31:1275-1284. 2000
• Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFkappaB-dependent mechanisms..  32:1050-1059. 2000
• Functional heterogeneity of the intrahepatic biliary epithelium..  31:555-561. 2000
• Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms..  32:17-25. 2000
• The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat..  32:174-184. 2000
• The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat..  31:391-398. 2000
• Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells..  29:737-745. 1999
• Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver..  29:307-319. 1999
• Reduced expression of glutathione S-transferase Yb2 during progression of chemically induced hepatocellular carcinomas in Fischer 344 rats..  20:149-158. 1994
• Metabolic adaptation of the kidney to hyperammonemia during chronic liver insufficiency in the rat..  18:890-902. 1993
• Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen..  16:167-172. 1992
• Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation..  12:281-290. 1990
• Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs..  11:682-689. 1990
• BILIARY SENESCENCE REGULATES NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) PHENOTYPES BY E2F1/FOXO1/IGF-1 SIGNALING 2022
• INFLUENCES OF EXPOSURE TO GULF WAR ILLNESS-RELATED CHEMICALS ON GUT DYSBIOSIS AND HEPATIC CLEARANCE OF TRANSLOCATED PATHOBIONTS IN AGING ASSOCIATED CHRONIC LIVER INJURIES 2022
• INHIBITION OF ALPHA-CALCITONIN GENE-RELATED PEPTIDE (.LPHA-CGRP) SIGNALING ATTENUATES METHIONINE-AND CHOLINE-DEFICIENT DIET (MCD)-INDUCED NONALCOHOLIC STEATOHEPATITIS (NASH) PHENOTYPES 2022
• PROLONGED ADMINISTRATION OF MELATONIN AMELIORATES BILIARY AND LIVER PHENOTYPES IN THE FEMALE MDR2-/- MOUSE MODEL OF PRIMARY SCLEROSING CHOLANGITIS 2022
• HEALTHCARE COSTS AND EXPENDITURES FOR PATIENTS WITH HEPATOCELLULAR CARCINOMA IN THE UNITED STATES 2022
• HUMAN LIVER MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES REDUCE LIVER FIBROSIS THROUGH INHIBITION OF p53-MIR-34a AXIS IN ALD 2022
• FREE FATTY ACIDS-INDUCED ACTIVATION OF THE ALPHA-CALCITONIN GENE-RELATED PEPTIDE (ACGRP)/CALCITONIN RECEPTOR-LIKE RECEPTOR (CRLR)/RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 (RAMP1) AXIS REGULATES MIR-125B EXPRESSION VIA TLR4 IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) 2021
• INHIBITION OF THE SUBSTANCE P/NEUROKININ RECEPTOR (SP/NK1R) AXIS AMELIORATES LIVER PHENOTYPES IN A MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) 2021
• KNOCKOUT OF BILIARY NEUROKININ 1 RECEPTOR (NK1R) AMELIORATES LIVER PHENOTYPES IN ALCOHOL ASSOCIATED LIVER DISEASE (ALD) 2021
• KNOCKOUT OF SECRETIN RECEPTOR (SR) AMELIORATES LIVER PHENOTYPES IN A MOUSE MODEL OF ALCOHOL ASSOCIATED LIVER DISEASE (ALD) 2021
• MELATONIN BINDS MT1 TO IMPROVE THE PHENOTYPES OF PRIMARY SCLEROSING CHOLANGITIS (PSC) THROUGH CLOCK GENES/MIR-200B/MASPIN/GST SIGNALING 2021
• THE AGGRAVATING EFFECTS OF GULF WAR ILLNESS-RELATED CHEMICALS ON HEPATIC STEATOSIS AND ETHANOL-INDUCED CHRONIC LIVER INJURY IN MICE 2021
• MANIPULATION OF THE MIR-16/FGF-1 AXIS REDUCES PROFIBROTIC, PROLIFERATIVE, AND INFLAMMATORY PHENOTYPES IN THE MDR2-/- MOUSE MODEL OF PRIMARY SCLEROSING CHOLANGITIS (PSC) 2020
• THE BILIARY SECRETIN/SECRETIN RECEPTOR (SCT/SR)/MIR-125b AXIS REGULATES HEPATIC STEATOSIS AND LIVER ANGIOGENESIS IN NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) 2020
• LYMPHATIC-CHOLANGIOCARCINOMA INTERACTIONS ALTER TUMOR METABOLISM AND CELLULAR SIGNALING PATHWAYS THAT CONTRIBUTE TO TUMOR PROGRESSION AND METASTASIS 2020
• DISRUPTION OF ADENOSINE 2A RECEPTOR EXACERBATES MCD-INDUCED NASH PHENOTYPE IN MICE 2019
• DOWNREGULATION OF STIMULATOR OF INTERFERON GENES (STING) DECREASES BILIARY SENESCENCE AND LIVER FIBROSIS IN CHOLESTATIC MICE THROUGH A DECREASE EXPRESSION OF tmiR24-3p/MELATONIN/AANAT/PER1 SIGNALING. 2019
• STING EXPRESSION IN MONOCYTE-DERIVED MACROPHAGES IS ASSOCIATED WITH THE PROGRESSION OF LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE 2019
• Knock-out (KO) of Secretin (Sct) Reduces Biliary Senescence, Ductular Reaction, Liver Inflammation, Steatosis and Fibrosis in Mice Fed High-Fat Diet (HFD) through Changes in the miRNA-125b/VEGF-A Axis. 2018
• Pinealectomy or Prolonged Light Exposure Exacerbates Biliary Proliferation and Senescence and Liver Fibrosis in Bile Duct Ligated (BDL) Rats Via Decreased Biliary Melatonin Synthesis. 2018
• Disruption of Myeloid Cell-Specific PFKFB3 Exacerbates Diet-Induced Hepatic Steatosis and Inflammation in Mice 2018
• Exposure to gulf war illness-related chemicals increases susceptibility to cholestatic liver injury by enhancing CD11b+macrophage/monocyte infiltration into the liver 2017
• Hyperammonemia impairs skeletal muscle protein synthesis via a novel Myostatin-ALK5-AMPK dependent mechanism 2016
• Neurocognitive and Health Related Quality Of Life Outcomes in the First Year after Pediatric Acute Liver Failure 2016
• Xenobiotic metabolism in a mouse model of non-alcoholic fatty liver disease: A case study of the ubiquitous environmental contaminant tetrachloroethylene 2016
• Hyperammonemia impairs skeletal muscle protein synthesis via a myostatin dependent mechanism 2015
• Long term oral treatment of ornithine phenylacetate increases lean mass and attenuates brain edema in bile-duct ligated rats. 2015
• Severe liver and kidney injury in mouse models of acute-on-chronic alcoholic hepatitis 2014
• Leucine reverses anabolic resistance of hyperammonemia in cirrhosis: a prospective controlled study 2013
• The PedsQL (TM) Infant Scales in infants with chronic liver disease: Feasibility, Reliability and Validity 2012
• H1 (BUT NOT H3) HISTAMINE RECEPTOR AGONISTS ACCELERATE THE REGROWTH OF THE BILIARY EPITHELIUM FOLLOWING 70% PARTIAL HEPATECTOMY BY INCREASED CHOLANGIOCYTE VEGF EXPRESSION 2009
• GENE EXPRESSION IN NON-TUMORAL LIVER TISSUE AND RISK OF RECURRENCE OF HEPATOCELLULAR CARCINOMA IN HEPATITIS C VIRUS-POSITIVE SUBJECTS 2009
• HEALTH-RELATED QUALITY OF LIFE AFTER PEDIATRIC LIVER TRANSPLANTATION FOR ACUTE LIVER FAILURE: RESULTS FROM THE SPLIT FUNCTIONAL OUTCOMES GROUP 2009
• INCIDENCE OF AFLATOXIN B1-INDUCED HEPATIC TUMORS IS INCREASED IN HEPATITIS VIRUS C TRANSGENIC MICE AS COMPARED TO WILD TYPE C57BL/6J STRAIN 2009
• METHYLATION FREQUENCY OF P16, SOCS-1, RASSF1A, APC AND GSTP1 PROMOTERS IN TUMOROUS, NON-TUMOROUS AND METASTATIC LIVER TUMOR SAMPLES FROM HCV-POSITIVE PATIENTS WITH HCC IN JAPAN 2009
• FOLLICLE STIMULATING HORMONE INCREASES CHOLANGIOCYTE PROLIFERATION OF NORMAL AND BILE DUCT LIGATED (BDL) RATS BY AN AUTOCRINE MECHANISM 2008
• Health related quality of life (HRQOL) in pediatric liver transplant recipients. Preliminary results of the studies of pediatric liver transplantation (SPLIT) functional outcomes group (FOG) 2007
• Metabolomic analysis of urine and liver after chronic alcohol treatment in C57BL/6j mice 2007
• Evidence for marked disturbance in whole body and brain glutamate (GLU) metabolism with no alteration of glutamine II (GLN) metabolism in an acetaminophen induced fulminant hepatic encephalopathy (HE) mouse model 2005
• Neuropsychological and behavioural characterisation of a fully-reversible acetaminophen-induced model of hepatic encephalopathy (HE) in mice 2005
• Arginine, citrulline, and nitric oxide metabolism in patients with liver failure and the effect of intervention with hypothermia, MARS and transplantation. 2004
• Hepatic inflammation exacerbates elevated portal pressure by increasing asymmetric dimethylarginine (ADMA), a regulator of endothelial nitric oxide synthase (eNOS) activity. 2004
• Increased phosphate-activated glutaminase activity contributes substantially to the hyperammonemia in acute liver failure. 2004
• Cytochrome p450 2E1, but not NADPH oxidase is required for ethanol-induced DNA damage and upregulation of DNA repair genes in mouse liver. 2003
• Diminished renal ammonia flux despite induced hyperammonemia after TIPSS placement in patients with cirrhosis of the liver. 2002
• Increased cerebral and peripheral vasodilation following TIPSS is due to increased whole body nitric oxide (NO) production. 2002
• Inflammation significantly exacerbates the effect of hyperammonemia on neurological function in chronic liver disease. 2002
• A rise in cerebral blood flow precedes intracranial hypertension in patients with acute liver failure (ALF). 2001
• Changes in neuropsychological function following hyperammonemia induced by a simulated bleed is mediated by increase in brain water. 2001
• Stimulated liver and muscle protein synthesis by intravenous isoleucine supplementation during a simulated variceal bleed in patients with cirrhosis of the liver. 2001
• Interorgan ammonia metabolism following acute variceal bleeding in patients with cirrhosis of the liver: Hyperammonemia is caused by renal ammonia release 2000
• Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. 2000
• Restoration of cerebral blood flow (CBF) autoregulation and reactivity to carbon dioxide in acute liver failure (ALF) by moderate hypothermia. 2000
• Endothelial cells have a glycine-gated chloride channel 1999
• Enhanced renal ammonia production is major cause of hyperammonemia after a simulated upper gastrointestinal bleed in patients with cirrhosis of the liver 1999
• Interorgan ammonia metabolism in overnight fasted, metabollically stable patients with cirrhosis of the liver. 1999
• Kupffer cell nadph oxidase plays an important role in early alcohol-induced liver injury in mice 1999
• Absence of cori cycling after endotoxin challenge in pigs. 1998
• Changes in cerebral metabolism in patients with acute liver failure (ALF) and uncontrolled intracranial hypertension treated with moderate hypothermia 1998
• Liver increases glucose production, whereas kidney decreases glucose production after endotoxin challenge. 1998
• Role of Kupffer cells and NF kappa B in peroxisome proliferator-induced cell proliferation. 1998
• Simulation of a upper gastrointestinal bleed in patients with cirrhosis of the liver: A model to study the metabolism of hepatic encephalopathy. 1998
• Oxidative stress occurs in perfused rat liver under hypoxic conditions via mechanisms involving peroxynitrite. 1997
• WY-14,643 rapidly activates the nuclear factor kappa B in non-parenchymal cells. 1997
• HYPERAMMONEMIC SYNDROMES IN THE RAT SIMULTANEOUSLY STUDIED BY INVIVO H-1-NMR SPECTROSCOPY (NMRS) AND EEG-SPECTRAL ANALYSIS 1988
• mtDNA RELEASED BY CHOLANGIOCYTES PROMOTES STING ACTIVATION AND FIBROTIC REACTION

Identity

International Standard Serial Number (ISSN)

• 0270-9139