HR job title
- Professor
- Contact Info
- ORCiD
- 0000-0002-0105-9034
Hettema, John Professor
Positions
- Professor, Psychiatry and Behavioral Sciences, School of Medicine
I am Professor in the Department of Psychiatry at Texas A&M Health Sciences Center and affiliate faculty member at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). As a clinician-scientist, I have participate in patient care, clinical teaching, and research activities. Before coming to TAMU in 2019, I directed the VCU Anxiety Disorders Specialty Clinic for 19 years, providing residency training and patient care via the assessment and treatment of all the major anxiety and related disorders. My research efforts focus on the epidemiology, genetics, and biology of the anxiety and related internalizing disorders. I have extensive experience applying advanced statistical genetic methodology to these questions via analyses conducted in twin, family, and population-based samples. My recent projects include conducting meta-analyses of genomewide association data on anxiety spectrum disorders (ANGST GWAS project, R01MH087646 and PGC-ANX project, R01MH113665), examining the effects of novel candidate genes derived from GWAS on internalizing psychopathology (R01MH039096), and collecting and analyzing endophenotypic measures underlying the development of internalizing disorders in a juvenile twin sample (R01MH098055). My research has been funded by NIH and private foundation grants. I am founding co-chair of the PGC-ANX Working Group which provides active collaborations with anxiety and depression researchers around the world.
Research Areas
- Overview
- Publications
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- Teaching
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Overview
Publications
selected publications
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academic article
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Lisdahl, K. M., Tapert, S., Sher, K. J., Gonzalez, R., Nixon, S. J., Feldstein Ewing, S. W., ... ABCD Consortium.
(2021).
Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study. Drug and Alcohol Dependence.
227, 108946-108946.
-
Rappaport, L. M., Di Nardo, N., Brotman, M. A., Pine, D. S., Leibenluft, E., Roberson-Nay, R., & Hettema, J. M.
(2021).
Pediatric anxiety associated with altered facial emotion recognition. Journal of Anxiety Disorders.
82, 102432-102432.
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Ma, L., Hettema, J. M., Cousijn, J., Bjork, J. M., Steinberg, J. L., Keyser-Marcus, L., ... Moeller, F. G.
(2021).
Resting-State Directional Connectivity and Anxiety and Depression Symptoms in Adult Cannabis Users. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
6(5), 545-555.
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Bourdon, J. L., Hettema, J. M., Prom-Wormley, E. C., & Southam-Gerow, M. A.
(2021).
Assessing Stakeholder Perceptions of the Utility of Genetic Information for the Clinical Care of Mental Health Disorders: We Have a Will but Need to See the Way. Administration and Policy in Mental Health and Mental Health Services Research.
48(2), 363-376.
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Qi, J., Rappaport, L. M., Cecilione, J., Hettema, J. M., & Roberson-Nay, R.
(2021).
Differential Associations of Distress Tolerance and Anxiety Sensitivity With Adolescent Internalizing Psychopathology. 50(1), 97-104.
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Purves, K. L., Coleman, J., Meier, S. M., Rayner, C., Davis, K., Cheesman, R., ... Eley, T. C.
(2020).
A major role for common genetic variation in anxiety disorders. Molecular Psychiatry.
25(12), 3292-3303.
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Rappaport, L. M., Carney, D. M., Brotman, M. A., Leibenluft, E., Pine, D. S., Roberson-Nay, R., & Hettema, J. M.
(2020).
A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes. 49(4), 524-534.
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Hettema, J. M., Bourdon, J. L., Sawyers, C., Verhulst, B., Brotman, M. A., Leibenluft, E., Pine, D. S., & Roberson-Nay, R.
(2020).
Genetic and environmental risk structure of internalizing psychopathology in youth. Depression and Anxiety.
37(6), 540-548.
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Hettema, J. M., Verhulst, B., Chatzinakos, C., Bacanu, S., Chen, C., Ursano, R. J., ... Stein, M. B.
(2020).
Genome-wide association study of shared liability to anxiety disorders in Army STARRS. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
183(4), 197-207.
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Kramer, M. D., Patrick, C. J., Hettema, J. M., Moore, A. A., Sawyers, C. K., & Yancey, J. R.
(2020).
Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure. Assessment.
27(3), 533-546.
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Ma, L., Steinberg, J. L., Bjork, J. M., Wang, Q., Hettema, J. M., Abbate, A., & Moeller, F. G.
(2020).
Altered Effective Connectivity of Central Autonomic Network in Response to Negative Facial Expression in Adults With Cannabis Use Disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
5(1), 84-96.
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Hagler, D. J., Hatton, S., Cornejo, M. D., Makowski, C., Fair, D. A., Dick, A. S., ... Dale, A. M.
(2019).
Image processing and analysis methods for the Adolescent Brain Cognitive Development Study. NEUROIMAGE.
202, 116091-116091.
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Moore, A. A., Lapato, D. M., Brotman, M. A., Leibenluft, E., Aggen, S. H., Hettema, J. M., ... Roberson-Nay, R.
(2019).
Heritability, stability, and prevalence of tonic and phasic irritability as indicators of disruptive mood dysregulation disorder. Journal of Child Psychology and Psychiatry.
60(9), 1032-1041.
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Moore, A. A., Rappaport, L. M., Blair, R. J., Pine, D. S., Leibenluft, E., Brotman, M. A., Hettema, J. M., & Roberson-Nay, R.
(2019).
Genetic underpinnings of callous-unemotional traits and emotion recognition in children, adolescents, and emerging adults. Journal of Child Psychology and Psychiatry.
60(6), 638-645.
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Savage, J. E., Moore, A. A., Sawyers, C. K., Bourdon, J. L., Verhulst, B., Carney, D. M., ... Hettema, J. M.
(2019).
Fear-potentiated startle response as an endophenotype: Evaluating metrics and methods for genetic applications. 56(5), e13325-e13325.
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Moore, A. A., Blair, R. J., Hettema, J. M., & Roberson-Nay, R.
(2019).
The genetic underpinnings of callous-unemotional traits: A systematic research review. Neuroscience and Biobehavioral Reviews.
100, 85-97.
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Sawyers, C., Ollendick, T., Brotman, M. A., Pine, D. S., Leibenluft, E., Carney, D. M., Roberson-Nay, R., & Hettema, J. M.
(2019).
The genetic and environmental structure of fear and anxiety in juvenile twins. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
180(3), 204-212.
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Bourdon, J. L., Savage, J. E., Verhulst, B., Carney, D. M., Brotman, M. A., Pine, D. S., ... Hettema, J. M.
(2019).
The Genetic and Environmental Relationship Between Childhood Behavioral Inhibition and Preadolescent Anxiety. Twin Research and Human Genetics.
22(1), 48-55.
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Tseng, W., Deveney, C. M., Stoddard, J., Kircanski, K., Frackman, A. E., Yi, J. Y., ... Leibenluft, E.
(2019).
Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths. American Journal of Psychiatry.
176(1), 67-76.
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Eastman, M. L., Moore, A. A., Cecilione, J., Hettema, J. M., & Roberson-Nay, R.
(2018).
Confirmatory factor structure and psychometric properties of the Multidimensional Peer Victimization Scale. Journal of Psychopathology and Behavioral Assessment.
40(4), 725-735.
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Bourdon, J. L., Moore, A. A., Eastman, M., Savage, J. E., Hazlett, L., Vrana, S. R., Hettema, J. M., & Roberson-Nay, R.
(2018).
Resting Heart Rate Variability (HRV) in Adolescents and Young Adults from a Genetically-Informed Perspective. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
48(5), 386-396.
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Edwards, A. C., Docherty, A. R., Moscati, A., Bigdeli, T. B., Peterson, R. E., Webb, B. T., ... Kendler, K. S.
(2018).
Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women. Psychological Medicine.
48(5), 777-789.
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Cecilione, J. L., Rappaport, L. M., Hahn, S. E., Anderson, A. E., Hazlett, L. E., Burchett, J. R., ... Roberson-Nay, R.
(2018).
Genetic and Environmental Contributions of Negative Valence Systems to Internalizing Pathways. Twin Research and Human Genetics.
21(1), 12-23.
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Rappaport, L. M., Carney, D. M., Verhulst, B., Neale, M. C., Blair, J., Brotman, M. A., ... Roberson-Nay, R.
(2018).
A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates. Journal of the American Academy of Child and Adolescent Psychiatry.
57(12), 925-933.e3.
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Eastman, M. L., Verhulst, B., Rappaport, L. M., Dirks, M., Sawyers, C., Pine, D. S., ... Roberson-Nay, R.
(2018).
Age-Related Differences in the Structure of Genetic and Environmental Contributions to Types of Peer Victimization. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
48(6), 421-431.
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Rappaport, L. M., Sheerin, C., Carney, D. M., Towbin, K. E., Leibenluft, E., Pine, D. S., ... Hettema, J. M.
(2017).
Clinical Correlates of Carbon Dioxide Hypersensitivity in Children. Journal of the American Academy of Child and Adolescent Psychiatry.
56(12), 1089-1096.e1.
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Cecilione, J. L., Rappaport, L. M., Verhulst, B., Carney, D. M., Blair, R., Brotman, M. A., ... Hettema, J. M.
(2017).
Test-retest reliability of the facial expression labeling task. PSYCHOLOGICAL ASSESSMENT.
29(12), 1537-1542.
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Michalska, K. J., Machlin, L., Moroney, E., Lowet, D. S., Hettema, J. M., Roberson-Nay, R., ... Pine, D. S.
(2017).
Anxiety symptoms and children's eye gaze during fear learning. Journal of Child Psychology and Psychiatry.
58(11), 1276-1286.
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Lee, M., Aggen, S. H., Carney, D. M., Hahn, S., Moroney, E., Machlin, L., ... Hettema, J. M.
(2017).
Latent structure of negative valence measures in childhood. 34(8), 742-751.
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Rappaport, L. M., Sheerin, C., Savage, J. E., Hettema, J. M., & Roberson-Nay, R.
(2017).
Clinical characteristics of latent classes of CO2 hypersensitivity in adolescents and young adults. Behaviour Research and Therapy.
93, 95-103.
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Tseng, W., Moroney, E., Machlin, L., Roberson-Nay, R., Hettema, J. M., Carney, D., ... Brotman, M. A.
(2017).
Test-retest reliability and validity of a frustration paradigm and irritability measures. JOURNAL OF AFFECTIVE DISORDERS.
212, 38-45.
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Moore, A. A., Carney, D., Moroney, E., Machlin, L., Towbin, K. E., Brotman, M. A., ... Hettema, J. M.
(2017).
The Inventory of Callous-Unemotional Traits (ICU) in Children: Reliability and Heritability. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
47(2), 141-151.
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Savage, J. E., Sawyers, C., Roberson-Nay, R., & Hettema, J. M.
(2017).
The genetics of anxiety-related negative valence system traits. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
174(2), 156-177.
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Lee, M., Aggen, S. H., Otowa, T., Castelao, E., Preisig, M., Grabe, H. J., ... Hettema, J. M.
(2016).
Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. International Journal of Methods in Psychiatric Research.
25(4), 255-266.
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Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., ... Hettema, J. M.
(2016).
Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry.
21(10), 1485-1485.
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Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., ... Hettema, J. M.
(2016).
Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry.
21(10), 1391-1399.
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Carney, D. M., Moroney, E., Machlin, L., Hahn, S., Savage, J. E., Lee, M., ... Hettema, J. M.
(2016).
The Twin Study of Negative Valence Emotional Constructs. Twin Research and Human Genetics.
19(5), 456-464.
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van den Berg, S. M., de Moor, M., Verweij, K., Krueger, R. F., Luciano, M., Arias Vasquez, A., ... Boomsma, D. I.
(2016).
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
46(2), 170-182.
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Hettema, J. M.
(2016).
Psychophysiology of threat response, paradigm shifts in psychiatry, and RDoC: Implications for genetic investigation of psychopathology. 53(3), 348-350.
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Hettema, J. M., Aggen, S. H., Kubarych, T. S., Neale, M. C., & Kendler, K. S.
(2015).
Identification and validation of mixed anxiety-depression. 45(14), 3075-3084.
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Fredrikson, M., Annas, P., & Hettema, J. M.
(2015).
Different genetic factors underlie fear conditioning and episodic memory. Psychiatric Genetics.
25(4), 155-162.
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Hettema, J. M., Chen, X., Sun, C., & Brown, T. A.
(2015).
Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology. 45(10), 2227-2236.
-
Shimada-Sugimoto, M., Otowa, T., & Hettema, J. M.
(2015).
Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans. Psychiatry and Clinical Neurosciences.
69(7), 388-401.
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Genetics of Personality Consortium, .., de Moor, M., van den Berg, S. M., Verweij, K., Krueger, R. F., Luciano, M., ... Boomsma, D. I.
(2015).
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry.
72(7), 642-650.
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Savage, J. E., McMichael, O., Gorlin, E. I., Beadel, J. R., Teachman, B., Vladimirov, V. I., Hettema, J. M., & Roberson-Nay, R.
(2015).
Validation of candidate anxiety disorder genes using a carbon dioxide challenge task. Biological Psychology.
109, 61-66.
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Davies, M. N., Verdi, S., Burri, A., Trzaskowski, M., Lee, M., Hettema, J. M., ... Spector, T. D.
(2015).
Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression. PLoS ONE.
10(8), e0134865-e0134865.
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Bergin, J., Verhulst, B., Aggen, S. H., Neale, M. C., Kendler, K. S., Bienvenu, O. J., & Hettema, J. M.
(2014).
Obsessive compulsive symptom dimensions and neuroticism: An examination of shared genetic and environmental risk. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
165B(8), 647-653.
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Otowa, T., York, T. P., Gardner, C. O., Kendler, K. S., & Hettema, J. M.
(2014).
The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins. Psychiatry Research.
220(1-2), 404-409.
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Loken, E. K., Hettema, J. M., Aggen, S. H., & Kendler, K. S.
(2014).
The structure of genetic and environmental risk factors for fears and phobias. Psychological Medicine.
44(11), 2375-2384.
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Otowa, T., Maher, B. S., Aggen, S. H., McClay, J. L., van den Oord, E. J., & Hettema, J. M.
(2014).
Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. PLoS ONE.
9(11), e112559-e112559.
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Otowa, T., Gardner, C. O., Kendler, K. S., & Hettema, J. M.
(2013).
Parenting and risk for mood, anxiety and substance use disorders: a study in population-based male twins. Social Psychiatry and Psychiatric Epidemiology: the international journal for research in social and genetic epidemiology and mental health services.
48(11), 1841-1849.
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Hettema, J. M., An, S., van den Oord, E., Neale, M. C., Kendler, K. S., & Chen, X.
(2013).
Genetic association between RGS1 and internalizing disorders. Psychiatric Genetics.
23(2), 56-60.
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Hettema, J. M., Sun, C., Chen, X., & Kendler, K. S.
(2013).
Genetic association study between RGS2 and anxiety-related phenotypes. Psychiatric Genetics.
23(2), 92-92.
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Webb, B. T., Guo, A., Maher, B. S., Zhao, Z., van den Oord, E. J., Kendler, K. S., ... Hettema, J. M.
(2012).
Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics.
20(10), 1078-1084.
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Vieweg, W., Hasnain, M., Howland, R. H., Hettema, J. M., Kogut, C., Wood, M. A., & Pandurangi, A. K.
(2012).
Citalopram, QTc interval prolongation, and torsade de pointes. How should we apply the recent FDA ruling?. American Journal of Medicine.
125(9), 859-868.
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Adkins, D. E., Clark, S. L., berg, K., Hettema, J. M., Bukszr, J., McClay, J. L., Souza, R. P., & van den Oord, E.
(2012).
Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. Translational Psychiatry.
2(7), e129-e129.
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Clark, S. L., Adkins, D. E., Aberg, K., Hettema, J. M., McClay, J. L., Souza, R. P., & van den Oord, E.
(2012).
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. Psychological Medicine.
42(6), 1151-1162.
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Roberson-Nay, R., Eaves, L. J., Hettema, J. M., Kendler, K. S., & Silberg, J. L.
(2012).
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. 29(4), 320-327.
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Donner, J., Sipil, T., Ripatti, S., Kananen, L., Chen, X., Kendler, K. S., ... Hovatta, I.
(2012).
Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
159B(3), 316-327.
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Hettema, J. M., Kettenmann, B., Ahluwalia, V., McCarthy, C., Kates, W. R., Schmitt, J. E., ... Fatouros, P.
(2012).
Pilot multimodal twin imaging study of generalized anxiety disorder. 29(3), 202-209.
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Tambs, K., Kendler, K. S., Reichborn-Kjennerud, T., Aggen, S. H., Harris, J. R., Neale, M. C., ... Rysamb, E.
(2012).
Genetic and environmental contributions to the relationship between education and anxiety disorders - a twin study. ACTA PSYCHIATRICA SCANDINAVICA.
125(3), 203-212.
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Libert, S., Pointer, K., Bell, E. L., Das, A., Cohen, D. E., Asara, J. M., ... Guarente, L.
(2011).
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell.
147(7), 1459-1472.
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Hettema, J. M., Webb, B. T., Guo, A., Zhao, Z., Maher, B. S., Chen, X., ... van den Oord, E. J.
(2011).
Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders. Biological Psychiatry.
70(9), 888-896.
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Maher, B. S., Vladimirov, V. I., Latendresse, S. J., Thiselton, D. L., McNamee, R., Kang, M., ... Vanyukov, M. M.
(2011).
The AVPR1A gene and substance use disorders: association, replication, and functional evidence. Biological Psychiatry.
70(6), 519-527.
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Schienle, A., Hettema, J. M., Caceda, R., & Nemeroff, C. B.
(2011).
Neurobiology and Genetics of Generalized Anxiety Disorder. PSYCHIATRIC ANNALS.
41(2), 113-123.
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Adkins, D. E., Aberg, K., McClay, J. L., Hettema, J. M., Kornstein, S. G., Bukszr, J., & van den Oord, E.
(2010).
A genomewide association study of citalopram response in major depressive disorder-a psychometric approach. Biological Psychiatry.
68(6), e25-e27.
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Maron, E., Hettema, J. M., & Shlik, J.
(2010).
Advances in molecular genetics of panic disorder. Molecular Psychiatry.
15(7), 681-701.
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Hettema, J. M.
(2010).
Generalized Anxiety Disorder Across the Lifespan: An Integrative Approach. Psychological Medicine.
40(4), 700-701.
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Middeldorp, C. M., Vink, J. M., Hettema, J. M., de Geus, E., Kendler, K. S., Willemsen, G., ... Chen, X.
(2010).
An association between Epac-1 gene variants and anxiety and depression in two independent samples. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
153B(1), 214-219.
-
Hettema, J. M.
(2010).
Genetics of Depression. FOCUS.
8(3), 316-322.
-
Hettema, J. M., An, S., van den Oord, E., Neale, M. C., Kendler, K. S., & Chen, X.
(2009).
Association study of CREB1 with Major Depressive Disorder and related phenotypes. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
150B(8), 1128-1132.
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Pham, X., Sun, C., Chen, X., van den Oord, E., Neale, M. C., Kendler, K. S., & Hettema, J. M.
(2009).
Association study between GABA receptor genes and anxiety spectrum disorders. 26(11), 998-1003.
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Chen, X., Chen, J., Williamson, V. S., An, S., Hettema, J. M., Aggen, S. H., Neale, M. C., & Kendler, K. S.
(2009).
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
150B(7), 926-933.
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Hettema, J. M., van den Oord, E., An, S., Kendler, K. S., & Chen, X.
(2009).
Follow-up association study of novel neuroticism gene MAMDC1. Psychiatric Genetics.
19(4), 213-214.
-
Kubarych, T. S., Aggen, S. H., Hettema, J. M., Kendler, K. S., & Neale, M. C.
(2008).
Assessment of generalized anxiety disorder diagnostic criteria in the National Comorbidity Survey and Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. PSYCHOLOGICAL ASSESSMENT.
20(3), 206-216.
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van den Oord, E., Kuo, P., Hartmann, A. M., Webb, B. T., Mller, H., Hettema, J. M., ... Rujescu, D.
(2008).
Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Archives of General Psychiatry.
65(9), 1062-1071.
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Hettema, J. M., An, S., Bukszar, J., van den Oord, E., Neale, M. C., Kendler, K. S., & Chen, X.
(2008).
Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biological Psychiatry.
64(4), 302-310.
-
Hettema, J. M., An, S. S., van den Oord, E., Neale, M. C., Kendler, K. S., & Chen, X.
(2008).
Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
147B(5), 661-666.
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Chen, X., Williamson, V. S., An, S., Hettema, J. M., Aggen, S. H., Neale, M. C., & Kendler, K. S.
(2008).
Cannabinoid receptor 1 gene association with nicotine dependence. Archives of General Psychiatry.
65(7), 816-824.
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van Grootheest, D. S., Boomsma, D. I., Hettema, J. M., & Kendler, K. S.
(2008).
Heritability of obsessive-compulsive symptom dimensions. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
147B(4), 473-478.
-
Hettema, J. M.
(2008).
What is the genetic relationship between anxiety and depression?. American Journal of Medical Genetics Part C: Seminars in Medical Genetics.
148C(2), 140-146.
-
Hettema, J. M., An, S., Neale, M. C., van den Oord, E., Kendler, K. S., & Chen, X.
(2008).
Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders. 18(2), 73-79.
-
Hettema, J. M.
(2008).
The nosologic relationship between generalized anxiety disorder and major depression. 25(4), 300-316.
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Hasnain, M., Vieweg, W., Hettema, J. M., Colton, D., Fernandez, A., & Pandurangi, A. K.
(2008).
The risk of overweight in children and adolescents with major mental illness. SOUTHERN MEDICAL JOURNAL.
101(4), 367-372.
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Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G., ... Flint, J.
(2008).
A whole genome association study of neuroticism using DNA pooling. Molecular Psychiatry.
13(3), 302-312.
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Kessler, R. C., Gruber, M., Hettema, J. M., Hwang, I., Sampson, N., & Yonkers, K. A.
(2008).
Co-morbid major depression and generalized anxiety disorders in the National Comorbidity Survey follow-up. 38(3), 365-374.
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Hettema, J. M., Annas, P., Neale, M. C., Fredrikson, M., & Kendler, K. S.
(2008).
The genetic covariation between fear conditioning and self-report fears. Biological Psychiatry.
63(6), 587-593.
-
Hettema, J. M., & Ross, D. E.
(2007).
A case of aripiprazole-related tardive akathisia and its treatment with ropinirole. Journal of Clinical Psychiatry.
68(11), 1814-1815.
-
Bienvenu, O. J., Hettema, J. M., Neale, M. C., Prescott, C. A., & Kendler, K. S.
(2007).
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. American Journal of Psychiatry.
164(11), 1714-1721.
-
Hettema, J. M., An, S. S., Neale, M. C., Bukszar, J., van den Oord, E., Kendler, K. S., & Chen, X.
(2006).
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism (vol 11, pg 752, 2006). Molecular Psychiatry.
11(8), 794-794.
-
Hettema, J. M., Kuhn, J. W., Prescott, C. A., & Kendler, K. S.
(2006).
The impact of generalized anxiety disorder and stressful life events on risk for major depressive episodes. Psychological Medicine.
36(6), 789-795.
-
Vieweg, W., Julius, D. A., Fernandez, A., Beatty-Brooks, M., Hettema, J. M., & Pandurangi, A. K.
(2006).
Posttraumatic stress disorder: clinical features, pathophysiology, and treatment. American Journal of Medicine.
119(5), 383-390.
-
Kubarych, T. S., Aggen, S. H., Hettema, J. M., Kendler, K. S., & Neale, M. C.
(2005).
Endorsement frequencies and factor structure of DSM-III-R and DSM-IV Generalized Anxiety Disorder symptoms in women: implications for future research, classification, clinical practice and comorbidity. International Journal of Methods in Psychiatric Research.
14(2), 69-81.
-
Hettema, J. M., Prescott, C. A., Myers, J. M., Neale, M. C., & Kendler, K. S.
(2005).
The structure of genetic and environmental risk factors for anxiety disorders in men and women. Archives of General Psychiatry.
62(2), 182-189.
-
Hettema, J. M., Prescott, C. A., & Kendler, K. S.
(2004).
Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism. American Journal of Psychiatry.
161(9), 1581-1587.
-
Hettema, J. M., Prescott, C. A., & Kendler, K. S.
(2003).
The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder. Psychological Medicine.
33(8), 1423-1432.
-
Kendler, K. S., Hettema, J. M., Butera, F., Gardner, C. O., & Prescott, C. A.
(2003).
Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Archives of General Psychiatry.
60(8), 789-796.
-
Hettema, J. M., Annas, P., Neale, M. C., Kendler, K. S., & Fredrikson, M.
(2003).
A twin study of the genetics of fear conditioning. Archives of General Psychiatry.
60(7), 702-708.
-
Hettema, J. M., Neale, M. C., & Kendler, K. S.
(2001).
A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry.
158(10), 1568-1578.
-
Hettema, J. M., Prescott, C. A., & Kendler, K. S.
(2001).
A population-based twin study of generalized anxiety disorder in men and women. JOURNAL OF NERVOUS AND MENTAL DISEASE.
189(7), 413-420.
-
Kendler, K. S., Bulik, C. M., Silberg, J., Hettema, J. M., Myers, J., & Prescott, C. A.
(2000).
Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Archives of General Psychiatry.
57(10), 953-959.
-
Hettema, J. M., Corey, L. A., & Kendler, K. S.
(1999).
A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins. Drug and Alcohol Dependence.
57(1), 69-78.
-
Lee, C. Y., Hettema, J. M., Cheng, C. H., Conover, C., & Gallagher, T. F.
(1996).
Circularly and elliptically polarized microwave ionization of Na Rydberg atoms. Journal of Physics B: Atomic, Molecular and Optical Physics.
29(15), 3401-3415.
-
Hettema, J. M., Walsh, D., & Kendler, K. S.
(1996).
Testing the effect of season of birth on familial risk for schizophrenia and related disorders. British Journal of Psychiatry.
168(2), 205-209.
-
Hettema, J. M., Neale, M. C., & Kendler, K. S.
(1995).
Physical similarity and the equal-environment assumption in twin studies of psychiatric disorders. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
25(4), 327-335.
-
Lisdahl, K. M., Tapert, S., Sher, K. J., Gonzalez, R., Nixon, S. J., Feldstein Ewing, S. W., ... ABCD Consortium.
(2021).
Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study. Drug and Alcohol Dependence.
227, 108946-108946.
-
chapter
-
Hettema, J. M.
(2015).
The Etiology of Fear and Anxiety. Anxiety Disorders.
(pp. 189-200).
Oxford University Press (OUP).
-
Perez, J. A., Otowa, T., Roberson-Nay, R., & Hettema, J. M.
(2013).
Genetics of Anxiety Disorders. Ressler, K. J. (Eds.),
Neurobiology of Mental Illness.
(pp. 537-546).
Oxford University Press (OUP).
-
Maron, E., Hettema, J. M., & Shlik, J.
(2008).
Chapter 5.6 The genetics of human anxiety disorders. Handbook of Behavioral Neuroscience.
Handbook of Anxiety and Fear.
(pp. 475-510).
Elsevier.
-
Hettema, J. M.
(2015).
The Etiology of Fear and Anxiety. Anxiety Disorders.
(pp. 189-200).
Oxford University Press (OUP).
-
conference paper
-
Ask, H., Eilertsen, E. M., Gustavson, K., McAdams, T., Torvik, F. A., Hettema, J. M., ... Ystrom, E.
(2019).
Intergenerational transmission of parental neuroticism to offspring neuroticism, anxiety, and depression. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
548-548.
-
Neale, M. C., Andrews, P. W., & Hettema, J. M.
(2008).
Maximum Likelihood Estimation of Genetic, Environmental and Phenotypic Factor Scores. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
640-640.
-
Hettema, J. M., An, S. S., Neale, M. C., Bukszar, J., van den Oord, E., Kendler, K. S., & Chen, X.
(2006).
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Molecular Psychiatry.
752-762.
-
Hettema, J. M., Neale, M. C., Myers, J. M., Prescott, C. A., & Kendler, K. S.
(2006).
A population-based twin study of the relationship between neuroticism and internalizing disorders. American Journal of Psychiatry.
857-864.
-
Hettema, J. M., An, S., Neale, M. C., Van den Oord, E. J., Kendler, K. S., & Chen, X.
(2006).
Genetic association study of the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders. Neuropsychopharmacology.
S167-S167.
-
Hettema, J. M., An, S., Neale, M. C., Prescott, C. A., van den Oord, E. J., Kendler, K. S., & Chen, X.
(2005).
Association between glutamic acid decarboxylase (GAD) genes and mood and anxiety disorders. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
11-11.
-
Bienvenu, O. J., Hettema, J. M., Neale, M. C., Prescott, C. A., & Kendler, K. S.
(2005).
Extraversion and neuroticism as indices of genetic and environmental risk for social phobia. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
10-10.
-
Hettema, J. M., Neale, M. C., Myers, J. M., Prescott, C. A., & Kendler, K. S.
(2004).
The shared genetics of trait neuroticism and mood and anxiety disorders. American Journal of Medical Genetics Part A.
66-66.
-
Hettema, J. M., Annas, P., Neale, M. C., Fredrikson, M., & Kendler, K. S.
(2002).
Fear conditioning and self-report fear ratings: Genetic and environmental sources of covariation. American Journal of Medical Genetics Part A.
837-837.
-
Hettema, J. M., Annas, P., Neale, M. C., Fredrikson, M., & Kendler, K. S.
(2001).
A twin study of the genetics of fear conditioning. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
455-455.
-
Hettema, J. M., Prescott, C. A., & Kendler, K. S.
(2000).
A population-based twin study of generalized anxiety disorder in men and women. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
407-408.
-
Ask, H., Eilertsen, E. M., Gustavson, K., McAdams, T., Torvik, F. A., Hettema, J. M., ... Ystrom, E.
(2019).
Intergenerational transmission of parental neuroticism to offspring neuroticism, anxiety, and depression. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
548-548.
-
institutional repository document
-
Purves, K. L., Coleman, J., Meier, S. M., Rayner, C., Davis, K., Cheesman, R., ... Eley, T. C.
(2017).
A Major Role for Common Genetic Variation in Anxiety Disorders
-
Purves, K. L., Coleman, J., Meier, S. M., Rayner, C., Davis, K., Cheesman, R., ... Eley, T. C.
(2017).
A Major Role for Common Genetic Variation in Anxiety Disorders
Research
principal investigator on
Teaching
teaching activities
- MSCI685 Directed Studies Instructor
- MSCI689 Sptp:intro Phys Exam&pati Comm Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NRSC485 Directed Studies Instructor
Background
education and training
- M.D., Virginia Commonwealth University - (Richmond, Virginia, United States) 1996
- Ph.D. in Physics, Yale University - (New Haven, Connecticut, United States) 1990
- M.Phil. in Physics, Yale University - (New Haven, Connecticut, United States) 1983
- B.S. in Applied Physics - Dean Honor List, Columbia University - (New York, New York, United States) 1980
Contact
first name
- John
has last name
- Hettema
Other
- hettema@tamu.edu