HR job title
- Research Associate Professor
- Contact Info
- 1 979 436 9427
Choi, K. Yeon Associate Professor
Positions
- Research Associate Professor, School of Medicine, Health Science Center
My research includes studying the cellular immune response of target leukocytes to cytomegalovirus infection in the fetal-placental unit and also the mechanism of CMV deafness of the developing fetus in utero. I also have a long term interest in the relationship of cancer to viral infections and will investigate the potential link of CMV and other herpesviruses to specific types of cancer.
- Overview
- Publications
- Research
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Overview
Publications
selected publications
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academic article
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2022).
Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model. Viruses.
14(4), 760-760.
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Choi, K. Y., El-Hamdi, N., & McGregor, A.
(2022).
Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein. Journal of Virology.
96(17), e0083122-e00822.
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Choi, K. Y., & McGregor, A.
(2021).
A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary. Viruses.
13(8), 1467-1467.
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Choi, K. Y., El-Hamdi, N., Hornig, J., & McGregor, A.
(2021).
Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism. Journal of Virology.
95(10), JVI.00324-JVI.00321.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2021).
A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs. JOURNAL OF GENERAL VIROLOGY.
102(3),
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2020).
Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease. International Journal of Molecular Sciences.
21(17), 5997-5997.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2020).
Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells. JOURNAL OF GENERAL VIROLOGY.
101(4), 426-439.
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El-Hamdi, N. S., Choi, K. Y., & McGregor, A.
(2020).
Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry. Virology.
548, 236-249.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2020).
Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model. Vaccine.
38(10), 2340-2349.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2019).
Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model. Journal of Virology.
93(22), e01442-e01419.
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Hornig, J., Choi, K. Y., & McGregor, A.
(2017).
The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting. Virology.
504, 122-140.
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Coleman, S., Choi, K. Y., & McGregor, A.
(2017).
Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig. Virology.
509, 205-221.
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Choi, K. Y., Root, M., & McGregor, A.
(2016).
A Novel Non-Replication-Competent Cytomegalovirus Capsid Mutant Vaccine Strategy Is Effective in Reducing Congenital Infection. Journal of Virology.
90(17), 7902-7919.
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Coleman, S., Choi, K. Y., Root, M., & McGregor, A.
(2016).
A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus. PLOS Pathogens.
12(7), e1005755-e1005755.
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Coleman, S., Hornig, J., Maddux, S., Choi, K. Y., & McGregor, A.
(2015).
Correction: Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus. PLoS ONE.
10(9), e0137942-e0137942.
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Coleman, S., Hornig, J., Maddux, S., Choi, K. Y., & McGregor, A.
(2015).
Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus. PLoS ONE.
10(8), e0135567-e0135567.
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Schleiss, M. R., Choi, K. Y., Anderson, J., Mash, J. G., Wettendorff, M., Mossman, S., & Van Damme, M.
(2014).
Glycoprotein B (gB) vaccines adjuvanted with AS01 or AS02 protect female guinea pigs against cytomegalovirus (CMV) viremia and offspring mortality in a CMV-challenge model. Vaccine.
32(23), 2756-2762.
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Buehring, G. C., Shen, H. M., Jensen, H. M., Choi, K. Y., Sun, D., & Nuovo, G.
(2014).
Bovine leukemia virus DNA in human breast tissue. Emerging Infectious Diseases.
20(5), 772-782.
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Schleiss, M. R., Buus, R., Choi, K. Y., & McGregor, A.
(2013).
An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model. Future Virology.
8(12), 1151-1160.
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Leviton, M. P., Lacayo, J. C., Choi, K. Y., Hernandez-Alvarado, N., Wey, A., & Schleiss, M. R.
(2013).
An attenuated cytomegalovirus vaccine with a deletion of a viral chemokine gene is protective against congenital CMV transmission in a guinea pig model. Clinical and Developmental Immunology.
2013, 906948-12.
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Choi, K. Y., Sharon, B., Balfour, H. H., Belani, K., Pozos, T. C., & Schleiss, M. R.
(2013).
Emergence of antiviral resistance during oral valganciclovir treatment of an infant with congenital cytomegalovirus (CMV) infection. Journal of Clinical Virology.
57(4), 356-360.
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McGregor, A., & Choi, K. Y.
(2011).
Cytomegalovirus antivirals and development of improved animal models. Expert Opinion on Drug Metabolism and Toxicology.
7(10), 1245-1265.
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Olejniczak, M. J., Choi, K. Y., McVoy, M. A., Cui, X., & Schleiss, M. R.
(2011).
Intravaginal cytomegalovirus (CMV) challenge elicits maternal viremia and results in congenital transmission in a guinea pig model. 8(1), 89.
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McGregor, A., Choi, K. Y., & Schleiss, M. R.
(2011).
Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV. Virology.
410(1), 76-87.
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Choi, K. Y., Schleiss, M., & Huang, T.
(2010).
Vaccine Therapy for Cytomegalovirus Induced Hearing Loss. 143(S2), p252-p253.
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Choi, K. Y., Schimmenti, L. A., Jurek, A. M., Sharon, B., Daly, K., Khan, C., McCann, M., & Schleiss, M. R.
(2009).
Detection of cytomegalovirus DNA in dried blood spots of Minnesota infants who do not pass newborn hearing screening. The Pediatric Infectious Disease Journal.
28(12), 1095-1098.
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Crumpler, M. M., Choi, K. Y., McVoy, M. A., & Schleiss, M. R.
(2009).
A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection. Vaccine.
27(31), 4209-4218.
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Wang, M., Holmes-Davis, R., Rafinski, Z., Jedrzejewska, B., Choi, K. Y., Zwick, M., ... Koshinsky, H.
(2009).
Accelerated photobleaching of a cyanine dye in the presence of a ternary target DNA, PNA probe, dye catalytic complex: a molecular diagnostic. Analytical Chemistry.
81(6), 2043-2052.
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Schleiss, M. R., McGregor, A., Choi, K. Y., Date, S. V., Cui, X., & McVoy, M. A.
(2008).
Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome. Virology Journal.
5(1), 139-139.
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Schleiss, M., Eickhoff, J., Auerochs, S., Leis, M., Abele, S., Rechter, S., ... Marschall, M.
(2008).
Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo. ANTIVIRAL RESEARCH.
79(1), 49-61.
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McGregor, A., Choi, K. Y., Cui, X., McVoy, M. A., & Schleiss, M. R.
(2008).
Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir. ANTIVIRAL RESEARCH.
78(3), 250-259.
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Hans, D. M., Sharon, B., Choi, K. Y., Bendel, C. M., & Schleiss, M. R.
(2008).
Severe clinical deterioration in a preterm twin following discordant transmission of cytomegalovirus via breast milk. Journal of neonatal-perinatal medicine.
1(3), 189-192.
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Schraff, S. A., Schleiss, M. R., Brown, D. K., Meinzen-Derr, J., Choi, K. Y., Greinwald, J. H., & Choo, D. I.
(2007).
Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury. Otolaryngology.
137(4), 612-618.
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Buehring, G. C., Philpott, S. M., & Choi, K. Y.
(2003).
Humans have antibodies reactive with Bovine leukemia virus. AIDS RESEARCH AND HUMAN RETROVIRUSES.
19(12), 1105-1113.
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Choi, K. Y., Monke, D., & Stott, J. L.
(2002).
Absence of bovine leukosis virus in semen of seropositive bulls. Journal of Veterinary Diagnostic Investigation.
14(5), 403-406.
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Choi, K. Y., Liu, R. B., & Buehring, G. C.
(2002).
Relative sensitivity and specificity of agar gel immunodiffusion, enzyme immunosorbent assay, and immunoblotting for detection of anti-bovine leukemia virus antibodies in cattle. Journal of Virological Methods.
104(1), 33-39.
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Buehring, G. C., Choi, K. Y., & Jensen, H. M.
(2001).
Bovine leukemia virus in human breast tissues. Breast Cancer Research.
3(Suppl 1), a14.
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Choi, Y., Chuang, L. F., Lam, K. M., Kung, H. F., Wang, J. M., Osburn, B. I., & Chuang, R. Y.
(1998).
Inhibition of chemokine-induced chemotaxis of monkey leukocytes by mu-opioid receptor agonists. In Vivo: international journal of experimental and clinical pathophysiology and drug research.
13(5), 389-396.
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Keefe, R. G., Choi, Y., Ferrick, D. A., & Stott, J. L.
(1997).
Bovine cytokine expression during different phases of bovine leukemia virus infection. Veterinary Immunology and Immunopathology.
56(1-2), 39-51.
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Taylor, B. C., Choi, K. Y., Scibienski, R. J., Moore, P. F., & Stott, J. L.
(1993).
Differential expression of bovine MHC class II antigens identified by monoclonal antibodies. 53(5), 479-489.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2022).
Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model. Viruses.
14(4), 760-760.
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chapter
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McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J.
(2013).
Chapter 37 Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease.
(pp. 905-925).
Elsevier.
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McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J.
(2013).
Human Herpesviruses and Animal Models. ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE.
(pp. 905-925).
Elsevier.
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McGregor, A., Yeon Choi, K., & Sung, H.
(2012).
Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions. Cytomegalovirus Infections: Risk Factors, Causes and Management.
(pp. 77-118).
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McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J.
(2013).
Chapter 37 Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease.
(pp. 905-925).
Elsevier.
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conference paper
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McGregor, A., Choi, K. Y., Schleiss, M., Kronneman, D., & Root, M.
(2012).
A novel replication impaired virus vaccine strategy is effective against congenital cytomegalovirus infection. Immunology.
754-754.
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McGregor, A., Choi, K. Y., Schleiss, M., Bouska, C., Leviton, M., & Sweet, J.
(2012).
Analysis of the essential nature of viral proteins considered to be important target antigens against CMV in candidate vaccine strategies in the guinea pig model. Immunology.
634-635.
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Schleiss, M. R., Choi, K. Y., McGregor, A., Leviton, M., & Buus, R.
(2010).
A LIVE, ATTENUATED CMV VACCINE PROTECTS AT THE PLACENTAL-FETAL INTERFACE IN THE GUINEA PIG MODEL OF CONGENITAL CMV INFECTION. Placenta.
A112-A112.
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McGregor, A., Choi, K. Y., Schleiss, M., Kronneman, D., & Root, M.
(2012).
A novel replication impaired virus vaccine strategy is effective against congenital cytomegalovirus infection. Immunology.
754-754.
Research
co-principal investigator on
- Development of an Effective DISC Vaccine Strategy Against Congenital CMV awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
- Placental Trophoblast Infection and TLR Mediated Response to Congenital CMV awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
investigator on
Background
education and training
- Ph.D. in Immunology, University of California, Davis - (Davis, California, United States) 1997
- B.S. in Microbiology, Texas A&M University - (College Station, Texas, United States) 1989
- University of California, Berkeley - (Berkeley, California, United States) , Postdoctoral Training 2000
Contact
first name
- K. Yeon
has last name
- Choi
mailing address
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Texas A&M Health Science Center
8447 Riverside Parkway
MREB2 3209, MPIM
Bryan, TX 77807
USA
Other
- yeonchoi@tamu.edu