Tumor Suppression Through the cGAMP/STING Pathway
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abstract
Our immune system is essential in protecting us against cancer. Manipulation of the host immune response is an attractive approach in cancer therapy. Interferons are important molecules in the immune system mediating antitumor and antiviral responses. However, interferons are not produced in our body under normal conditions. Bacteria or viruses can stimulate the production of interferons after they infect the host. It has been shown that the cGAMP/STING pathway activates the production of interferons. Bacterial or viral DNA can induce the activation of the cGAMP/STING pathway through the host enzyme called cGAS, which is a microbial DNA sensor in the immune system. cGAS catalyzes the synthes... Read More Our immune system is essential in protecting us against cancer. Manipulation of the host immune response is an attractive approach in cancer therapy. Interferons are important molecules in the immune system mediating antitumor and antiviral responses. However, interferons are not produced in our body under normal conditions. Bacteria or viruses can stimulate the production of interferons after they infect the host. It has been shown that the cGAMP/STING pathway activates the production of interferons. Bacterial or viral DNA can induce the activation of the cGAMP/STING pathway through the host enzyme called cGAS, which is a microbial DNA sensor in the immune system. cGAS catalyzes the synthesis of small drug like molecule called cGAMP that binds to the protein molecule called STING and triggers a cascade of signals that eventually lead to the induction of interferons.........
