HR job title
- Assistant Professor
- Contact Info
Walsh, Alex Assistant Professor
Positions
- Assistant Professor, Biomedical Engineering, College of Engineering
Research Areas
- Overview
- Publications
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Yu, W., Chen, Y., Putluri, N., Osman, A., Coarfa, C., Putluri, V., ... Sandulache, V. C.
(2023).
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. British Journal of Cancer.
128(11), 2013-2024.
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Hu, L., Morganti, S., Nguyen, U., Benavides, O. R., & Walsh, A. J.
(2023).
Label-free optical imaging of cell function and collagen structure for cell-based therapies. Current Opinion in Biomedical Engineering.
25, 100433-100433.
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Liu, L., Zhou, Y. i., Liu, Z., Li, J., Hu, L., He, L., ... Xie, L.
(2023).
Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression. Cellular and Molecular Gastroenterology and Hepatology.
15(5), 1117-1133.
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Benavides, O. R., Gibbs, H. C., White, B. P., Kaunas, R., Gregory, C. A., Walsh, A. J., & Maitland, K. C.
(2023).
Volumetric imaging of human mesenchymal stem cells (hMSCs) for non-destructive quantification of 3D cell culture growth. PLoS One.
18(3), e0282298-e0282298.
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VandenHeuvel, S. N., Farris, H. A., Noltensmeyer, D. A., Roy, S., Donehoo, D. A., Kopetz, S., ... Raghavan, S.
(2022).
Decellularized organ biomatrices facilitate quantifiable in vitro 3D cancer metastasis models. SOFT MATTER.
18(31), 5791-5806.
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Cardona, E. N., & Walsh, A. J.
(2022).
Identification of rare cell populations in autofluorescence lifetime image data. Cytometry Part A.
101(6), 497-506.
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Miskolci, V., Tweed, K. E., Lasarev, M. R., Britt, E. C., Walsh, A. J., Zimmerman, L. J., ... Huttenlocher, A.
(2022).
In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish. eLife.
11, e66080.
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Theodossiou, A., Hu, L., Wang, N., Nguyen, U., & Walsh, A. J.
(2021).
Autofluorescence Imaging to Evaluate Cellular Metabolism. Journal of Visualized Experiments.
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Schmitz, R., Tweed, K., Walsh, C., Walsh, A. J., & Skala, M. C.
(2021).
Extracellular pH affects the fluorescence lifetimes of metabolic co-factors. 26(5), 056502-056502.
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Walsh, A. J., Mueller, K. P., Tweed, K., Jones, I., Walsh, C. M., Piscopo, N. J., ... Skala, M. C.
(2021).
Classification of T-cell activation via autofluorescence lifetime imaging. Nature Biomedical Engineering.
5(1), 77-88.
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Hu, L., Wang, N., Cardona, E., & Walsh, A. J.
(2020).
Fluorescence intensity and lifetime redox ratios detect metabolic perturbations in T cells. Biomedical Optics Express.
11(10), 5674-5688.
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Wang, Z. J., Walsh, A. J., Skala, M. C., & Gitter, A.
(2020).
Classifying T cell activity in autofluorescence intensity images with convolutional neural networks. Journal of Biophotonics.
13(3), e201960050.
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Heaster, T. M., Walsh, A. J., Zhao, Y., Hiebert, S. W., & Skala, M. C.
(2018).
Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level. Journal of Biophotonics.
11(1),
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Zhang, Q., Jeppesen, D. K., Higginbotham, J. N., Demory Beckler, M., Poulin, E. J., Walsh, A. J., ... Coffey, R. J.
(2018).
Mutant KRAS Exosomes Alter the Metabolic StateofRecipient ColonicEpithelial Cells. Cellular and Molecular Gastroenterology and Hepatology.
5(4), 627-629.e6.
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Walsh, A. J., Cook, R. S., & Skala, M. C.
(2017).
Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen. JOURNAL OF NUCLEAR MEDICINE.
58(9), 1367-1372.
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Walsh, A. J., Tolstykh, G. P., Martens, S., Ibey, B. L., & Beier, H. T.
(2016).
Action potential block in neurons by infrared light. Neurophotonics.
3(4), 040501-040501.
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Walsh, A. J., Castellanos, J. A., Nagathihalli, N. S., Merchant, N. B., & Skala, M. C.
(2016).
Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response. Pancreas.
45(6), 863-869.
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Walsh, A. J., Sharick, J. T., Skala, M. C., & Beier, H. T.
(2016).
Temporal binning of time-correlated single photon counting data improves exponential decay fits and imaging speed. Biomedical Optics Express.
7(4), 1385-1399.
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Walsh, A. J., Cook, R. S., Sanders, M. E., Arteaga, C. L., & Skala, M. C.
(2016).
Drug response in organoids generated from frozen primary tumor tissues. Scientific Reports.
6(1), 18889.
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Nagathihalli, N. S., Castellanos, J. A., Shi, C., Beesetty, Y., Reyzer, M. L., Caprioli, R., ... Merchant, N. B.
(2015).
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. GASTROENTEROLOGY.
149(7), 1932-1943.e9.
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Shah, A. T., Diggins, K. E., Walsh, A. J., Irish, J. M., & Skala, M. C.
(2015).
In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment. Neoplasia.
17(12), 862-870.
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Campos-Delgado, D. U., Navarro, O. G., Arce-Santana, E. R., Walsh, A. J., Skala, M. C., & Jo, J. A.
(2015).
Deconvolution of fluorescence lifetime imaging microscopy by a library of exponentials. Optics Express.
23(18), 23748-23767.
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Campos-Delgado, D. U., Gutierrez-Navarro, O., Arce-Santana, E. R., Skala, M. C., Walsh, A. J., & Jo, J. A.
(2015).
Blind deconvolution estimation of fluorescence measurements through quadratic programming. Journal of Biomedical Optics.
20(7), 075010-075010.
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Walsh, A. J., Cook, R. S., Lee, J. H., Arteaga, C. L., & Skala, M. C.
(2015).
Collagen density and alignment in responsive and resistant trastuzumab-treated breast cancer xenografts. Journal of Biomedical Optics.
20(2), 26004-026004.
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Walsh, A. J., & Skala, M. C.
(2015).
Optical metabolic imaging quantifies heterogeneous cell populations. Biomedical Optics Express.
6(2), 559-573.
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Cannon, T. M., Shah, A. T., Walsh, A. J., & Skala, M. C.
(2015).
High-throughput measurements of the optical redox ratio using a commercial microplate reader. Journal of Biomedical Optics.
20(1), 010503-010503.
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Walsh, A. J., Cook, R. S., Sanders, M. E., Aurisicchio, L., Ciliberto, G., Arteaga, C. L., & Skala, M. C.
(2014).
Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer. 74(18), 5184-5194.
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McCormack, D. R., Walsh, A. J., Sit, W., Arteaga, C. L., Chen, J., Cook, R. S., & Skala, M. C.
(2014).
In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts. Biomedical Optics Express.
5(7), 2247-2261.
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Shah, A. T., Demory Beckler, M., Walsh, A. J., Jones, W. P., Pohlmann, P. R., & Skala, M. C.
(2014).
Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma. 9(3), e90746-e90746.
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Venkateswaran, A., Sekhar, K. R., Levic, D. S., Melville, D. B., Clark, T. A., Rybski, W. M., ... Freeman, M. L.
(2014).
The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Research.
74(1), 38-43.
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Walsh, A. J., Cook, R. S., Manning, H. C., Hicks, D. J., Lafontant, A., Arteaga, C. L., & Skala, M. C.
(2013).
Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer. 73(20), 6164-6174.
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Poole, K. M., Tucker-Schwartz, J. M., Sit, W. W., Walsh, A. J., Duvall, C. L., & Skala, M. C.
(2013).
Quantitative optical imaging of vascular response in vivo in a model of peripheral arterial disease. American Journal of Physiology: Heart and Circulatory Physiology.
305(8), H1168-H1180.
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Venkateswaran, A., Friedman, D. B., Walsh, A. J., Skala, M. C., Sasi, S., Rachakonda, G., ... Sekhar, K. R.
(2013).
The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Investigational New Drugs.
31(3), 535-544.
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Walsh, A. J., Masters, D. B., Jansen, E. D., Welch, A. J., & Mahadevan-Jansen, A.
(2012).
The effect of temperature on the autofluorescence of scattering and non-scattering tissue. LASERS IN SURGERY AND MEDICINE.
44(9), 712-718.
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Walsh, A. J., Poole, K. M., Duvall, C. L., & Skala, M. C.
(2012).
Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status. Journal of Biomedical Optics.
17(11), 116015-116015.
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Walsh, A., Cook, R. S., Rexer, B., Arteaga, C. L., & Skala, M. C.
(2012).
Optical imaging of metabolism in HER2 overexpressing breast cancer cells. Biomedical Optics Express.
3(1), 75-85.
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Bi, X., Walsh, A., Mahadevan-Jansen, A., & Herline, A.
(2011).
Development of spectral markers for the discrimination of ulcerative colitis and Crohn's disease using Raman spectroscopy. Diseases of the Colon and Rectum.
54(1), 48-53.
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Zaman, R. T., Rajaram, N., Walsh, A., Oliver, J., Rylander, H. G., Tunnell, J. W., Welch, A. J., & Mahadevan-Jansen, A.
(2011).
Variation of fluorescence in tissue with temperature. LASERS IN SURGERY AND MEDICINE.
43(1), 36-42.
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Yu, W., Chen, Y., Putluri, N., Osman, A., Coarfa, C., Putluri, V., ... Sandulache, V. C.
(2023).
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. British Journal of Cancer.
128(11), 2013-2024.
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chapter
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Walsh, A. J., Shah, A. T., Sharick, J. T., & Skala, M. C.
(2015).
Fluorescence Lifetime Measurements of NAD(P)H in Live Cells and Tissue. Springer Series in Chemical Physics.
Becker, W. (Eds.),
Advanced Time-Correlated Single Photon Counting Applications.
(pp. 435-456).
Springer Nature.
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Walsh, A. J., Shah, A. T., Sharick, J. T., & Skala, M. C.
(2015).
Fluorescence Lifetime Measurements of NAD(P)H in Live Cells and Tissue. Springer Series in Chemical Physics.
Becker, W. (Eds.),
Advanced Time-Correlated Single Photon Counting Applications.
(pp. 435-456).
Springer Nature.
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conference paper
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Hu, L., & Walsh, A. J.
(2022).
Modeling key metabolic pathways of cancer cells using label-free fluorescence lifetime imaging. Proceedings of SPIE.
1197206-1197206-7.
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Sharma, D., Hu, L., Chen, T., Sharma, A., He, W., Goldman, J., Walsh, A. J., & Zhao, F.
(2022).
Perfusable Human Mesenchymal Stem Cell Patch Ameliorates Innate Immune Response. Tissue Engineering Part A.
208-209.
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Walsh, A. J., Sedelnikova, A., Tolstykh, G. P., Ibey, B. L., & Beier, H. T.
(2017).
Fluorescence Lifetime Imaging of Calcium Flux in Neurons in Response to Pulsed Infrared Light. Proceedings of SPIE.
100691b-100691b-8.
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Walsh, A. J., Tolstykh, G. P., Martens, S. L., Ibey, B. L., & Beier, H. T.
(2017).
Short Infrared Laser Pulses Block Action Potentials in Neurons. Proceedings of SPIE.
100520j-100520j-7.
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Walsh, A. J., Cantu, J. C., Ibey, B. L., & Beier, H. T.
(2017).
Short Infrared Laser Pulses Increase Cell Membrane Fluidity. Proceedings of SPIE.
100620d-100620d-6.
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Walsh, A. J., Tolstykh, G., Martens, S., Sedelnikova, A., Ibey, B. L., & Beier, H. T.
(2016).
All Optical Experimental Design for Neuron Excitation, Inhibition, and Action Potential Detection. Proceedings of SPIE.
96901p-96901p-6.
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Walsh, A. J., & Beier, H. T.
(2016).
Temporal and spatial binning of TCSPC data to improve signal-to-noise ratio and imaging speed. Proceedings of SPIE.
97120r-97120r-7.
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Walsh, A. J., & Skala, M. C.
(2014).
An automated image processing routine for segmentation of cell cytoplasms in high-resolution autofluorescence images. Proceedings of SPIE.
89481m-89481m-6.
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Walsh, A. J., Cook, R. S., Arteaga, C. L., & Skala, M. C.
(2013).
Optical metabolic imaging of live tissue cultures. Proceedings of SPIE.
858820-858820-6.
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Walsh, A., Masters, B., Jansen, D., Welch, A. J., & Mahadevan-Jansen, A.
(2010).
The effect of temperature of fluorescence: an animal study. Proceedings of SPIE.
75620w-75620w-5.
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Hu, L., & Walsh, A. J.
(2022).
Modeling key metabolic pathways of cancer cells using label-free fluorescence lifetime imaging. Proceedings of SPIE.
1197206-1197206-7.
Teaching
teaching activities
- BMEN291 Hnr-research Instructor
- BMEN322 Biosignal Analysis Instructor
- BMEN422 Bioelectromagnetism Instructor
- BMEN491 Hnr-research Instructor
- BMEN608 Biophotonics Ii Instructor
- BMEN622 Bioelectromagnetism Instructor
- BMEN691 Research Instructor
Background
education and training
- Ph.D. in Biomedical Engineering, Vanderbilt University - (Nashville, Tennessee, United States) 2015
- M.S. in Biomedical Engineering, Vanderbilt University - (Nashville, Tennessee, United States) 2012
- B.E. in Biomedical Engineering, Vanderbilt University - (Nashville, Tennessee, United States) 2010
awards and honors
Contact
first name
- Alex
has last name
- Walsh
Other
- walshaj@tamu.edu