Understanding the role of MHCI compatibility in equine allogeneic mesenchymal stem cells Grant uri icon

abstract

  • Regenerative medicine, such as autologous stem cells, hasbecome popular to treat a variety of orthopedic conditions. Most commonly, autologous (from the recipient) stem cells are utilized because use of allogeneic (from a donor) stem cells have been shown to cause inflammation and injection site reactions. This is despite the common thought that stem cells are immune privileged, meaning that the immune system will not recognize them. The purpose of this study is to evaluate differences between donors and recipients of stem cells in an attempt to narrow down the cause of the apparent immune response. This will be done by matching horses based on genetic markers and comparing the response after stem cell injection to horses that are genetically mis-matched. This matching and mis-matching will be based on MHC (major histocompatibility complex) compatibility, which is the major determinate of graft rejection in organ transplantation. Shedding light on this issue could have the potential to translate to human medicine and eventually lead to standardization of allogeneic stem cell usage.

date/time interval

  • 2018 - 2020