HR job title
- Associate Professor
- Contact Info
- 1 713 677 7484
- ORCiD
- 0000-0001-5950-9168
Huang, Yun Associate Professor
Positions
- Associate Professor, Institute of Biosciences and Technology, School of Medicine
Dr. Huang is currently an Assistant Professor at the Center for Epigenetics and Disease Prevention, Institute of Biosciences & Technology, Texas A&M University. Her long-term goal is to elucidate the molecular basis of epigenetic changes in the human genome and to develop novel therapies by targeting aberrant DNA methylation and demethylation associated with human diseases, including cancer, immunoinflammatory and cardiovascular diseases.
Dr. Huang's laboratory is focused on elucidating the physiological and pathophysiological functions of TET2 protein and its 5-methylcytosine oxidation products (5hmC, 5fC and 5caC) in cancer and development (Nature Genet 2014; Trends in Genetics 2014).
Dr. Huang's laboratory is focused on elucidating the physiological and pathophysiological functions of TET2 protein and its 5-methylcytosine oxidation products (5hmC, 5fC and 5caC) in cancer and development (Nature Genet 2014; Trends in Genetics 2014).
- Overview
- Publications
- Research
- Teaching
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Overview
Publications
selected publications
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academic article
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Zhou, Y., Jennette, M. R., Ma, G., Kazzaz, S. A., Baraniak, J. H., Nwokonko, R. M., ... Gill, D. L.
(2023).
An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1. Nature Communications.
14(1), 6921.
-
Hong, T., Li, J., Guo, L., Cavalier, M., Wang, T., Dou, Y., ... Huang, Y.
(2023).
TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nature Aging.
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Dou, Y., Chen, R., Liu, S., Lee, Y., Jing, J. i., Liu, X., ... Huang, Y.
(2023).
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy. Nature Communications.
14(1), 5461.
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Zhao, S., Li, J., Zhang, H., Qi, L., Du, Y., Kogiso, M., ... Li, X.
(2022).
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas. 13(1), 7871.
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Lan, T., He, L., Huang, Y., & Zhou, Y.
(2022).
Optogenetics for transcriptional programming and genetic engineering. Trends in Genetics.
38(12), 1253-1270.
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Zhao, S., Li, J., Zhang, H., Qi, L., Du, Y., Kogiso, M., ... Li, X.
(2022).
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas. Nature Communications.
13(1), 6689.
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Li, J., Hong, T., Wei, Y., Guo, L., Lee, M., Yang, H., ... Huang, Y.
(2022).
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms. Clinical Epigenetics.
14(1), 81.
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Li, J., Wu, X., Ke, J., Lee, M., Lan, Q., Li, J., ... Xie, R.
(2022).
TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation. Nature Communications.
13(1), 3907.
-
Guo, L., Lee, Y., Zhou, Y., & Huang, Y.
(2022).
Targeting epigenetic regulatory machinery to overcome cancer therapy resistance. Seminars in Cancer Biology.
83, 487-502.
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Fang, S., Cui, D., Hong, T., Guo, L., Lee, Y., Lee, M., ... Huang, Y.
(2022).
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells. Stem Cells.
40(3), 260-272.
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Gu, T., Hao, D., Woo, J., Huang, T., Guo, L., Lin, X., ... Goodell, M. A.
(2022).
The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development. Nature Genetics.
54(5), 625-636.
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Yang, J., Horton, J. R., Akdemir, K. C., Li, J., Huang, Y., Kumar, J., ... Cheng, X.
(2021).
Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations. Nucleic Acids Research (NAR).
49(9), 5084-5094.
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He, L., Tan, P., Zhu, L., Huang, K., Nguyen, N. T., Wang, R., ... Zhou, Y.
(2021).
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nature Chemical Biology.
17(8), 915-923.
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He, L., Wang, L., Zeng, H., Tan, P., Ma, G., Zheng, S., ... Zhou, Y.
(2021).
Engineering of a bona fide light-operated calcium channel. Nature Communications.
12(1), 164.
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Nguyen, N. T., Huang, K., Zeng, H., Jing, J. i., Wang, R., Fang, S., ... Zhou, Y.
(2021).
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nature Nanotechnology.
16(12), 1424-1434.
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Kumar, J., Kaur, G., Ren, R., Lu, Y., Lin, K., Li, J., ... Cheng, X.
(2020).
KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. NAR Cancer.
2(2), zcaa007.
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Jing, J. i., Liu, G., Huang, Y., & Zhou, Y.
(2020).
A molecular toolbox for interrogation of membrane contact sites. Journal of Physiology.
598(9), 1725-1739.
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Zhang, X., Wang, X., Wang, X., Su, J., Putluri, N., Zhou, T., ... Goodell, M. A.
(2020).
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis. Blood.
135(11), 845-856.
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Guo, L., Li, J., Zeng, H., Guzman, A. G., Li, T., Lee, M., ... Huang, Y.
(2020).
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nature Communications.
11(1), 740.
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Chen, R., Jing, J. i., Siwko, S., Huang, Y., & Zhou, Y.
(2020).
Intelligent cell-based therapies for cancer and autoimmune disorders. Current Opinion in Biotechnology.
66, 207-216.
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Ma, G., He, L., Liu, S., Xie, J., Huang, Z., Jing, J. i., ... Zhou, Y.
(2020).
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nature Communications.
11(1), 1039.
-
Haruehanroengra, P., Zheng, Y. Y., Zhou, Y., Huang, Y., & Sheng, J.
(2020).
RNA modifications and cancer. RNA Biology.
17(11), 1560-1575.
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Li, J., Zhao, S., Lee, M., Yin, Y., Li, J., Zhou, Y., ... Sun, D.
(2020).
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science Advances.
6(42), eabb5427.
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Yang, J., Horton, J. R., Li, J., Huang, Y., Zhang, X., Blumenthal, R. M., & Cheng, X.
(2019).
Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Research (NAR).
47(16), 8375-8387.
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Yang, J., Horton, J. R., Wang, D., Ren, R., Li, J., Sun, D., ... Cheng, X.
(2019).
Structural basis for effects of CpA modifications on C/EBP binding of DNA. Nucleic Acids Research (NAR).
47(4), 1774-1785.
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Zeng, H., He, H., Guo, L., Li, J., Lee, M., Han, W., ... Huang, Y.
(2019).
Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies. Cancer Letters.
467, 1-8.
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Fang, S., Li, J., Xiao, Y., Lee, M., Guo, L., Han, W., ... Huang, Y.
(2019).
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nature Communications.
10(1), 4297.
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Zhang, J., Tan, P., Guo, L., Gong, J., Ma, J., Li, J., ... Huang, Y.
(2019).
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene.
38(11), 1905-1919.
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Ma, G., Zhang, Q., He, L., Nguyen, N. T., Liu, S., Gong, Z., Huang, Y., & Zhou, Y.
(2018).
Genetically encoded tags for real time dissection of protein assembly in living cells. Chemical Science.
9(25), 5551-5555.
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Nguyen, N. T., He, L., Martinez-Moczygemba, M., Huang, Y., & Zhou, Y.
(2018).
Rewiring Calcium Signaling for Precise Transcriptional Reprogramming. ACS Synthetic Biology.
7(3), 814-821.
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Nguyen, N. T., Ma, G., Lin, E., D'Souza, B., Jing, J. i., He, L., Huang, Y., & Zhou, Y.
(2018).
CRAC channel-based optogenetics. Cell Calcium.
75, 79-88.
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Zheng, S., Zhou, L., Ma, G., Zhang, T., Liu, J., Li, J., ... Wang, Y.
(2018).
Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines. Pfluegers Archiv: European journal of physiology.
470(10), 1555-1567.
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Li, J., Wu, X., Zhou, Y., Lee, M., Guo, L., Han, W., ... Huang, Y.
(2018).
Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC. Nucleic Acids Research (NAR).
46(6), 2883-2900.
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Nguyen, N. T., Han, W., Cao, W., Wang, Y., Wen, S., Huang, Y., ... Zhou, Y.
(2018).
Store-Operated Calcium Entry Mediated byORAIand STIM. Comprehensive Physiology.
8(3), 981-1002.
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Zhang, P., Xiao, Z., Wang, S., Zhang, M., Wei, Y., Hang, Q., ... Ma, L. i.
(2018).
ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Reports.
23(3), 823-837.
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Zang, S., Li, J., Yang, H., Zeng, H., Han, W., Zhang, J., ... Huang, Y.
(2017).
Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis. Journal of Clinical Investigation.
127(8), 2998-3012.
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Huang, A., Wu, H., Iriyama, T., Zhang, Y., Sun, K., Song, A., ... Xia, Y.
(2017).
Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia. HYPERTENSION.
70(1), 209-218.
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Ma, G., Zheng, S., Ke, Y., Zhou, L., He, L., Huang, Y., Wang, Y., & Zhou, Y.
(2017).
Molecular Determinants for STIM1 Activation During Store- Operated Ca2+ Entry. Current Molecular Medicine.
17(1), 60-69.
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Lee, M., Li, J., Liang, Y. i., Ma, G., Zhang, J., He, L., ... Huang, Y.
(2017).
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling. Journal of the American Chemical Society.
139(13), 4659-4662.
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Ma, G., Wen, S., He, L., Huang, Y., Wang, Y., & Zhou, Y.
(2017).
Optogenetic toolkit for precise control of calcium signaling. Cell Calcium.
64, 36-46.
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Yue, X., Trifari, S., ij, T., Tsagaratou, A., Pastor, W. A., Zepeda-Martnez, J. A., ... Rao, A.
(2016).
Control of Foxp3 stability through modulation of TET activity. 213(3), 377-397.
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ij, T., Huang, Y., Mannerstrm, H., Chavez, L., Tsagaratou, A., Rao, A., & Lhdesmki, H.
(2016).
A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways. 17(1), 49.
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Zhang, X., Su, J., Jeong, M., Ko, M., Huang, Y., Park, H. J., ... Goodell, M. A.
(2016).
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nature Genetics.
48(9), 1014-1023.
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Jing, J. i., He, L., Sun, A., Quintana, A., Ding, Y., Ma, G., ... Zhou, Y.
(2015).
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca influx. Nature Cell Biology.
17(10), 1339-1347.
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Etchegaray, J., Chavez, L., Huang, Y., Ross, K. N., Choi, J., Martinez-Pastor, B., ... Mostoslavsky, R.
(2015).
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nature Cell Biology.
17(5), 545-557.
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He, L., Zhang, Y., Ma, G., Tan, P., Li, Z., Zang, S., ... Zhou, Y.
(2015).
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife.
4, e10024.
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Chavez, L., Huang, Y., Luong, K., Agarwal, S., Iyer, L. M., Pastor, W. A., ... Rao, A.
(2014).
Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea. Proceedings of the National Academy of Sciences of the United States of America.
111(48), E5149-E5158.
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Tsagaratou, A., ij, T., Lio, C., Yue, X., Huang, Y., Jacobsen, S. E., Lhdesmki, H., & Rao, A.
(2014).
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation. Proceedings of the National Academy of Sciences of the United States of America.
111(32), E3306-E3315.
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Zhang, C., Huang, Y., Jiang, Y., Mulpuri, N., Wei, L., Hamelberg, D., Brown, E. M., & Yang, J. J.
(2014).
Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium. 289(8), 5296-5309.
-
Huang, Y., & Rao, A.
(2014).
Connections between TET proteins and aberrant DNA modification in cancer. Trends in Genetics.
30(10), 464-474.
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Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G. A., Rodriguez, B., ... Goodell, M. A.
(2014).
Large conserved domains of low DNA methylation maintained by Dnmt3a. Nature Genetics.
46(1), 17-23.
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Huang, Y., Chavez, L., Chang, X., Wang, X., Pastor, W. A., Kang, J., ... Rao, A.
(2014).
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America.
111(4), 1361-1366.
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Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., ... Ecker, J. R.
(2013).
Global epigenomic reconfiguration during mammalian brain development. Science.
341(6146), 1237905-+.
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Cingolani, P., Cao, X., Khetani, R. S., Chen, C., Coon, M., Sammak, A., ... Ruden, D. M.
(2013).
Intronic non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees. BMC GENOMICS.
14(1), 666.
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Vincent, J. J., Huang, Y., Chen, P., Feng, S., Calvopia, J. H., Nee, K., ... Clark, A. T.
(2013).
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell.
12(4), 470-478.
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Huang, Y., & Rao, A.
(2012).
New functions for DNA modifications by TET-JBP. Nature Structural and Molecular Biology.
19(11), 1061-1064.
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Pastor, W. A., Huang, Y., Henderson, H. R., Agarwal, S., & Rao, A.
(2012).
The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols.
7(10), 1909-1917.
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Huang, Y., Pastor, W. A., Zepeda-Martnez, J. A., & Rao, A.
(2012).
The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols.
7(10), 1897-1908.
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Jankowska, A. M., Makishima, H., Tiu, R. V., Szpurka, H., Huang, Y., Traina, F., ... Maciejewski, J. P.
(2011).
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood.
118(14), 3932-3941.
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Tang, S., Wong, H., Wang, Z., Huang, Y., Zou, J., Zhuo, Y., ... Yang, J. J.
(2011).
Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments. Proceedings of the National Academy of Sciences of the United States of America.
108(39), 16265-16270.
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Pastor, W. A., Pape, U. J., Huang, Y., Henderson, H. R., Lister, R., Ko, M., ... Rao, A.
(2011).
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature.
473(7347), 394-397.
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Koh, K. P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., ... Rao, A.
(2011).
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell.
8(2), 200-213.
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Huang, Y., Zhou, Y., Wong, H., Castiblanco, A., Chen, Y., Brown, E. M., & Yang, J. J.
(2010).
Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression. Journal of Biological Chemistry.
285(46), 35919-35931.
-
Jiang, Y., Huang, Y., Wong, H., Zhou, Y., Wang, X., Yang, J., ... Yang, J. J.
(2010).
Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation. Journal of Biological Chemistry.
285(43), 33463-33474.
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Zhou, Y., Tzeng, W., Wong, H., Ye, Y., Jiang, J., Chen, Y., ... Yang, J. J.
(2010).
Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain. Journal of Biological Chemistry.
285(12), 8855-8868.
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Ko, M., Huang, Y., Jankowska, A. M., Pape, U. J., Tahiliani, M., Bandukwala, H. S., ... Rao, A.
(2010).
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature.
468(7325), 839-843.
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Zhou, Y., Meraner, P., Kwon, H. T., Machnes, D., Oh-hora, M., Zimmer, J., ... Hogan, P. G.
(2010).
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nature Structural and Molecular Biology.
17(1), 112-116.
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Huang, Y., Pastor, W. A., Shen, Y., Tahiliani, M., Liu, D. R., & Rao, A.
(2010).
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS ONE.
5(1), e8888-e8888.
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Huang, Y., Zhou, Y., Wong, H., Chen, Y., Chen, Y., Wang, S., ... Yang, J. J.
(2009).
A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+. The FEBS Journal.
276(19), 5589-5597.
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Chen, N., Huang, Y., Yang, L., Liu, R., & Yang, J. J.
(2009).
Designing caspase-3 sensors for imaging of apoptosis in living cells. Chemistry - A European Journal.
15(37), 9311-9314.
-
Chen, N., Zou, J., Wang, S., Ye, Y., Huang, Y., Gadda, G., & Yang, J. J.
(2009).
Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells. Biochemistry.
48(15), 3519-3526.
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Zhou, Y., Tzeng, W., Ye, Y., Huang, Y., Li, S., Chen, Y., Frey, T. K., & Yang, J. J.
(2009).
A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication. Biochemical Journal.
417(2), 477-483.
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Zhou, Y., Yang, W., Lurtz, M. M., Chen, Y., Jiang, J., Huang, Y., Louis, C. F., & Yang, J. J.
(2009).
Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions. Biophysical Journal.
96(7), 2832-2848.
-
Wang, H., Gao, X., Huang, Y., Yang, J., & Liu, Z.
(2009).
P68 RNA helicase is a nucleocytoplasmic shuttling protein. Cell Research.
19(12), 1388-1400.
-
Huang, Y., Zhou, Y., Castiblanco, A., Yang, W., Brown, E. M., & Yang, J. J.
(2009).
Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response. Biochemistry.
48(2), 388-398.
-
Zhou, Y., Yang, W., Lurtz, M. M., Ye, Y., Huang, Y., Lee, H., ... Yang, J. J.
(2007).
Identification of the calmodulin binding domain of connexin 43. Journal of Biological Chemistry.
282(48), 35005-35017.
-
Zou, J., Hofer, A. M., Lurtz, M. M., Gadda, G., Ellis, A. L., Chen, N., ... Yang, J. J.
(2007).
Developing sensors for real-time measurement of high Ca2+ concentrations. Biochemistry.
46(43), 12275-12288.
-
Huang, Y., Zhou, Y., Yang, W., Butters, R., Lee, H., Li, S., ... Yang, J. J.
(2007).
Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor. Journal of Biological Chemistry.
282(26), 19000-19010.
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Huang, Y., Yu, Y., & Yang, J.
(2005).
[Current progress in study of sphingolipids]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
34(4), 375-379.
-
Huang, Y., Shen, J., Wang, T., Yu, Y., Chen, F. F., & Yang, J.
(2005).
A lipidomic study of the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta Biochimica et Biophysica Sinica.
37(8), 515-524.
-
Gao, Z., Yang, J., Huang, Y., & Yu, Y.
(2005).
N-methyl-N'-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
570(2), 175-184.
-
Huang, Y., Yang, J., Shen, J., Chen, F. F., & Yu, Y.
(2005).
Sphingolipids are involved in N-methyl-N'-nitro-N-nitrosoguanidine-induced epidermal growth factor receptor clustering. Biochemical and Biophysical Research Communications.
330(2), 430-438.
-
Huang, Y., Ha, X., & Wu, C.
(2004).
[Protective effects of adenovirus-mediated hepatocyte growth factor on injury of rat cortex neurons]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
20(2), 156-160.
-
Yang, J., Xu, Z., Huang, Y., Hamrick, H. E., Duerksen-Hughes, P. J., & Yu, Y.
(2004).
ATM and ATR: sensing DNA damage. WORLD JOURNAL OF GASTROENTEROLOGY.
10(2), 155-160.
-
Zhou, Y., Jennette, M. R., Ma, G., Kazzaz, S. A., Baraniak, J. H., Nwokonko, R. M., ... Gill, D. L.
(2023).
An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1. Nature Communications.
14(1), 6921.
-
chapter
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Ma, G., He, L., Jing, J. i., Tan, P., Huang, Y., & Zhou, Y.
(2018).
Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel. Methods in molecular biology (Clifton, N.J.).
CRAC CHANNEL: METHODS AND PROTOCOLS.
(pp. 147-166).
Springer Nature.
-
He, L., Zhang, Q., Zhou, Y., & Huang, Y.
(2017).
Calcium Entry Channels in Non-Excitable Cells. Kozak, J. A., & Putney, J. W. (Eds.),
Calcium Entry Channels in Non-Excitable Cells.
(pp. 145-160).
CRC Press.
-
Ma, G., Wen, S., Huang, Y., & Zhou, Y.
(2017).
The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels. Advances in Experimental Medicine and Biology.
STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION.
(pp. 117-138).
Springer Nature.
-
Ma, G., He, L., Jing, J. i., Tan, P., Huang, Y., & Zhou, Y.
(2018).
Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel. Methods in molecular biology (Clifton, N.J.).
CRAC CHANNEL: METHODS AND PROTOCOLS.
(pp. 147-166).
Springer Nature.
-
conference paper
-
Lee, M., Li, J., Li, J., Fang, S., Zhang, J., Vo, A., ... Huang, Y.
(2021).
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes. Cancer Research.
1965-1976.
-
Lee, M., Li, J., Li, J., Fang, S., Zhang, J., Vo, A., ... Huang, Y.
(2021).
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes. Cancer Research.
1965-1976.
-
institutional repository document
-
Lee, M., Li, J., Fang, S., Zhang, J., Vo, A., Han, W., ... Huang, Y.
(2020).
Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes (TILs) to curtail melanoma growth
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Lee, M., Li, J., Fang, S., Zhang, J., Vo, A., Han, W., ... Huang, Y.
(2020).
Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes (TILs) to curtail melanoma growth
Research
principal investigator on
- Role of TET dioxygenase associated immune mechanisms in cardiac injury and repair awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2023
- TET-Mediated Epigenetic Regulation in Cardiac Development awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Molecular toolkit for single-cell oxi-mC analysis awarded by National Institute of General Medical Sciences - (Bethesda, Maryland, United States) 2020 - 2022
- Role of TET proteins during cardiac lineage specification awarded by American Heart Association - (New York, New York, United States) 2016 - 2017
co-principal investigator on
investigator on
Teaching
teaching activities
- IBST605 Biomed Rsrch Prfsnl Dvlpmnt Instructor
- IBST691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2009
- B.M., Zhejiang University - (Hangzhou, Zhejiang, China) 2003
Contact
first name
- Yun
has last name
- Huang
mailing address
-
Texas A&M Health Science Center
Ibt - Cedp - Dashwood
1201 TAMUS
Houston, TX 77030-3303
USA
Other
In the News
- Highly effective tumor detection strategy for common childhood brain tumors News Release
- Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma News Release
- Scientists Develop Highly Effective Detection Strategy For Childhood Brain Tumors News Release
- yun.huang@tamu.edu