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DeMorrow, Sharon Associate Professor


My research broadly focuses on the factors controlling hyperplastic and neoplastic cholangiocyte proliferation. Cholangiocytes are the epithelial cells that line in the intra- and extra-hepatic bile ducts and that are responsible for the modification of ductal bile.; These cells are the target of cholestatic liver diseases such as primary biliary cirrhosis and primary sclerosing cholangitis, and are characterized by cholangiocyte proliferation and/or loss. This class of liver disease represents the first major indicator for liver transplantation in children and the third major indicator in adults. The neoplastic transformation of cholangiocytes into the malignant counterpart gives rise to cholangiocarcinoma, which has very few effective treatment options and poor prognosis. Thus, factors that affect the hyperplastic and neoplastic cholangiocyte proliferation may lead to novel treatment paradigms.

HR job title

  • Associate Professor