HR job title
- Professor
- Contact Info
- 1 979 862 3418
- ORCiD
- 0000-0002-8359-892X
Miranda, Rajesh Professor
Positions
My research is focused on fetal brain development, stem cells, microRNAs, and teratology. Our laboratory is interested in understanding the biological steps that transform uncommitted stem cells into neurons or a glial cells, and identifying key microRNAs that control the transformation of stem cells into neurons. We are also currently investigating what role teratogen-sensitive microRNAs play in fetal brain growth, and the spatial patterning of the emerging forebrain.
Research Areas
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Overview
Publications
selected publications
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academic article
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Pinson, M. R., Bake, S., Hurst, D. A., Samiya, N. T., Sohrabji, F., & Miranda, R. C.
(2023).
Prenatal Alcohol Alters Inflammatory Signatures In Enteric Portal Tissues Following Adult-Onset Cerebrovascular Ischemic Stroke. iScience.
26(10), 107920-107920.
-
Chung, D. D., Mahnke, A. H., Pinson, M. R., Salem, N. A., Lai, M. S., Collins, N. P., Hillhouse, A. E., & Miranda, R. C.
(2023).
Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure. 14(1), 19.
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Rouzer, S. K., Gutierrez, J., Larin, K. V., & Miranda, R. C.
(2023).
Alcohol & cannabinoid co-use: Implications for impaired fetal brain development following gestational exposure. 361, 114318-114318.
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Pinson, M. R., Tseng, A. M., Lehman, T. E., Chung, K., Gutierrez, J., Larin, K. V., ... CIFASD.
(2023).
Maternal circulating miRNAs contribute to negative pregnancy outcomes by altering placental transcriptome and fetal vascular dynamics. PLoS ONE.
18(11), e0290720-e0290720.
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Bake, S., Hurst, D. A., Miranda, R. C., & Sohrabji, F.
(2022).
Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long-term behavioral recovery from the effects of an adult-onset cerebrovascular ischemic stroke. Alcoholism: Clinical and Experimental Research.
46(12), 2267-2279.
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Chung, D. D., Pinson, M. R., Mahnke, A. H., Salem, N. A., Le, K. T., Payne, E. A., ... Miranda, R. C.
(2022).
Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure. Heliyon.
8(11), e11348-e11348.
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Pinson, M. R., Tseng, A. M., Adams, A., Lehman, T. E., Chung, K., Gutierrez, J., ... Collaborative Initiative on Fetal Alcohol Spectrum Disorders.
(2022).
Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome. Alcoholism: Clinical and Experimental Research.
46(6), 1036-1049.
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Mahnke, A. H., Roberts, M. H., Leeman, L., Ma, X., Bakhireva, L. N., & Miranda, R. C.
(2022).
Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome. Scientific Reports.
12(1), 5941.
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Pinson, M. R., Chung, D. D., Mahnke, A. H., Salem, N. A., Osorio, D., Nair, V., ... Miranda, R. C.
(2022).
Gag-like proteins: Novel mediators of prenatal alcohol exposure in neural development. Alcoholism: Clinical and Experimental Research.
46(4), 556-569.
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Pinson, M. R., Chung, D. D., Adams, A. M., Scopice, C., Payne, E. A., Sivakumar, M., & Miranda, R. C.
(2021).
Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures. Aging and Disease.
12(6), 1516-1535.
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Chung, D. D., Pinson, M. R., Bhenderu, L. S., Lai, M. S., Patel, R. A., & Miranda, R. C.
(2021).
Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood. International Journal of Molecular Sciences.
22(16), 8785-8785.
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Pinson, M. R., Holloway, K. N., Douglas, J. C., Kane, C., Miranda, R. C., & Drew, P. D.
(2021).
Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period. Alcoholism: Clinical and Experimental Research.
45(7), 1408-1423.
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Salem, N. A., Mahnke, A. H., Konganti, K., Hillhouse, A. E., & Miranda, R. C.
(2021).
Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex. iScience.
24(5), 102439-102439.
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Mahnke, A. H., Sideridis, G. D., Salem, N. A., Tseng, A. M., Carter, R. C., Dodge, N. C., ... Jacobson, J. L.
(2021).
Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders. Scientific Reports.
11(1), 1429.
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Strain, M. M., Johnston, D. T., Baine, R. E., Reynolds, J. A., Huang, Y., Henwood, M. K., ... Grau, J. W.
(2021).
Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics. JOURNAL OF NEUROTRAUMA.
38(24), 3406-3430.
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Bake, S., Pinson, M. R., Pandey, S., Chambers, J. P., Mota, R., Fairchild, A. E., Miranda, R. C., & Sohrabji, F.
(2021).
Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats. Brain, Behavior, and Immunity.
98, 86-100.
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Salem, N. A., Mahnke, A. H., Tseng, A. M., Garcia, C. R., Jahromi, H. K., Geoffroy, C. G., & Miranda, R. C.
(2021).
A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol. NEUROTOXICOLOGY AND TERATOLOGY.
83, 106943-106943.
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Raghunathan, R., Liu, C., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V.
(2020).
Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure. 25(12), 126001-126001.
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Salem, N. A., Mahnke, A. H., Wells, A. B., Tseng, A. M., Yevtushok, L., Zymak-Zakutnya, N., ... Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD).
(2020).
Association between fetal sex and maternal plasma microRNA responses to prenatal alcohol exposure: evidence from a birth outcome-stratified cohort. Biology of Sex Differences.
11(1), 51.
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Raghunathan, R., Liu, C., Ambekar, Y. S., Singh, M., Miranda, R. C., & Larin, K. V.
(2020).
Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine. Biomedical Optics Express.
11(7), 3618-3632.
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Pinson, M. R., & Miranda, R. C.
(2019).
Noncoding RNAs in development and teratology, with focus on effects of cannabis, cocaine, nicotine, and ethanol. Birth Defects Research.
111(17), 1308-1319.
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Raghunathan, R., Liu, C., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V.
(2019).
Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography. Journal of Biophotonics.
12(8), e201900050.
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Tseng, A. M., Chung, D. D., Pinson, M. R., Salem, N. A., Eaves, S. E., & Miranda, R. C.
(2019).
Ethanol Exposure Increases miR-140 in Extracellular Vesicles: Implications for Fetal Neural Stem Cell Proliferation and Maturation. Alcoholism: Clinical and Experimental Research.
43(7), 1414-1426.
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Tseng, A. M., Mahnke, A. H., Wells, A. B., Salem, N. A., Allan, A. M., Roberts, V. H., ... Collaborative Initiative on Fetal Alcohol Spectrum Disorders.
(2019).
Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation. Life Science Alliance.
2(2), e201800252-e201800252.
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Mahnke, A. H., Adams, A. M., Wang, A. Z., & Miranda, R. C.
(2019).
Toxicant and teratogenic effects of prenatal alcohol. Current Opinion in Toxicology.
14, 29-34.
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Bake, S., Miranda, R., & Sohrabji, F.
(2019).
Abstract WP153: Prenatal Alcohol Exposure Induces Glucose Intolerance and Exacerbates Stroke Severity in Middle-Aged Rats. Stroke.
50(Suppl_1),
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Turtle, J. D., Henwood, M. K., Strain, M. M., Huang, Y., Miranda, R. C., & Grau, J. W.
(2019).
Engaging pain fibers after a spinal cord injury fosters hemorrhage and expands the area of secondary injury. Experimental Neurology.
311, 115-124.
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Wommack, J. C., Trzeciakowski, J. P., Miranda, R. C., Stowe, R. P., & Ruiz, R. J.
(2018).
Micro RNA clusters in maternal plasma are associated with preterm birth and infant outcomes. PLoS ONE.
13(6), e0199029-e0199029.
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Cheng, Y., Wang, X., Wei, X., Xie, X., Melo, S., Miranda, R. C., & Wang, J.
(2018).
Prenatal Exposure to Alcohol Induces Functional and Structural Plasticity in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. Alcoholism: Clinical and Experimental Research.
42(8), 1493-1502.
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Raghunathan, R., Wu, C., Singh, M., Liu, C., Miranda, R. C., & Larin, K. V.
(2018).
Evaluating the effects of maternal alcohol consumption on murine fetal brain vasculature using optical coherence tomography. Journal of Biophotonics.
11(5), e201700238-e201700238.
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Bakhireva, L. N., Garrison, L., Shrestha, S., Sharkis, J., Miranda, R., & Rogers, K.
(2018).
Challenges of diagnosing fetal alcohol spectrum disorders in foster and adopted children. ALCOHOL.
67, 37-43.
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Mahnke, A. H., Miranda, R. C., & Homanics, G. E.
(2017).
Epigenetic mediators and consequences of excessive alcohol consumption. ALCOHOL.
60, 1-6.
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Balaraman, S., Idrus, N. M., Miranda, R. C., & Thomas, J. D.
(2017).
Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure. ALCOHOL.
60, 159-167.
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Bakhireva, L. N., Sharkis, J., Shrestha, S., Miranda-Sohrabji, T. J., Williams, S., & Miranda, R. C.
(2017).
Prevalence of Prenatal Alcohol Exposure in the State of Texas as Assessed by Phosphatidylethanol in Newborn Dried Blood Spot Specimens. Alcoholism: Clinical and Experimental Research.
41(5), 1004-1011.
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Burrowes, S. G., Salem, N. A., Tseng, A. M., Balaraman, S., Pinson, M. R., Garcia, C., & Miranda, R. C.
(2017).
The BAF (BRG1/BRM-Associated Factor) chromatin-remodeling complex exhibits ethanol sensitivity in fetal neural progenitor cells and regulates transcription at the miR-9-2 encoding gene locus. ALCOHOL.
60, 149-158.
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Grau, J. W., Huang, Y., Turtle, J. D., Strain, M. M., Miranda, R. C., Garraway, S. M., & Hook, M. A.
(2017).
When Pain Hurts: Nociceptive Stimulation Induces a State of Maladaptive Plasticity and Impairs Recovery after Spinal Cord Injury. JOURNAL OF NEUROTRAUMA.
34(10), 1873-1890.
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Bake, S., Gardner, R., Tingling, J. D., Miranda, R. C., & Sohrabji, F.
(2017).
Fetal Alcohol Exposure Alters Blood Flow and Neurological Responses to Transient Cerebral Ischemia in Adult Mice. Alcoholism: Clinical and Experimental Research.
41(1), 117-127.
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Balaraman, S., Schafer, J. J., Tseng, A. M., Wertelecki, W., Yevtushok, L., Zymak-Zakutnya, N., Chambers, C. D., & Miranda, R. C.
(2016).
Plasma miRNA Profiles in Pregnant Women Predict Infant Outcomes following Prenatal Alcohol Exposure. PLoS ONE.
11(11), e0165081-e0165081.
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Lunde, E. R., Washburn, S. E., Golding, M. C., Bake, S., Miranda, R. C., & Ramadoss, J.
(2016).
Alcohol-Induced Developmental Origins of Adult-Onset Diseases. Alcoholism: Clinical and Experimental Research.
40(7), 1403-1414.
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Veazey, K. J., Parnell, S. E., Miranda, R. C., & Golding, M. C.
(2015).
Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. Epigenetics and Chromatin.
8(1), 39.
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Candelaria, N. R., Weldon, R., Muthusamy, S., Nguyen-Vu, T., Addanki, S., Yoffou, P., ... Lin, C.
(2015).
Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells. PLoS ONE.
10(12), e0145061-e0145061.
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Thomas, J. D., Balaraman, S. R., Idrus, N. M., & Miranda, R. C.
(2015).
FOC3FASDFOC3-1POSTNATAL CHOLINE SUPPLEMENTATION MODIFIES ALTERATIONS IN miRNAs INDUCED BY DEVELOPMENTAL ALCOHOL EXPOSURE. Alcohol and Alcoholism.
50(suppl_1), i38-i38.
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Chisholm, N. C., Henderson, M. L., Selvamani, A., Park, M. J., Dindot, S., Miranda, R. C., & Sohrabji, F.
(2015).
Histone methylation patterns in astrocytes are influenced by age following ischemia. Epigenetics.
10(2), 142-152.
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Garraway, S. M., Woller, S. A., Huie, J. R., Hartman, J. J., Hook, M. A., Miranda, R. C., ... Grau, J. W.
(2014).
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis. Pain.
155(11), 2344-2359.
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Strickland, E. R., Woller, S. A., Hook, M. A., Grau, J. W., & Miranda, R. C.
(2014).
The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.
77, 40-49.
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Grau, J. W., Huie, J. R., Lee, K. H., Hoy, K. C., Huang, Y., Turtle, J. D., ... Garraway, S. M.
(2014).
Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury. Frontiers in Neural Circuits.
8(SEP), 100.
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Strickland, E. R., Woller, S. A., Garraway, S. M., Hook, M. A., Grau, J. W., & Miranda, R. C.
(2014).
Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion. Frontiers in Neural Circuits.
8, 117.
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Selvamani, A., Williams, M. H., Miranda, R. C., & Sohrabji, F.
(2014).
Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model. Clinical Science.
127(2), 77-89.
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Tsai, P., Bake, S., Balaraman, S., Rawlings, J., Holgate, R. R., Dubois, D., & Miranda, R. C.
(2014).
MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells. Biology Open.
3(8), 741-758.
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Balaraman, S., Lunde, E. R., Sawant, O., Cudd, T. A., Washburn, S. E., & Miranda, R. C.
(2014).
Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model. Alcoholism: Clinical and Experimental Research.
38(5), 1390-1400.
-
Miranda, R. C.
(2014).
MicroRNAs and ethanol toxicity. 115, 245-284.
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Miranda, R. C., Kable, J., Reynolds, J. N., & Valenzuela, C. F.
(2013).
A report on the Fetal Alcohol Spectrum Disorders Study Group meeting of 2012, theme title, "Biomarkers for FASD". ALCOHOL.
47(8), 583-587.
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Balaraman, S., Tingling, J. D., Tsai, P., & Miranda, R. C.
(2013).
Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. Alcohol research : current reviews.
35(1), 18-24.
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Pappalardo-Carter, D. L., Balaraman, S., Sathyan, P., Carter, E. S., Chen, W., & Miranda, R. C.
(2013).
Suppression and epigenetic regulation of MiR-9 contributes to ethanol teratology: evidence from zebrafish and murine fetal neural stem cell models. Alcoholism: Clinical and Experimental Research.
37(10), 1657-1667.
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Veazey, K. J., Carnahan, M. N., Muller, D., Miranda, R. C., & Golding, M. C.
(2013).
Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation. Alcoholism: Clinical and Experimental Research.
37(7), 1111-1122.
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Tingling, J. D., Bake, S., Holgate, R., Rawlings, J., Nagsuk, P. P., Chandrasekharan, J., Schneider, S. L., & Miranda, R. C.
(2013).
CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models. PLoS ONE.
8(7), e69560-e69560.
-
Sudheendran, N., Bake, S., Miranda, R. C., & Larin, K. V.
(2013).
Comparative assessments of the effects of alcohol exposure on fetal brain development using optical coherence tomography and ultrasound imaging. Journal of Biomedical Optics.
18(2), 20506-020506.
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Carnahan, M. N., Veazey, K. J., Muller, D., Tingling, J. D., Miranda, R. C., & Golding, M. C.
(2013).
Identification of cell-specific patterns of reference gene stability in quantitative reverse-transcriptase polymerase chain reaction studies of embryonic, placental and neural stem models of prenatal ethanol exposure. ALCOHOL.
47(2), 109-120.
-
Miranda, R. C.
(2012).
MicroRNAs and Fetal Brain Development: Implications for Ethanol Teratology during the Second Trimester Period of Neurogenesis. Frontiers in Genetics.
3(MAY), 77.
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Balaraman, S., Winzer-Serhan, U. H., & Miranda, R. C.
(2012).
Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. Alcoholism: Clinical and Experimental Research.
36(10), 1669-1677.
-
Bake, S., Tingling, J. D., & Miranda, R. C.
(2012).
Ethanol exposure during pregnancy persistently attenuates cranially directed blood flow in the developing fetus: evidence from ultrasound imaging in a murine second trimester equivalent model. Alcoholism: Clinical and Experimental Research.
36(5), 748-758.
-
Selvamani, A., Sathyan, P., Miranda, R. C., & Sohrabji, F.
(2012).
An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS ONE.
7(2), e32662-e32662.
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Kane, C., Smith, S. M., Miranda, R. C., & Kable, J.
(2012).
Proceedings of the 2010 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group. ALCOHOL.
46(1), 107-114.
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Strickland, E. R., Hook, M. A., Balaraman, S., Huie, J. R., Grau, J. W., & Miranda, R. C.
(2011).
MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair. 186, 146-160.
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Miranda, R. C.
(2011).
Commentary: will analyzing the epigenome yield cohesive principles of ethanol teratology?. Alcoholism: Clinical and Experimental Research.
35(7), 1201-1203.
-
Miranda, R. C., Pietrzykowski, A. Z., Tang, Y., Sathyan, P., Mayfield, D., Keshavarzian, A., Sampson, W., & Hereld, D.
(2010).
MicroRNAs: master regulators of ethanol abuse and toxicity?. Alcoholism: Clinical and Experimental Research.
34(4), 575-587.
-
Camarillo, C., & Miranda, R. C.
(2008).
Ethanol exposure during neurogenesis induces persistent effects on neural maturation: evidence from an ex vivo model of fetal cerebral cortical neuroepithelial progenitor maturation. 14(3), 159-171.
-
Sathyan, P., & Miranda, R. C.
(2008).
[P2.21]: A teratogensensitive microRNA, miR335 controls the maturation of foetal neuroepithelial progenitors. International Journal of Developmental Neuroscience.
26(8), 873-874.
-
Ferguson, A. R., Bolding, K. A., Huie, J. R., Hook, M. A., Santillano, D. R., Miranda, R. C., & Grau, J. W.
(2008).
Group I metabotropic glutamate receptors control metaplasticity of spinal cord learning through a protein kinase C-dependent mechanism. 28(46), 11939-11949.
-
Miranda, R. C., Santillano, D. R., Camarillo, C., & Dohrman, D.
(2008).
Modeling the impact of alcohol on cortical development in a dish: strategies from mapping neural stem cell fate. Methods in molecular biology (Clifton, N.J.).
447, 151-168.
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Sathyan, P., Golden, H. B., & Miranda, R. C.
(2007).
Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. 27(32), 8546-8557.
-
Prock, T. L., & Miranda, R. C.
(2007).
Embryonic cerebral cortical progenitors are resistant to apoptosis, but increase expression of suicide receptor DISC-complex genes and suppress autophagy following ethanol exposure. Alcoholism: Clinical and Experimental Research.
31(4), 694-703.
-
Camarillo, C., Kumar, L. S., Bake, S., Sohrabji, F., & Miranda, R. C.
(2007).
Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation. Alcoholism: Clinical and Experimental Research.
31(2), 324-335.
-
Grau, J. W., Crown, E. D., Ferguson, A. R., Washburn, S. N., Hook, M. A., & Miranda, R. C.
(2006).
Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery after injury. Behavioral and Cognitive Neuroscience Reviews.
5(4), 191-239.
-
Santillano, D. R., Kumar, L. S., Prock, T. L., Camarillo, C., Tingling, J. D., & Miranda, R. C.
(2005).
Ethanol induces cell-cycle activity and reduces stem cell diversity to alter both regenerative capacity and differentiation potential of cerebral cortical neuroepithelial precursors. BMC Neuroscience.
6(1), 59.
-
Tang, L. S., Santillano, D. R., Wlodarczyk, B. J., Miranda, R. C., & Finnell, R. H.
(2005).
Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies. American Journal of Medical Genetics Part C: Seminars in Medical Genetics.
135C(1), 48-58.
-
Liu, G. T., Ferguson, A. R., Crown, E. D., Bopp, A. C., Miranda, R. C., & Grau, J. W.
(2005).
Instrumental learning within the rat spinal cord: localization of the essential neural circuit. BEHAVIORAL NEUROSCIENCE.
119(2), 538-547.
-
Grau, J. W., Washburn, S. N., Hook, M. A., Ferguson, A. R., Crown, E. D., Garcia, G., Bolding, K. A., & Miranda, R. C.
(2004).
Uncontrollable stimulation undermines recovery after spinal cord injury. JOURNAL OF NEUROTRAUMA.
21(12), 1795-1817.
-
Tang, L. S., Wlodarczyk, B. J., Santillano, D. R., Miranda, R. C., & Finnell, R. H.
(2004).
Developmental consequences of abnormal folate transport during murine heart morphogenesis. 70(7), 449-458.
-
Hsiao, S., DuBois, D. W., Miranda, R. C., & Frye, G. D.
(2004).
Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro. BRAIN RESEARCH.
1008(1), 69-80.
-
Cheema, Z. F., Santillano, D. R., Wade, S. B., Newman, J. M., & Miranda, R. C.
(2004).
The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins. BMC Neuroscience.
5(1), 11-11.
-
Anderson, R., Harting, E., Frey, M. S., Leibowitz, J. L., & Miranda, R. C.
(2000).
Theiler's murine encephalomyelitis virus induces rapid necrosis and delayed apoptosis in myelinated mouse cerebellar explant cultures. BRAIN RESEARCH.
868(2), 259-267.
-
Craig, J. C., Bennett, G. D., Miranda, R. C., Mackler, S. A., & Finnell, R. H.
(2000).
Ribonucleotide reductase subunit R1: a gene conferring sensitivity to valproic acid-induced neural tube defects in mice. 61(4), 305-313.
-
Cheema, Z. F., West, J. R., & Miranda, R. C.
(2000).
Ethanol induces Fas/Apo [apoptosis]-1 mRNA and cell suicide in the developing cerebral cortex. 24(4), 535-543.
-
McAlhany, R. E., West, J. R., & Miranda, R. C.
(2000).
Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phosphorylation. Brain research. Developmental brain research.
119(2), 209-216.
-
McAlhany, R. E., Miranda, R. C., Finnell, R. H., & West, J. R.
(1999).
Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum. 23(10), 1691-1697.
-
Wade, S. B., Oommen, P., Conner, W. C., Earnest, D. J., & Miranda, R. C.
(1999).
Overlapping and divergent actions of estrogen and the neurotrophins on cell fate and p53-dependent signal transduction in conditionally immortalized cerebral cortical neuroblasts. The Journal of Neuroscience.
19(16), 6994-7006.
-
Cheema, Z. F., Wade, S. B., Sata, M., Walsh, K., Sohrabji, F., & Miranda, R. C.
(1999).
Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. The Journal of Neuroscience.
19(5), 1754-1770.
-
Liang, F. Q., Sohrabji, F., Miranda, R., Earnest, B., & Earnest, D.
(1998).
Expression of brain-derived neurotrophic factor and its cognate receptor, TrkB, in the rat suprachiasmatic nucleus. Experimental Neurology.
151(2), 184-193.
-
McAlhany, R. E., West, J. R., & Miranda, R. C.
(1997).
Glial-derived neurotrophic factor rescues calbindin-D28k-immunoreactive neurons in alcohol-treated cerebellar explant cultures. Developmental Neurobiology.
33(6), 835-847.
-
Sohrabji, F., & Miranda, R. C.
(1997).
Hormone replacement: Therapeutic strategies in the treatment of Alzheimer's disease and ageing-related cognitive disorders. Expert Opinion on Therapeutic Patents.
7(6), 611-629.
-
Miranda, R., Sohrabji, F., Singh, M., & Toran-Allerand, D.
(1996).
Nerve growth factor (NGF) regulation of estrogen receptors in explant cultures of the developing forebrain. Developmental Neurobiology.
31(1), 77-87.
-
Sohrabji, F., Miranda, R. C., & Toran-Allerand, C. D.
(1995).
Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences of the United States of America.
92(24), 11110-11114.
-
Donovan, M. J., Miranda, R. C., Kraemer, R., McCaffrey, T. A., Tessarollo, L., Mahadeo, D., ... Parada, L.
(1995).
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. American Journal of Pathology.
147(2), 309-324.
-
Miranda, R. C., Sohrabji, F., & Toran-Allerand, D.
(1994).
Interactions of estrogen with the neurotrophins and their receptors during neural development. Hormones and Behaviour.
28(4), 367-375.
-
Sohrabji, F., Greene, L. A., Miranda, R. C., & Toran-Allerand, C. D.
(1994).
Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. Developmental Neurobiology.
25(8), 974-988.
-
Sohrabji, F., Miranda, R. C., & Toran-Allerand, C. D.
(1994).
Estrogen Differentially Regulates Estrogen and Nerve Growth Factor Receptor mRNAs in Adult Sensory Neurons. Obstetrical and Gynecological Survey.
49(7), 495-497.
-
Sohrabji, F., Miranda, R. C., & Toran-Allerand, C. D.
(1994).
Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons. 14(2), 459-471.
-
Miranda, R. C., Sohrabji, F., & Toran-Allerand, C. D.
(1993).
Presumptive Estrogen Target Neurons Express mRNAs for both the Neurotrophins and Neurotrophin Receptors: A Basis for Potential Developmental Interactions of Estrogen with the Neurotrophins. Molecular and Cellular Neuroscience.
4(6), 510-525.
-
Miranda, R. C., Sohrabji, F., & Toran-Allerand, C. D.
(1993).
Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. Proceedings of the National Academy of Sciences of the United States of America.
90(14), 6439-6443.
-
Toran-Allerand, C. D., Miranda, R. C., Bentham, W. D., Sohrabji, F., Brown, T. J., Hochberg, R. B., & MacLusky, N. J.
(1992).
Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proceedings of the National Academy of Sciences of the United States of America.
89(10), 4668-4672.
-
Toran-Allerand, C. D., Miranda, R. C., Hochberg, R. B., & MacLusky, N. J.
(1992).
Cellular variations in estrogen receptor mRNA translation in the developing brain: evidence from combined [125I]estrogen autoradiography and non-isotopic in situ hybridization histochemistry. BRAIN RESEARCH.
576(1), 25-41.
-
Miranda, R. C., & Toran-Allerand, C. D.
(1992).
Developmental expression of estrogen receptor mRNA in the rat cerebral cortex: a nonisotopic in situ hybridization histochemistry study. Cerebral Cortex.
2(1), 1-15.
-
Toran-Allerand, C. D., Bentham, W., Miranda, R. C., & Anderson, J. P.
(1991).
Insulin influences astroglial morphology and glial fibrillary acidic protein (GFAP) expression in organotypic cultures. BRAIN RESEARCH.
558(2), 296-304.
-
Miranda, R., Ceckler, T., Guillet, R., & Kellogg, C. K.
(1990).
Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam. Neurobiology of Aging.
11(2), 117-122.
-
Miranda, R., Ceckler, T., Guillet, R., & Kellogg, C.
(1990).
Early developmental exposure to benzodiazepine ligands alters brain 31P-NMR spectra in young adult rats. BRAIN RESEARCH.
506(1), 85-92.
-
Miranda, R. C., Wagner, J. P., & Kellogg, C. K.
(1989).
Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats. Neurochemical Research.
14(11), 1119-1127.
-
Pinson, M. R., Bake, S., Hurst, D. A., Samiya, N. T., Sohrabji, F., & Miranda, R. C.
(2023).
Prenatal Alcohol Alters Inflammatory Signatures In Enteric Portal Tissues Following Adult-Onset Cerebrovascular Ischemic Stroke. iScience.
26(10), 107920-107920.
-
chapter
-
Mahnke, A. H., Miranda, R. C., & Mooney, S. M.
(2020).
Chapter 7 Fetal alcohol spectrum disorders. Neurodevelopmental Disorders.
(pp. 159-178).
Elsevier.
-
Mahnke, A. H., Salem, N. A., Tseng, A. M., Fincher, A. S., Klopfer, A., & Miranda, R. C.
(2018).
Fetal Alcohol Spectrum Disorders: A StemCellopathy?. Stem Cells in Birth Defects Research and Developmental Toxicology.
(pp. 223-259).
Wiley.
-
Tseng, A. M., Mahnke, A. H., Salem, N. A., & Miranda, R. C.
(2018).
NONCODING RNA REGULATORY NETWORKS, EPIGENETICS, AND PROGRAMMING STEM CELL RENEWAL AND DIFFERENTIATION: IMPLICATIONS FOR STEM CELL THERAPY. EPIGENETICS IN HUMAN DISEASE, 2ND EDITION.
(pp. 903-933).
Elsevier.
-
Mahnke, A. H., Salem, N. A., Tseng, A. M., Chung, D. D., & Miranda, R. C.
(2018).
Nonprotein-coding RNAs in Fetal Alcohol Spectrum Disorders. EPIGENETICS AND PSYCHIATRIC DISEASE.
(pp. 299-342).
Elsevier.
-
Miranda, R. C., Salem, N. A., Fincher, A. S., Mahnke, A. H., & Burrowes, S. G.
(2016).
Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease. MEDICAL EPIGENETICS.
(pp. 531-552).
Elsevier.
-
Miranda, R. C., & Balaraman, S.
(2014).
Chapter 24 MicroRNAs in Alcohol Abuse and Toxicity. Neurobiology of Alcohol Dependence.
(pp. 497-521).
Elsevier.
-
Miranda, R. C., & Balaraman, S.
(2014).
MicroRNAs in Alcohol Abuse and Toxicity. Neurobiology of Alcohol Dependence.
(pp. 497-521).
Elsevier.
-
Miranda, R. C.
(2012).
Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy. EPIGENETICS IN HUMAN DISEASE.
(pp. 503-518).
Elsevier.
-
Miranda, R. C.
(2012).
Chapter 25 Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation Implications for Stem Cell Therapy. Epigenetics in Human Disease.
(pp. 503-518).
Elsevier.
-
Miranda, R. C., & Sohrabji, F.
(1996).
Gonadal steroid receptors: Possible roles in the etiology and therapy of cognitive and neurological disorders. Annual Reports in Medicinal Chemistry.
Annual Reports in Medicinal Chemistry.
(pp. 11-20).
Elsevier.
-
Mahnke, A. H., Miranda, R. C., & Mooney, S. M.
(2020).
Chapter 7 Fetal alcohol spectrum disorders. Neurodevelopmental Disorders.
(pp. 159-178).
Elsevier.
-
conference paper
-
Raghunathan, R., Liu, C., Gutierrez, J., Singh, M., Miranda, R. C., & Larin, K. V.
(2021).
Optical coherence angiography to assess the combined effects of alcohol and nicotine on fetal brain vasculature. Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
116300a-116300a-5.
-
Raghunathan, R., Liu, C., Singh, M., Miranda, R. C., & Larin, K. V.
(2021).
A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
1164109-1164109-5.
-
Salem, N. A., Mahnke, A. H., Konganti, K., Hillhouse, A. E., & Miranda, R. C.
(2021).
CELL-TYPE AND SEX-SPECIFIC TARGETS OF PRENATAL ALCOHOL EXPOSURE IN THE DEVELOPING MOUSE CEREBRAL CORTEX: IDENTIFICATION OF NOVEL MECHANISMS FOR TERATOGENESIS. Alcoholism: Clinical and Experimental Research.
99A-99A.
-
Mahnke, A. H., Pinson, M. R., Tseng, A. M., Wells, A. B., Chambers, C. D., & Miranda, R. C.
(2021).
CIRCULATING MICRORNA BIOMARKERS FOR INFANT NEURODEVELOPMENTAL DEFICITS DUE TO PRENATAL ALCOHOL EXPOSURE. Alcoholism: Clinical and Experimental Research.
29A-29A.
-
Raghunathan, R., Liu, C., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V.
(2019).
In utero optical coherence tomography reveals changes in murine embryonic brain vasculature after prenatal cannabinoid exposure. Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
108671x.
-
Mahnke, A. H., Leeman, L., Luo, L., Abdelfattah, A., Shrestha, S., Miranda, R. C., & Bakhireva, L. N.
(2019).
Neonatal Cord Blood miRNAs As Biomarkers of Neonatal Opioid Withdrawal Syndrome. Birth Defects Research.
493-493.
-
Raghunathan, R., Wu, C., Singh, M., Liu, C., Miranda, R. C., & Larin, K. V.
(2017).
Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography. Proceedings of SPIE.
103401g-103401g-1.
-
Miranda, R. C.
(2017).
Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs). NEUROTOXICOLOGY AND TERATOLOGY.
149-150.
-
Miranda, R. C.
(2017).
Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs). Birth Defects Research.
632-632.
-
Miranda, R. C., & Tsai, P.
(2014).
Mechanisms of microRNA function in fetal neural stem cells: implications for ethanol teratology. NEUROTOXICOLOGY AND TERATOLOGY.
82-82.
-
Sudheendran, N., Bake, S., Miranda, R. C., & Larin, K. V.
(2014).
Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain. Proceedings of SPIE.
89530d-89530d-5.
-
Raghunathan, R., Liu, C., Gutierrez, J., Singh, M., Miranda, R. C., & Larin, K. V.
(2021).
Optical coherence angiography to assess the combined effects of alcohol and nicotine on fetal brain vasculature. Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
116300a-116300a-5.
-
institutional repository document
-
Rouzer, S. K., Sreeram, A., & Miranda, R.
(2023).
Reduced fetal cerebral blood flow following prenatal drug exposure predicts perinatal mortality
-
Tseng, A. M., Mahnke, A. H., Wells, A. B., Salem, N. A., Allan, A. M., Roberts, V., ... CIFASD.
(2018).
Maternal Circulating MiRNAs That Predict Infant FASD Outcomes Influence Placental Maturation
-
Rouzer, S. K., Sreeram, A., & Miranda, R.
(2023).
Reduced fetal cerebral blood flow following prenatal drug exposure predicts perinatal mortality
Research
principal investigator on
- Prenatal alcohol/cannabinoid co-exposures and fetal brain development awarded by National Institute On Alcohol Abuse and Alcoholism - (Bethesda, Maryland, United States) 2020 - 2025
- Gag-like Proteins in Exosome-mediated Neural Development and Fetal Alcohol Spectrum Disorders awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2025
- Prenatal microRNA Neuro-Therapeutics for Fetal Alcohol Exposure awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2021
- From FASD to AUDs: Strategies for Preventing Alcohol Addictions awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2020
- Maternal Circulating miRNA Function In Fetal Alcohol Spectrum Disorders awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2019
co-principal investigator on
- Nociceptive Input After Spinal Cord Injury (SCI) Expands the Region of Secondary Injury and Undermines Long-Term Recovery awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Prenatal Alcohol and Stroke Susceptibility in the Aging Adult with FASD awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- How and when does peripheral input affect recovery after SCI awarded by Craig H Neilsen Foundation - (Los Angeles, California, United States) 2014 - 2018
investigator on
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIMS491 Research Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT684 Directed Prof Internshp Instructor
- BIOT685 Directed Studies Instructor
- GENE491 Hnr-research Instructor
- GENE691 Research Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC691 Research Instructor
Works By Students
chaired theses and dissertations
-
Al Muhisen, Hadil Mahdi J (2018-08). Sex Differences in Fetal Neural Stem Cells' Response to Ethanol.
-
Holgate, Rhonda Renay (2015-04). Ethanol Targeting nELAVs: Implications for Neural Stem Cell Maturation.
-
Raymond, Elizabeth S (2016-07). Effects of the Developmental Teratogens Ethanol and Nicotine on Long Noncoding RNA Expression in Mouse Fetal Neural Stem Cells of the Cortex.
-
Strickland, Eric (2013-05). MicroRNA Dysregulation Following Spinal Cord Contusion: Implications for Neural Plasticity and Neuropathic Pain.
-
Tsai, Pai Chi (2014-05). miR-153 and miR-335, Ethanol Sensitive MicroRNAs, Control NSC/NPC Maturation during Fetal Brain Development.
Background
education and training
- Ph.D. in Psychology, University of Rochester - (Rochester, New York, United States) 1998
Contact
first name
- Rajesh
has last name
- Miranda
mailing address
-
Texas A&M Health Science Center
Neuroscience & Experimental Therapeutics
1359 TAMUS
College Station, TX 77843-1114
USA
Other
- rmiranda@tamu.edu