American Society for Pharmacology & Experimental Therapeutics (ASPET) Publisher

publisher of

• Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents..  Journal of Pharmacology and Experimental Therapeutics.  388:260-267. 2024
• Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats-Editorial..  Journal of Pharmacology and Experimental Therapeutics.  388:257-259. 2024
• Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation..  Journal of Pharmacology and Experimental Therapeutics.  jpet-ar-2023-001819. 2023
• Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations and Electrographic Ictal Biomarkers..  Journal of Pharmacology and Experimental Therapeutics.  jpet-ar-2023-001817. 2023
• A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-term Epileptic Seizure Activity, Neurological Dysfunction and Neurodegeneration..  Journal of Pharmacology and Experimental Therapeutics.  jpet-ar-2023-001794. 2023
• Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic..  Journal of Pharmacology and Experimental Therapeutics.  jpet-mr-2023-001816. 2023
• Long-term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids..  Journal of Pharmacology and Experimental Therapeutics.  JPET-AR-2023-001763. 2023
• Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage..  Journal of Pharmacology and Experimental Therapeutics.  JPET-AR-2023-001747. 2023
• RESVERATROL BINDS NUCLEAR RECEPTOR 4A1 (NR4A1) AND ACTS AS AN NR4A1 ANTAGONIST IN LUNG CANCER CELLS..  Molecular Pharmacology.  102:80-91. 2022
• Therapeutic Basis of Generic Substitution of Antiseizure Medications..  Journal of Pharmacology and Experimental Therapeutics.  381:188-196. 2022
• Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions..  Pharmacological Reviews.  74:387-438. 2022
• The Cannabinoid Receptor Type 1 Positive Allosteric Modulator ZCZ011 Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice..  Journal of Pharmacology and Experimental Therapeutics.  380:1-14. 2022
• Inhibiting Sialidase-Induced TGF-1 Activation Attenuates Pulmonary Fibrosis in Mice..  Journal of Pharmacology and Experimental Therapeutics.  376:106-117. 2021
• Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies..  Pharmacological Reviews.  72:767-800. 2020
• Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam..  Journal of Pharmacology and Experimental Therapeutics.  372:285-298. 2020
• Correction to "Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson's Disease"..  Journal of Pharmacology and Experimental Therapeutics.  369:66-66. 2019
• Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate -Arrestin-Dependent Responses..  Molecular Pharmacology.  95:1-10. 2019
• Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents..  Journal of Pharmacology and Experimental Therapeutics.  367:302-321. 2018
• Bortezomib Targets Sp Transcription Factors in Cancer Cells..  Molecular Pharmacology.  94:1187-1196. 2018
• Compensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in Astrocytes..  Molecular Pharmacology.  94:1174-1186. 2018
• NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis..  Journal of Pharmacology and Experimental Therapeutics.  366:46-57. 2018
• 3-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic -Subunit -Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield..  Journal of Pharmacology and Experimental Therapeutics.  365:583-601. 2018
• The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism..  Journal of Pharmacology and Experimental Therapeutics.  365:636-651. 2018
• Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy..  Journal of Pharmacology and Experimental Therapeutics.  364:180-197. 2018
• Epigenetic Histone Deacetylation Inhibition Prevents the Development and Persistence of Temporal Lobe Epilepsy..  Journal of Pharmacology and Experimental Therapeutics.  364:97-109. 2018
• Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells..  Molecular Pharmacology.  91:438-450. 2017
• Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice..  Journal of Pharmacology and Experimental Therapeutics.  361:17-28. 2017
• Circadian Regulation of Benzo[a]Pyrene Metabolism and DNA Adduct Formation in Breast Cells and the Mouse Mammary Gland..  Molecular Pharmacology.  91:178-188. 2017
• Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps..  Journal of Pharmacology and Experimental Therapeutics.  359:110-123. 2016
• Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice..  Journal of Pharmacology and Experimental Therapeutics.  358:50-60. 2016
• Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic GABA(A) Receptors..  Journal of Pharmacology and Experimental Therapeutics.  357:188-204. 2016
• The Pharmacological Basis of Cannabis Therapy for Epilepsy..  Journal of Pharmacology and Experimental Therapeutics.  357:45-55. 2016
• Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes..  Drug Metabolism and Disposition.  43:1536-1543. 2015
• Antiseizure Activity of Midazolam in Mice Lacking -Subunit Extrasynaptic GABA(A) Receptors..  Journal of Pharmacology and Experimental Therapeutics.  353:517-528. 2015
• The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor B..  Molecular Pharmacology.  87:1021-1034. 2015
• (4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs..  Molecular Pharmacology.  87:197-206. 2015
• Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities..  Molecular Pharmacology.  85:777-788. 2014
• Estrous cycle regulation of extrasynaptic -containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis..  Journal of Pharmacology and Experimental Therapeutics.  346:146-160. 2013
• Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease..  Journal of Pharmacology and Experimental Therapeutics.  345:125-138. 2013
• Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels..  Journal of Pharmacology and Experimental Therapeutics.  345:7-14. 2013
• Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization..  Molecular Pharmacology.  83:33-41. 2013
• Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells..  Journal of Pharmacology and Experimental Therapeutics.  343:333-341. 2012
• Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice..  Journal of Pharmacology and Experimental Therapeutics.  343:401-412. 2012
• A mouse kindling model of perimenstrual catamenial epilepsy..  Journal of Pharmacology and Experimental Therapeutics.  341:784-793. 2012
• Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response..  Molecular Pharmacology.  81:759-769. 2012
• 72 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their 7-7 interfaces..  Molecular Pharmacology.  81:175-188. 2012
• ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models..  Journal of Pharmacology and Experimental Therapeutics.  338:134-142. 2011
• Protein kinase CbetaII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (tacrolimus)..  Journal of Pharmacology and Experimental Therapeutics.  337:718-723. 2011
• Correction to Methyl 2-Cyano-3,12-dioxooleana-1, 9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a.  Molecular Pharmacology.  79:336-336. 2011
• Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor..  Journal of Pharmacology and Experimental Therapeutics.  335:172-179. 2010
• Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect. 2010
• The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors..  Journal of Pharmacology and Experimental Therapeutics.  334:1031-1041. 2010
• Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a..  Molecular Pharmacology.  78:226-236. 2010
• Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth..  Molecular Pharmacology.  77:396-404. 2010
• The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor..  Molecular Pharmacology.  76:604-611. 2009
• Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. 2009
• Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis..  Molecular Pharmacology.  75:35-43. 2009
• Lipopolysaccharide increases cell surface P-glycoprotein that exhibits diminished activity in intestinal epithelial cells..  Drug Metabolism and Disposition.  36:2145-2149. 2008
• Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells..  Molecular Pharmacology.  73:553-565. 2008
• Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland..  Molecular Pharmacology.  72:1349-1358. 2007
• 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways..  Molecular Pharmacology.  71:558-569. 2007
• Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice..  Journal of Pharmacology and Experimental Therapeutics.  318:629-640. 2006
• 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1..  Molecular Pharmacology.  68:1782-1792. 2005
• Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins..  Molecular Pharmacology.  68:317-329. 2005
• 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways..  Molecular Pharmacology.  68:119-128. 2005
• Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells..  Journal of Pharmacology and Experimental Therapeutics.  313:855-861. 2005
• Estrogen regulation of the cytochrome P450 3A subfamily in humans..  Journal of Pharmacology and Experimental Therapeutics.  311:728-735. 2004
• Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice..  Journal of Pharmacology and Experimental Therapeutics.  310:230-239. 2004
• Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells..  Molecular Pharmacology.  63:1373-1381. 2003
• Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates..  Journal of Pharmacology and Experimental Therapeutics.  305:394-401. 2003
• Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis..  Journal of Pharmacology and Experimental Therapeutics.  303:904-908. 2002
• Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition..  Journal of Pharmacology and Experimental Therapeutics.  301:1132-1138. 2002
• Identification of albumin precursor protein, Phi AP3, and alpha-smooth muscle actin as novel components of redox sensing machinery in vascular smooth muscle cells..  Molecular Pharmacology.  61:1174-1183. 2002
• Pharmacological separation of the expression of tissue transglutaminase and apoptosis after chemotherapeutic treatment of HepG2 cells..  Molecular Pharmacology.  59:1388-1394. 2001
• Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents..  Molecular Pharmacology.  59:765-773. 2001
• Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells..  Molecular Pharmacology.  59:744-750. 2001
• Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity..  Molecular Pharmacology.  59:170-176. 2001
• Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies..  Molecular Pharmacology.  58:852-858. 2000
• Activation of c-Ha-ras by benzo(a)pyrene in vascular smooth muscle cells involves redox stress and aryl hydrocarbon receptor..  Molecular Pharmacology.  58:152-158. 2000
• Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan..  Molecular Pharmacology.  53:415-421. 1998
• Identification of benzo[a]pyrene-inducible cis-acting elements within c-Ha-ras transcriptional regulatory sequences..  Molecular Pharmacology.  52:974-982. 1997