HR job title
- Professor
- Contact Info
- 1 979 845 2344
Muneoka, Ken Professor
Positions
My lab is focused on understanding epimorphic and tissue regeneration in mammals.
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- Teaching
- Background
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Overview
Publications
selected publications
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academic article
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Lin, Y., Yu, L., Yan, M., Zimmel, K., Qureshi, O., Imholt, F., ... Muneoka, K.
(2023).
Induced regeneration of articular cartilage: Identification of a dormant regeneration program for a non-regenerative tissue. dev.201894.
-
Yu, L., Lin, Y., Yan, M., Li, T., Wu, E. Y., Zimmel, K., ... Muneoka, K.
(2022).
Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine. Development (Cambridge).
149(2), dev200249.
-
Muneoka, K., & Dawson, L. A.
(2021).
Evolution of epimorphosis in mammals. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
336(2), 165-179.
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Dawson, L. A., Brunauer, R., Zimmel, K. N., Qureshi, O., Falck, A. R., Kim, P., ... Muneoka, K.
(2019).
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification. Journal of Visualized Experiments.
2019(149),
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Dolan, C. P., Yan, M., Zimmel, K., Yang, T., Leininger, E., Dawson, L. A., & Muneoka, K.
(2019).
Axonal regrowth is impaired during digit tip regeneration in mice. Developmental Biology.
445(2), 237-244.
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Yu, L., Dawson, L. A., Yan, M., Zimmel, K., Lin, Y., Dolan, C. P., Han, M., & Muneoka, K.
(2019).
BMP9 stimulates joint regeneration at digit amputation wounds in mice. Nature Communications.
10(1), 424.
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Busse, E., Simkin, J., Marrero, L., Stewart, K., Brunauer, R., Muneoka, K., ... Sammarco, M.
(2019).
Sirtuin 3 deficiency does not impede digit regeneration in mice. Scientific Reports.
9(1), 16491.
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Dawson, L. A., Schanes, P. P., Kim, P., Imholt, F. M., Qureshi, O., Dolan, C. P., ... Muneoka, K.
(2018).
Blastema formation and periosteal ossification in the regenerating adult mouse digit. WOUND REPAIR AND REGENERATION.
26(3), 263-273.
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Dolan, C. P., Dawson, L. A., & Muneoka, K.
(2018).
Digit Tip Regeneration: Merging Regeneration Biology with Regenerative Medicine. Stem Cells Translational Medicine.
7(3), 262-270.
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Brunauer, R., & Muneoka, K.
(2018).
The Impact of Aging on Mechanisms of Mammalian Epimorphic Regeneration. Gerontology: international journal of experimental, clinical, behavioral, regenerative and technical gerontology.
64(3), 300-308.
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Seifert, A. W., & Muneoka, K.
(2018).
The blastema and epimorphic regeneration in mammals. Developmental Biology.
433(2), 190-199.
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Simkin, J., Sammarco, M. C., Marrero, L., Dawson, L. A., Yan, M., Tucker, C., Cammack, A., & Muneoka, K.
(2017).
Macrophages are required to coordinate mouse digit tip regeneration. Development (Cambridge).
144(21), 3907-3916.
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Dawson, L. A., Yu, L., Yan, M., Marrero, L., Schanes, P. P., Dolan, C., ... Muneoka, K.
(2017).
The periosteal requirement and temporal dynamics of BMP2-induced middle phalanx regeneration in the adult mouse. Regeneration.
4(3), 140-150.
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Marrero, L., Simkin, J., Sammarco, M., & Muneoka, K.
(2017).
Fibroblast reticular cells engineer a blastema extracellular network during digit tip regeneration in mice. Regeneration.
4(2), 69-84.
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Dawson, L. A., Simkin, J., Sauque, M., Pela, M., Palkowski, T., & Muneoka, K.
(2016).
Analogous cellular contribution and healing mechanisms following digit amputation and phalangeal fracture in mice. Regeneration.
3(1), 39-51.
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Phan, A. Q., Lee, J., Oei, M., Flath, C., Hwe, C., Mariano, R., ... Gardiner, D. M.
(2015).
Positional information in axolotl and mouse limb extracellular matrix is mediated via heparan sulfate and fibroblast growth factor during limb regeneration in the axolotl (Ambystoma mexicanum). Regeneration.
2(4), 182-201.
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Simkin, J., Sammarco, M. C., Dawson, L. A., Tucker, C., Taylor, L. J., Van Meter, K., & Muneoka, K.
(2015).
Epidermal closure regulates histolysis during mammalian (Mus) digit regeneration. Regeneration.
2(3), 106-119.
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Voss, S. R., Palumbo, A., Nagarajan, R., Gardiner, D. M., Muneoka, K., Stromberg, A. J., & Athippozhy, A. T.
(2015).
Gene expression during the first 28 days of axolotl limb regeneration I: Experimental design and global analysis of gene expression. Regeneration.
2(3), 120-136.
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Simkin, J., Sammarco, M. C., Dawson, L. A., Schanes, P. P., Yu, L., & Muneoka, K.
(2015).
The mammalian blastema: regeneration at our fingertips. Regeneration.
2(3), 93-105.
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Sammarco, M. C., Simkin, J., Fassler, D., Cammack, A. J., Wilson, A., Van Meter, K., & Muneoka, K.
(2015).
Endogenous Bone Regeneration Is Dependent Upon a Dynamic Oxygen Event. 30(2), 393-393.
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Sammarco, M. C., Simkin, J., Fassler, D., Cammack, A. J., Wilson, A., Van Meter, K., & Muneoka, K.
(2014).
Endogenous bone regeneration is dependent upon a dynamic oxygen event. Journal of Bone and Mineral Research.
29(11), 2336-2345.
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Yu, L., Yan, M., Simkin, J., Ketcham, P. D., Leininger, E., Han, M., & Muneoka, K.
(2014).
Angiogenesis is inhibitory for mammalian digit regeneration. Regeneration.
1(3), 33-46.
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Lee, J., Corcoran, A., Han, M., Gardiner, D. M., & Muneoka, K.
(2013).
Dlx5 and Msx2 regulate mouse anterior neural tube closure through ephrinA5-EphA7. Development, Growth and Differentiation.
55(3), 341-349.
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Wu, Y., Wang, K., Karapetyan, A., Fernando, W. A., Simkin, J., Han, M., Rugg, E. L., & Muneoka, K.
(2013).
Connective tissue fibroblast properties are position-dependent during mouse digit tip regeneration. PLoS ONE.
8(1), e54764-e54764.
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Lee, J., Marrero, L., Yu, L., Dawson, L. A., Muneoka, K., & Han, M.
(2013).
SDF-1/CXCR4 signaling mediates digit tip regeneration promoted by BMP-2. Developmental Biology.
382(1), 98-109.
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Simkin, J., Han, M., Yu, L., Yan, M., & Muneoka, K.
(2013).
The mouse digit tip: From wound healing to regeneration. Methods in molecular biology (Clifton, N.J.).
1037, 419-435.
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Simkin, J., Han, M., Yu, L., Yan, M., & Muneoka, K.
(2013).
The mouse digit tip: from wound healing to regeneration. Methods in molecular biology (Clifton, N.J.).
1037, 419-435.
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Yu, L., Han, M., Yan, M., Lee, J., & Muneoka, K.
(2012).
BMP2 induces segment-specific skeletal regeneration from digit and limb amputations by establishing a new endochondral ossification center. Developmental Biology.
372(2), 263-273.
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zpolat, B. D., Zapata, M., Daniel Frug, J., Coote, J., Lee, J., Muneoka, K., & Anderson, R.
(2012).
Regeneration of the elbow joint in the developing chick embryo recapitulates development. Developmental Biology.
372(2), 229-238.
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Liu, J., Johnson, K., Li, J., Piamonte, V., Steffy, B. M., Hsieh, M. H., ... Schultz, P. G.
(2011).
Regenerative phenotype in mice with a point mutation in transforming growth factor beta type I receptor (TGFBR1). Proceedings of the National Academy of Sciences of the United States of America.
108(35), 14560-14565.
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Fernando, W. A., Leininger, E., Simkin, J., Li, N. i., Malcom, C. A., Sathyamoorthi, S., Han, M., & Muneoka, K.
(2011).
Wound healing and blastema formation in regenerating digit tips of adult mice. Developmental Biology.
350(2), 301-310.
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Yu, L., Han, M., Yan, M., Lee, E., Lee, J., & Muneoka, K.
(2010).
BMP signaling induces digit regeneration in neonatal mice. Development (Cambridge).
137(4), 551-559.
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Ng-Muller, V., & Muneoka, K.
(2010).
In utero and exo utero surgery on rodent embryos. 476(C), 205-226.
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Muneoka, K., Allan, C. H., Yang, X., Lee, J., & Han, M.
(2008).
Mammalian regeneration and regenerative medicine. Birth Defects Research Part C: Embryo Today Reviews.
84(4), 265-280.
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Song, Y., Yan, M., Muneoka, K., & Chen, Y.
(2008).
Mouse embryonic diastema region is an ideal site for the development of ectopically transplanted tooth germ. Developmental Dynamics.
237(2), 411-416.
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Han, M., Yang, X., Lee, J., Allan, C. H., & Muneoka, K.
(2008).
Development and regeneration of the neonatal digit tip in mice. Developmental Biology.
315(1), 125-135.
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Muneoka, K., Han, M., & Gardiner, D. M.
(2008).
Regrowing human limbs. Scientific American.
298(4), 56-63.
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Yu, L., Liu, H., Yan, M., Yang, J., Long, F., Muneoka, K., & Chen, Y.
(2007).
Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Developmental Biology.
306(2), 549-559.
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Han, M., Yang, X., Taylor, G., Burdsal, C. A., Anderson, R. A., & Muneoka, K.
(2005).
Limb regeneration in higher vertebrates: developing a roadmap. 287(1), 14-24.
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Han, M., Yang, X., Farrington, J. E., & Muneoka, K.
(2003).
Digit regeneration is regulated by Msx1 and BMP4 in fetal mice. Development (Cambridge).
130(21), 5123-5132.
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Omi, M., Anderson, R., & Muneoka, K.
(2002).
Differential cell affinity and sorting of anterior and posterior cells during outgrowth of recombinant avian limb buds. Developmental Biology.
250(2), 292-304.
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Han, M., & Muneoka, K.
(2001).
The role of Msx1 and Bmp4 in digit tip regeneration of mice. Developmental Biology.
235(1), 199-200.
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Schaller, S. A., & Muneoka, K.
(2001).
Inhibition of polarizing activity in the anterior limb bud is regulated by extracellular factors. Developmental Biology.
240(2), 443-456.
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Schaller, S. A., Li, S., Ngo-Muller, V., Han, M. J., Omi, M., Anderson, R., & Muneoka, K.
(2001).
Cell biology of limb patterning. International review of cytology.
203, 483-517.
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Ngo-Muller, V., & Muneoka, K.
(2000).
Exo utero surgery. Methods in molecular biology (Clifton, N.J.).
135, 481-492.
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Ngo-Muller, V., & Muneoka, K.
(2000).
Influence of FGF4 on digit morphogenesis during limb development in the mouse. Developmental Biology.
219(2), 224-236.
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Li, S., & Muneoka, K.
(1999).
Cell migration and chick limb development: chemotactic action of FGF-4 and the AER. Developmental Biology.
211(2), 335-347.
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Muller, T. L., Ngo-Muller, V., Reginelli, A., Taylor, G., Anderson, R., & Muneoka, K.
(1999).
Regeneration in higher vertebrates: limb buds and digit tips. Seminars in Cell and Developmental Biology.
10(4), 405-413.
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Muneoka, K.
(1998).
Researching the limb: 50 years later. Journal of Experimental Zoology.
282(6), 627.
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Li, S., Anderson, R., Reginelli, A. D., & Muneoka, K.
(1996).
FGF-2 influences cell movements and gene expression during limb development. 274(4), 234-247.
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Reginelli, A. D., Wang, Y. Q., Sassoon, D., & Muneoka, K.
(1995).
Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development (Cambridge).
121(4), 1065-1076.
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Anderson, R., Landry, M., Reginelli, A., Taylor, G., Achkar, C., Gudas, L., & Muneoka, K.
(1994).
Conversion of anterior limb bud cells to ZPA signaling cells in vitro and in vivo. Developmental Biology.
164(1), 241-257.
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Taylor, G. P., Anderson, R., Reginelli, A. D., & Muneoka, K.
(1994).
FGF-2 induces regeneration of the chick limb bud. Developmental Biology.
163(1), 282-284.
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Hayamizu, T. F., Wanek, N., Taylor, G., Trevino, C., Shi, C., Anderson, R., ... Bryant, S. V.
(1994).
Regeneration of HoxD expression domains during pattern regulation in chick wing buds. Developmental Biology.
161(2), 504-512.
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Anderson, R., Landry, M., & Muneoka, K.
(1993).
Maintenance of ZPA signaling in cultured mouse limb bud cells. Development (Cambridge).
117(4), 1421-1433.
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Trevino, C., Anderson, R., & Muneoka, K.
(1993).
3T3 cell integration and differentiative potential during limb development in the mouse. Developmental Biology.
155(1), 38-45.
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Anderson, R., Landry, M., & Muneoka, K.
(1993).
In vitro maintenance of posterior (ZPA) signaling in mouse limb bud cells. Progress in clinical and biological research.
383A, 371-380.
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Trevio, C., Anderson, R., Landry, M., Knig, G., Tonthat, B., Shi, C., & Muneoka, K.
(1993).
MPLB-2: a posterior signaling cell line derived from the mouse limb bud. Progress in clinical and biological research.
383A, 295-304.
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Muneoka, K., & Sassoon, D.
(1992).
Molecular aspects of regeneration in developing vertebrate limbs. Developmental Biology.
152(1), 37-49.
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Trevino, C., Calof, A., & Muneoka, K.
(1992).
Position specific growth regulation of 3T3 cells in vivo. Developmental Biology.
150(1), 72-81.
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Shi, C., & Muneoka, K.
(1992).
Position-specific growth of mouse limb bud cells in vitro. Developmental Biology.
151(1), 9-17.
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Snyder, D. C., Coltman, B. W., Muneoka, K., & Ide, C. F.
(1991).
Mapping the early development of projections from the entorhinal cortex in the embryonic mouse using prenatal surgery techniques. Developmental Neurobiology.
22(9), 897-906.
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Wanek, N., Gardiner, D. M., Muneoka, K., & Bryant, S. V.
(1991).
Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud. Nature.
350(6313), 81-83.
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Wanek, N., Muneoka, K., Holler-Dinsmore, G., Burton, R., & Bryant, S. V.
(1989).
A staging system for mouse limb development. Journal of Experimental Zoology.
249(1), 41-49.
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Wanek, N., Muneoka, K., & Bryant, S. V.
(1989).
Evidence for regulation following amputation and tissue grafting in the developing mouse limb. Journal of Experimental Zoology.
249(1), 55-61.
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Muneoka, K., Wanek, N., & Bryant, S. V.
(1989).
Mammalian limb bud development: in situ fate maps of early hindlimb buds. Journal of Experimental Zoology.
249(1), 50-54.
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Muneoka, K., & Murad, E. H.
(1987).
Intercalation and the cellular origin of supernumerary limbs in Xenopus. Development (Cambridge).
99(4), 521-526.
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BRYANT, S. V., GARDINER, D. M., & MUNEOKA, K.
(1987).
LIMB DEVELOPMENT AND REGENERATION. AMERICAN ZOOLOGIST.
27(2), 675-696.
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Muneoka, K., Holler-Dinsmore, G., & Bryant, S. V.
(1986).
Intrinsic control of regenerative loss in Xenopus laevis limbs. Journal of Experimental Zoology.
240(1), 47-54.
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Muneoka, K., Wanek, N., & Bryant, S. V.
(1986).
Mouse embryos develop normally exo utero. Journal of Experimental Zoology.
239(2), 289-293.
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Muneoka, K., Holler-Dinsmore, G. V., & Bryant, S. V.
(1986).
Pattern discontinuity, polarity and directional intercalation in axolotl limbs. 93(1), 51-72.
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Muneoka, K., Fox, W. F., & Bryant, S. V.
(1986).
Cellular contribution from dermis and cartilage to the regenerating limb blastema in axolotls. Developmental Biology.
116(1), 256-260.
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Gardiner, D. M., Muneoka, K., & Bryant, S. V.
(1986).
The migration of dermal cells during blastema formation in axolotls. Developmental Biology.
118(2), 488-493.
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BRYANT, S. V., & MUNEOKA, K.
(1986).
VIEWS OF LIMB DEVELOPMENT AND REGENERATION. Trends in Genetics.
2(6), 153-159.
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Muneoka, K., Wanek, N., & Bryant, S. V.
(1986).
Exo utero survival of mouse embryos. Progress in clinical and biological research.
217A, 305-308.
-
Muneoka, K., Holler-Dinsmore, G., & Bryant, S.
(1986).
Regeneration from discontinuous circumferences in axolotl limbs. Progress in clinical and biological research.
217A, 61-65.
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Muneoka, K., Holler-Dinsmore, G. V., & Bryant, S. V.
(1985).
A quantitative analysis of regeneration from chimaeric limb stumps in the axolotl. 90(1), 1-12.
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Muneoka, K., & Bryant, S. V.
(1984).
Cellular contribution to supernumerary limbs in the axolotl, Ambystoma mexicanum. Developmental Biology.
105(1), 166-178.
-
Muneoka, K., & Bryant, S. V.
(1984).
Cellular contribution to supernumerary limbs resulting from the interaction between developing and regenerating tissues in the axolotl. Developmental Biology.
105(1), 179-187.
-
Muneoka, K., Wise, L. D., Fox, W. F., & Bryant, S. V.
(1984).
Improved techniques for use of the triploid cell marker in the axolotl, Ambystoma mexicanum. Developmental Biology.
105(1), 240-245.
-
Iten, L. E., Murphy, D. J., & Muneoka, K.
(1983).
Do chick limb bud cells have positional information?. Progress in clinical and biological research.
110 Pt A, 77-88.
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Muneoka, K., & Bryant, S. V.
(1982).
Evidence that patterning mechanisms in developing and regenerating limbs are the same. Nature.
298(5872), 369-371.
-
Muneoka, K.
(1980).
A new method for mechanical dechorionation of ascidian eggs. Developmental Biology.
74(2), 486-489.
-
Lin, Y., Yu, L., Yan, M., Zimmel, K., Qureshi, O., Imholt, F., ... Muneoka, K.
(2023).
Induced regeneration of articular cartilage: Identification of a dormant regeneration program for a non-regenerative tissue. dev.201894.
-
chapter
-
Muneoka, K.
(2018).
Physiological aspects of blastema formation in mice. Gardiner, D. M. (Eds.),
REGENERATIVE ENGINEERING AND DEVELOPMENTAL BIOLOGY: PRINCIPLES AND APPLICATIONS.
(pp. 139-160).
CRC Press.
-
Muneoka, K., Lai, E., Christy, R. J., & Mogford, J. E.
(2017).
Limb Regrowth and Tissue Engineering Alternatives. Full Stride.
(pp. 213-236).
Springer Nature.
-
Gardiner, D. M., Bryant, S. V., & Muneoka, K.
(2013).
Regenerative Engineering. Laurencin, C. T., & Khan, Y. (Eds.),
Regenerative Engineering.
(pp. 387-404).
Taylor & Francis.
-
Muneoka, K.
(2018).
Physiological aspects of blastema formation in mice. Gardiner, D. M. (Eds.),
REGENERATIVE ENGINEERING AND DEVELOPMENTAL BIOLOGY: PRINCIPLES AND APPLICATIONS.
(pp. 139-160).
CRC Press.
-
conference paper
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Dolan, C., Dawson, L., Imholt, F., Yang, T. J., Bohkari, R., & Muneoka, K.
(2017).
Hindlimb Unloading (HU) Inhibits Regeneration of the Mouse Digit Tip. Journal of Bone and Mineral Research.
S213-S213.
-
Brunauer, R., & Muneoka, K.
(2017).
Mouse digit regeneration: a new model to study age-related regenerative decline. Journal of Bone and Mineral Research.
S217-S217.
-
Dawson, L., Yu, L., Yan, M., Dolan, C., & Muneoka, K.
(2017).
Periosteal chondrogenesis and temporal dynamics of BMP2-induced middle phalanx regeneration in the adult mouse. Journal of Bone and Mineral Research.
S66-S66.
-
Cammack, A. J., Mandava, P., Van Meter, K., Muneoka, K., & Sammarco, M.
(2013).
Increased oxygen enhances bone degradation and promotes bone regeneration after digit amputation in mice. The FASEB Journal.
566.2-566.2.
-
Simkin, J., Sammarco, M., Fassler, D., Cammack, A., & Muneoka, K.
(2013).
Novel explant culture model for evaluation of oxygen signaling during mammalian digit regeneration. The FASEB Journal.
lb34-lb34.
-
Sammarco, M., Simkin, J., Castillo, J., & Muneoka, K.
(2012).
The role of oxygen in bone regeneration. The FASEB Journal.
758.12-758.12.
-
Ozpolat, B. D., Anderson, R., & Muneoka, K.
(2010).
Embryonic chicken model of joint regeneration recapitulates joint development. Developmental Biology.
422-423.
-
Han, M., Yang, X., Lee, J., Brownyard, C., Escudero, S., Johnson, K., Allan, C., & Muneoka, K.
(2005).
Appositional bone growth and digit regeneration in mice and humans. Developmental Biology.
640-641.
-
Dolan, C., Dawson, L., Imholt, F., Yang, T. J., Bohkari, R., & Muneoka, K.
(2017).
Hindlimb Unloading (HU) Inhibits Regeneration of the Mouse Digit Tip. Journal of Bone and Mineral Research.
S213-S213.
Teaching
teaching activities
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- VTPP291 Research Instructor
- VTPP485 Directed Studies Instructor
- VTPP491 Hnr-research Instructor
- VTPP685 Directed Studies Instructor
- VTPP691 Research Instructor
Background
education and training
- Ph.D. in Developmental and Cell Biology, University of California, Irvine - (Irvine, California, United States) 1983
- B.A. in Biology/Zoology, Humboldt State University - (Arcata, California, United States) 1976
- University of California, Irvine - (Irvine, California, United States) , Postdoctoral Training 1986
awards and honors
Contact
first name
- Ken
has last name
- Muneoka
mailing address
-
Texas A&M University
Vet Med - Physiology & Pharmacology
4466 TAMU
College Station, TX 77843-4466
USA
Other
- kmuneoka@tamu.edu