HR job title
- Retired Professor
- Contact Info
- 1 979 436 0752
Zimmer, Warren Scott Exter Professor
Positions
- Scott Exter Professor, Medical Physiology, School of Medicine
Our research interests are directed towards understanding the complex mechanisms which regulate the expression of specific gene sequences in development. We have focused our studies upon the factors that influence the smooth muscle component of the developing gastrointestinal (G.I.) tract. It has been shown that smooth muscle cells are predominantly derived from mesodermal precursor cells, however the factors regulating the selection of the smooth muscle myogenic pathway is not well defined.
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Overview
Publications
selected publications
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academic article
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Hammerle, C. M., Sandovici, I., Brierley, G. V., Smith, N. M., Zimmer, W. E., Zvetkova, I., ... Constncia, M.
(2020).
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLOS Genetics.
16(10), e1009069-e1009069.
-
Abbasgholizadeh, R., Zhang, H., Craft, J. W., Bryan, R. M., Bark, S. J., Briggs, J. M., ... Schwartz, R. J.
(2019).
Discovery of vascular Rho kinase (ROCK) inhibitory peptides. Experimental Biology and Medicine.
244(11), 940-951.
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Doersch, K. M., Moses, K. A., & Zimmer, W. E.
(2016).
Synergistic immunologic targets for the treatment of prostate cancer. Experimental Biology and Medicine.
241(17), 1900-1910.
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Goodman, S. R., Petrofes Chapa, R., & Zimmer, W. E.
(2015).
Spectrin's chimeric E2/E3 enzymatic activity. Experimental Biology and Medicine.
240(8), 1039-1049.
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Fillmore, R. A., Kojima, C., Johnson, C., Kolcun, G., Dangott, L. J., & Zimmer, W. E.
(2014).
New concepts concerning prostate cancer screening. Experimental Biology and Medicine.
239(7), 793-804.
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Papke, C. L., Cao, J., Kwartler, C. S., Villamizar, C., Byanova, K. L., Lim, S., ... Milewicz, D. M.
(2013).
Smooth muscle hyperplasia due to loss of smooth muscle -actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-. Human Molecular Genetics.
22(15), 3123-3137.
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Landsman, L., Nijagal, A., Whitchurch, T. J., Vanderlaan, R. L., Zimmer, W. E., Mackenzie, T. C., & Hebrok, M.
(2011).
Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLOS Biology.
9(9), e1001143-e1001143.
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Armstrong, J. J., Larina, I. V., Dickinson, M. E., Zimmer, W. E., & Hirschi, K. K.
(2010).
Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle alpha-actin gene. Genesis: The Journal of Genetics and Development.
48(7), 457-463.
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Kojima, C., Zhang, Y., & Zimmer, W. E.
(2010).
Intronic DNA elements regulate androgen-dependent expression of the murine Nkx3.1 gene. Gene Expression: International Journal of Molecular and Cellular Science.
15(2), 89-102.
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Sun, Q., Taurin, S., Sethakorn, N., Long, X., Imamura, M., Wang, D., ... Miano, J. M.
(2009).
Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. Journal of Biological Chemistry.
284(47), 32582-32590.
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Yang, J., Park, Y., Zhang, H., Gao, X., Wilson, E., Zimmer, W., Abbott, L., & Zhang, C.
(2009).
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology.
297(4), H1208-H1216.
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Verzi, M. P., Stanfel, M. N., Moses, K. A., Kim, B., Zhang, Y., Schwartz, R. J., Shivdasani, R. A., & Zimmer, W. E.
(2009).
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. 136(5), 1701-1710.
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Young, J. L., Zimmer, W. E., & Dean, D. A.
(2008).
Smooth muscle-specific gene delivery in the vasculature based on restriction of DNA nuclear import. Experimental Biology and Medicine.
233(7), 840-848.
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Zhang, Y., Fillmore, R. A., & Zimmer, W. E.
(2008).
Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor. Experimental Biology and Medicine.
233(3), 297-309.
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Akintola, A. D., Crislip, Z. L., Catania, J. M., Chen, G., Zimmer, W. E., Burghardt, R. C., & Parrish, A. R.
(2008).
Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney. American Journal of Physiology: Renal Physiology.
294(1), F170-F176.
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Sampson, H. W., Dearman, A. C., Akintola, A. D., Zimmer, W. E., & Parrish, A. R.
(2007).
Immunohistochemical localization of cadherin and catenin adhesion molecules in the murine growth plate. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology.
55(8), 845-852.
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Stanfel, M. N., Moses, K. A., Carson, J. A., Zimmer, D. B., DeMayo, F., Schwartz, R. J., & Zimmer, W. E.
(2006).
Expression of an Nkx3.1-CRE gene using ROSA26 reporter mice. Genesis: The Journal of Genetics and Development.
44(11), 550-555.
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Stanfel, M. N., Moses, K. A., Schwartz, R. J., & Zimmer, W. E.
(2005).
Regulation of organ development by the NKX-homeodomain factors: an NKX code. Cellular and Molecular Biology.
Suppl 51, OL785-OL799.
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Hsu, Y. J., Zimmer, W. E., & Goodman, S. R.
(2005).
Erythrocyte spectrin's chimeric E2/E3 ubiquitin conjugating/ligating activity. Cellular and Molecular Biology.
51(2), 187-193.
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Takamoto, N., You, L., Moses, K., Chiang, C., Zimmer, W. E., Schwartz, R. J., ... Tsai, S. Y.
(2005).
COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development (Cambridge).
132(9), 2179-2189.
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Vlahopoulos, S., Zimmer, W. E., Jenster, G., Belaguli, N. S., Balk, S. P., Brinkmann, A. O., ... Schwartz, R. J.
(2005).
Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene. Journal of Biological Chemistry.
280(9), 7786-7792.
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Dean, D. A., Strong, D. D., & Zimmer, W. E.
(2005).
Nuclear entry of nonviral vectors. Gene Therapy (Basingstoke).
12(11), 881-890.
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Carson, J. A., Culberson, D. E., Thompson, R. W., Fillmore, R. A., & Zimmer, W.
(2003).
Smooth muscle gamma-actin promoter regulation by RhoA and serum response factor signaling. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
1628(2), 133-139.
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Filmore, R. A., Dean, D. A., & Zimmer, W. E.
(2002).
The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia. Gene Expression: International Journal of Molecular and Cellular Science.
10(5-6), 201-211.
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Hirschi, K. K., Lai, L., Belaguli, N. S., Dean, D. A., Schwartz, R. J., & Zimmer, W. E.
(2002).
Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor. Journal of Biological Chemistry.
277(8), 6287-6295.
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Kakhniashvili, D. G., Chaudhary, T., Zimmer, W. E., Bencsath, F. A., Jardine, I., & Goodman, S. R.
(2001).
Erythrocyte spectrin is an E2 ubiquitin conjugating enzyme. Biochemistry.
40(38), 11630-11642.
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Goodman, S. R., Kakhniashvili, D. G., Sangerman, J., Chaudhary, T., Zimmer, W. E., Bencsath, F. A., & Jardine, I.
(2001).
Erythrocyte Spectrin Is An E2 Ubiquitin Conjugating Enzyme. Cellular and Molecular Biology Letters: an international journal.
6(2), 205.
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Carson, J. A., Fillmore, R. A., Schwartz, R. J., & Zimmer, W. E.
(2000).
The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor. Journal of Biological Chemistry.
275(50), 39061-39072.
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Zagon, I. S., Verderame, M. F., Zimmer, W. E., & McLaughlin, P. J.
(2000).
Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse. 84(1-2), 106-114.
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Zimmer, W. E., Zhao, Y., Sikorski, A. F., Critz, S. D., Sangerman, J., Elferink, L. A., Xu, X. S., & Goodman, S. R.
(2000).
The domain of brain beta-spectrin responsible for synaptic vesicle association is essential for synaptic transmission. BRAIN RESEARCH.
881(1), 18-27.
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Fillmore, R. A., & Zimmer, W. E.
(2000).
Identification of mRNA encoding homeobox proteins hox b4 and Hox b5 in developing chicken gizzard tissues. Cellular and Molecular Biology Letters: an international journal.
5(4), 495-509.
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Vacik, J., Dean, B. S., Zimmer, W. E., & Dean, D. A.
(1999).
Cell-specific nuclear import of plasmid DNA. Gene Therapy (Basingstoke).
6(6), 1006-1014.
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Kovacs, A. M., & Zimmer, W. E.
(1998).
Cell-specific transcription of the smooth muscle gamma-actin gene requires both positive- and negative-acting cis elements. 7(2), 115-129.
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Bao, L., Varden, C. E., Zimmer, W. E., & Balczon, R.
(1998).
Localization of autoepitopes on the PCM-1 autoantigen using scleroderma sera with autoantibodies against the centrosome. Molecular Biology Reports.
25(2), 111-119.
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Browning, C. L., Culberson, D. E., Aragon, I. V., Fillmore, R. A., Croissant, J. D., Schwartz, R. J., & Zimmer, W. E.
(1998).
The developmentally regulated expression of serum response factor plays a key role in the control of smooth muscle-specific genes. Developmental Biology.
194(1), 18-37.
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Zimmer, D. B., Chessher, J., Wilson, G. L., & Zimmer, W. E.
(1997).
S100A1 and S100B expression and target proteins in type I diabetes. ENDOCRINOLOGY.
138(12), 5176-5183.
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Clark, M. B., Ma, Y., Bloom, M. L., Barker, J. E., Zagon, I. S., Zimmer, W. E., & Goodman, S. R.
(1995).
Corrigendum to brain erthroid spectrin: identification, compartmentalization, and spectrin associations [Brain Res. 663 (1994) 223236] (BRES 10639). Brain Research.
700(1-2), 308-308.
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Balczon, R., Bao, L., Zimmer, W. E., Brown, K., Zinkowski, R. P., & Brinkley, B. R.
(1995).
Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells. The Journal of Cell Biology.
130(1), 105-115.
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Ma, Y., Zimmer, W. E., Riederer, B. M., & Goodman, S. R.
(1995).
The complete amino acid sequence for brain spectrin ( fodrin): relationship to globin sequences (Mol. brain Res. 18 (1993)_87-99) (BRESM 70581) (PII:0169-328X(93)90176-P). 30(1), 176.
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Bao, L., Zimmer, W. E., & Balczon, R.
(1995).
Autoepitope mapping of the centrosome autoantigen PCM-1 using scleroderma sera with anticentrosome autoantibodies. Autoimmunity.
22(4), 219-228.
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Goodman, S. R., Zimmer, W. E., Clark, M. B., Zagon, I. S., Barker, J. E., & Bloom, M. L.
(1995).
Brain spectrin: of mice and men. Brain Research Bulletin.
36(6), 593-606.
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Lengeling, A., Zimmer, W. E., Goodman, S. R., Ma, Y., Bloom, M. L., Bruneau, G., ... Jockusch, H.
(1994).
Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11. MAMMALIAN GENOME.
5(3), 163-166.
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Balczon, R., Bao, L., & Zimmer, W. E.
(1994).
PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. The Journal of Cell Biology.
124(5), 783-793.
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Clark, M. B., Ma, Y., Bloom, M. L., Barker, J. E., Zagon, I. S., Zimmer, W. E., & Goodman, S. R.
(1994).
Brain alpha erythroid spectrin: identification, compartmentalization, and beta spectrin associations. BRAIN RESEARCH.
663(2), 223-236.
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Ma, Y., Zimmer, W. E., Riederer, B. M., Bloom, M. L., Barker, J. E., & Goodman, S. R.
(1994).
Corrigendum. Brain Research.
21(1-2), 181-181.
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Ma, Y., Zimmer, W. E., Riederer, B. M., Bloom, M. L., Barker, J. E., & Goodman, S. R.
(1994).
Erratum: The complete amino acid sequence for brain spectrin ( fo;drin): Relationship to globin sequences (Molecular Brain Research (1993) (87-99)). 21(1-2), 181.
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Warren, J. C., Murdock, G. L., Ma, Y., Goodman, S. R., & Zimmer, W. E.
(1993).
Molecular cloning of testicular 20 alpha-hydroxysteroid dehydrogenase: identity with aldose reductase. Biochemistry.
32(6), 1401-1406.
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Ma, Y., Zimmer, W. E., Riederer, B. M., Bloom, M. L., Barker, J. E., Goodman, S. M., & Goodman, S. R.
(1993).
The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences. 18(1-2), 87-99.
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Ma, Y., Zimmer, W. E., Riederer, B. M., Bloom, M. L., Barker, J. E., & Goodman, S. M.
(1993).
Erratum: The complete amino acid sequence for brain spectrin ( fodrin): Relationship to globin sequences (Molecular Brain Research, 18 (1993) (87-99)). 20(1-2), 179.
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Kovacs, A. M., & Zimmer, W. E.
(1993).
Molecular cloning and expression of the chicken smooth muscle gamma-actin mRNA. Cytoskeleton.
24(1), 67-81.
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Thompson, M. E., Zimmer, W. E., Haynes, A. L., Valentine, D. L., Forss-Petter, S., & Scammell, J. G.
(1992).
Prolactin granulogenesis is associated with increased secretogranin expression and aggregation in the Golgi apparatus of GH4C1 cells. ENDOCRINOLOGY.
131(1), 318-326.
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Bloom, M. L., Lee, B. K., Birkenmeier, C. S., Ma, Y., Zimmer, W. E., Goodman, S. R., Eicher, E. M., & Barker, J. E.
(1992).
Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11. MAMMALIAN GENOME.
3(5), 293-295.
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Collinge, M., Matrisian, P. E., Zimmer, W. E., Shattuck, R. L., Lukas, T. J., Van Eldik, L. J., & Watterson, D. M.
(1992).
Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. 12(5), 2359-2371.
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Zimmer, W. E., Ma, Y., Zagon, I. S., & Goodman, S. R.
(1992).
Developmental expression of brain beta-spectrin isoform messenger RNAs. BRAIN RESEARCH.
594(1), 75-83.
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Thompson, M. E., Zimmer, W. E., Wear, L. B., MacMillan, L. A., Thompson, W. J., Huttner, W. B., Hidaka, H., & Scammell, J. G.
(1992).
Differential regulation of chromogranin B/secretogranin I and secretogranin II by forskolin in PC12 cells. 12(1-3), 195-202.
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Zimmer, W. E., Zagon, I. S., Casoria, L. A., & Goodman, S. R.
(1992).
Identification of an amelin isoform located in axons. BRAIN RESEARCH.
582(1), 94-100.
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Zimmer, W. E., Ma, Y. P., & Goodman, S. R.
(1991).
Identification of a mouse brain beta-spectrin cDNA and distribution of its mRNA in adult tissues. Brain Research Bulletin.
27(2), 187-193.
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Zimmer, D. B., Song, W., & Zimmer, W. E.
(1991).
Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues. Brain Research Bulletin.
27(2), 157-162.
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Karinch, A. M., Zimmer, W. E., & Goodman, S. R.
(1990).
The identification and sequence of the actin-binding domain of human red blood cell beta-spectrin. Journal of Biological Chemistry.
265(20), 11833-11840.
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Zimmer, W. E., Schloss, J. A., Silflow, C. D., Youngblom, J., & Watterson, D. M.
(1988).
Structural organization, DNA sequence, and expression of the calmodulin gene. Journal of Biological Chemistry.
263(36), 19370-19383.
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Roberts, D. M., Zimmer, W. E., & Watterson, D. M.
(1987).
The use of synthetic oligodeoxyribonucleotides in the examination of calmodulin gene and protein structure and function. METHODS IN ENZYMOLOGY.
139(C), 290-303.
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Chang, K. S., Zimmer, W. E., Bergsma, D. J., Dodgson, J. B., & Schwartz, R. J.
(1984).
Isolation and characterization of six different chicken actin genes. Molecular and Cellular Biology.
4(11), 2498-2508.
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Tsai, M. J., Ting, A. C., Nordstrom, J. L., Zimmer, W., & O'Malley, B. W.
(1980).
Processing of high molecular weight ovalbumin and ovomucoid precursor RNAs to messenger RNA. Cell.
22(1 Pt 1), 219-230.
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Hammerle, C. M., Sandovici, I., Brierley, G. V., Smith, N. M., Zimmer, W. E., Zvetkova, I., ... Constncia, M.
(2020).
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLOS Genetics.
16(10), e1009069-e1009069.
-
chapter
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Goodman, S. R., & Zimmer, W. E.
(2008).
Cytoskeleton. Medical Cell Biology.
(pp. 59-100).
Elsevier.
-
Zimmer, W. E.
(2008).
Regulation of Gene Expression. Medical Cell Biology.
(pp. 149-190).
Elsevier.
-
Balczon, R., Bao, L., Zimmer, W. E., Brown, K., Zinkowski, R. P., & Brinkley, B. R.
(1994).
Analysis of Centrosome Replication Events in Mammalian Cells. The Cell Cycle.
(pp. 229-235).
Springer Nature.
-
Goodman, S. R., & Zimmer, W. E.
(2008).
Cytoskeleton. Medical Cell Biology.
(pp. 59-100).
Elsevier.
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conference paper
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Zimmer, W. E.
(2006).
Spectrin's key role in synaptic transmission. The FASEB Journal.
A868-A868.
-
Zimmer, W. E., Stanfel, M. N., Moses, K. A., Chi, X., Takamoto, N., Dean, D. A., & Schwartz, R. J.
(2005).
The bagpipe homolog Nkx3.2 is an important factor in the specification of bone and intestinal tract mesoderm. Mechanisms of Development.
S64-S64.
-
Van Eldik, L. J., Zimmer, W. E., Barger, S. W., & Watterson, D. M.
(1990).
Perturbation of the calmodulin system in transformed cells. Advances in Experimental Medicine and Biology.
111-120.
-
Lukas, T. J., Haiech, J., Lau, W., Craig, T. A., Zimmer, W. E., Shattuck, R. L., Shoemaker, M. O., & Watterson, D. M.
(1988).
Calmodulin and calmodulin-regulated protein kinases as transducers of intracellular calcium signals. Cold Spring Harbor Laboratory: Symposia on Quantitative Biology.
185-193.
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ZIMMER, W. E., CHANG, K. S., BERGSMA, D., & SCHWARTZ, R.
(1983).
ORGANIZATION AND EXPRESSION OF THE CHICKEN ACTIN MULTIGENE FAMILY DURING MYOGENESIS. The Journal of Cell Biology.
A330-A330.
-
Zimmer, W. E.
(2006).
Spectrin's key role in synaptic transmission. The FASEB Journal.
A868-A868.
Teaching
teaching activities
- MEID608 Neuroscience Instructor
- MSCI601 Contem Top In Adv Cell Bio I Instructor
- MSCI685 Directed Studies Instructor
- MSCI689 Sptp:career Dev Phd Scientist Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Cell Biology, Baylor College of Medicine - (Houston, Texas, United States) 1985
- B.S. in Biology, University of Houston - (Houston, Texas, United States) 1977
- Vanderbilt University - (Nashville, Tennessee, United States) , Postdoctoral Training 1989
awards and honors
Contact
first name
- Warren
has last name
- Zimmer
mailing address
-
Texas A&M Health Science Center
Medical Physiology
1114 TAMUS
College Station, TX 77843-1114
USA
Other
- wezimmer@tamu.edu