HR job title
- Associate Professor
- Contact Info
- ORCiD
- 0000-0003-1217-9813
Subashchandrabose, Sargurunathan Assistant Professor
Positions
- Assistant Professor, Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences
I have a long-standing interest in elucidating the molecular and cellular effectors at the host-pathogen interface to identify therapeutic targets against infectious diseases.
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- Research
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- Contact
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Overview
Publications
selected publications
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academic article
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Robinson, C. K., Saenkham-Huntsinger, P., Hanson, B. S., Adams, L. G., & Subashchandrabose, S.
(2022).
Vaginal Inoculation of Uropathogenic Escherichia coli during Estrus Leads to Genital and Renal Colonization. Infection and Immunity.
90(4), e0053221-e00521.
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Hyre, A., Casanova-Hampton, K., & Subashchandrabose, S.
(2021).
Copper Homeostatic Mechanisms and Their Role in the Virulence of Escherichia coli and Salmonella enterica. 9(2), eESP00142020.
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Casna, B. R., Simmerson, S. M., & Subashchandrabose, S.
(2021).
Feasibility study evaluating a veterinary point‐of‐care urine culture system for diagnosing septic peritonitis. Journal of Veterinary Emergency and Critical Care.
31(5), 595-600.
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Saenkham, P., Jennings-Gee, J., Hanson, B., Kock, N. D., Adams, L. G., & Subashchandrabose, S.
(2020).
Hyperglucosuria induced by dapagliflozin augments bacterial colonization in the murine urinary tract. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics.
22(9), 1548-1555.
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Saenkham, P., Ritter, M., Donati, G. L., & Subashchandrabose, S.
(2020).
Copper primes adaptation of uropathogenic Escherichia coli to superoxide stress by activating superoxide dismutases. PLOS Pathogens.
16(8), e1008856-e1008856.
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Nagpal, R., Wang, S., Ahmadi, S., Hayes, J., Gagliano, J., Subashchandrabose, S., ... Yadav, H.
(2018).
Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome. Scientific Reports.
8(1), 12649.
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Subashchandrabose, S., Pereira-Filho, E. R., & Donati, G. L.
(2017).
Trace element analysis of urine by ICP-MS/MS to identify urinary tract infection. Journal of Analytical Atomic Spectrometry.
32(8), 1590-1594.
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Subashchandrabose, S., & Mobley, H.
(2015).
Virulence and Fitness Determinants of Uropathogenic Escherichia coli. Microbiology spectrum.
3(4), 235-261.
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Subashchandrabose, S., & Mobley, H.
(2015).
Back to the metal age: battle for metals at the host-pathogen interface during urinary tract infection. Metallomics.
7(6), 935-942.
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Brumbaugh, A. R., Smith, S. N., Subashchandrabose, S., Himpsl, S. D., Hazen, T. H., Rasko, D. A., & Mobley, H.
(2015).
Blocking yersiniabactin import attenuates extraintestinal pathogenic Escherichia coli in cystitis and pyelonephritis and represents a novel target to prevent urinary tract infection. 83(4), 1443-1450.
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Subashchandrabose, S., Hazen, T. H., Brumbaugh, A. R., Himpsl, S. D., Smith, S. N., Ernst, R. D., Rasko, D. A., & Mobley, H.
(2014).
Host-specific induction of Escherichia coli fitness genes during human urinary tract infection. Proceedings of the National Academy of Sciences of the United States of America.
111(51), 18327-18332.
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Subashchandrabose, S., Hazen, T. H., Rasko, D. A., & Mobley, H.
(2013).
Draft genome sequences of five recent human uropathogenic Escherichia coli isolates. 69(1), 66-70.
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Subashchandrabose, S., Leveque, R. M., Kirkwood, R. N., Kiupel, M., & Mulks, M. H.
(2013).
The RNA chaperone Hfq promotes fitness of Actinobacillus pleuropneumoniae during porcine pleuropneumonia. Infection and Immunity.
81(8), 2952-2961.
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Subashchandrabose, S., Smith, S. N., Spurbeck, R. R., Kole, M. M., & Mobley, H.
(2013).
Genome-wide detection of fitness genes in uropathogenic Escherichia coli during systemic infection. PLOS Pathogens.
9(12), e1003788-e1003788.
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Subashchandrabose, S., LeVeque, R. M., Wagner, T. K., Kirkwood, R. N., Kiupel, M., & Mulks, M. H.
(2009).
Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infection and Immunity.
77(11), 4925-4933.
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Casanova-Hampton, K., Carey, A., Kassam, S., Garner, A., Donati, G. L., Thangamani, S., & Subashchandrabose, S.
A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress. Metallomics.
13(9), mfab052.
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Subashchandrabose, S., Smith, S., DeOrnellas, V., Crepin, S., Kole, M., Zahdeh, C., & Mobley, H.
Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection. mSphere.
1(1), 10.1128/msphere.00013-10.1128/msphere.00015.
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George, I., Kalairaj, M. S., Zimmern, P. E., Ware, T. H., & Subashchandrabose, S.
Competitive fitness of asymptomatic bacteriuria E. coli strain 83972 against uropathogens in human urine. Infection and Immunity.
92(6), e0017324-e00124.
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Hyre, A. N., Kavanagh, K., Kock, N. D., Donati, G. L., & Subashchandrabose, S.
Copper Is a Host Effector Mobilized to Urine during Urinary Tract Infection To Impair Bacterial Colonization. Infection and Immunity.
85(3), 10.1128/iai.01041-10.1128/iai.01016.
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Saenkham-Huntsinger, P., Hyre, A. N., Hanson, B. S., Donati, G. L., Adams, L. G., Ryan, C., ... Subashchandrabose, S.
Copper Resistance Promotes Fitness of Methicillin-Resistant Staphylococcus aureus during Urinary Tract Infection. mBio.
12(5), e0203821-10.1128/mbio.02021.
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Packiriswamy, N., Gandy, J., Smith, S. N., Mobley, H., Sordillo, L. M., & Subashchandrabose, S.
Distinct Signature of Oxylipid Mediators of Inflammation during Infection and Asymptomatic Colonization by E. coli in the Urinary Bladder. Mediators of Inflammation.
2017(1), 4207928-16.
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Subashchandrabose, S., & Mobley, H.
Gentamicin Protection Assay to Determine Bacterial Survival within Macrophages. Bio-protocol.
4(18),
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Hanson, B. S., Hailemariam, A., Yang, Y., Mohamed, F., Donati, G. L., Baker, D., ... Subashchandrabose, S.
Identification of a copper-responsive small molecule inhibitor of uropathogenic Escherichia coli. Journal of Bacteriology.
206(7), e0011224-e00124.
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Motayagheni, N., Subashchandrabose, S., Gutierrez-Aceves, J., & Mirzazadeh, M.
MP10-07 EVALUATION OF BACTERIAL BIOFILMS ON RENAL CALCULI. Investigative urology.
199(4), e118.
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Sintsova*, A., Pirani, A., Subashchandrabose, S., Snitkin, E., & Mobley, H.
MP71-01GENETICALLY DIVERSE UROPATHOGENIC ESCHERICHIA COLI ADOPT A COMMON TRANSCRIPTIONAL PROGRAM IN PATIENTS WITH URINARY TRACT INFECTIONS. Investigative urology.
201(Supplement 4),
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Sintsova, A., Smith, S., Subashchandrabose, S., & Mobley, H. L.
Role of Ethanolamine Utilization Genes in Host Colonization during Urinary Tract Infection. Infection and Immunity.
86(3), 10.1128/iai.00542-10.1128/iai.00517.
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Saenkham-Huntsinger, P., Ritter, M., Donati, G. L., Mitchell, A. M., & Subashchandrabose, S.
The inner membrane protein YhiM links copper and CpxAR envelope stress responses in uropathogenic E. coli. mBio.
15(4), e0352223-e03523.
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Robinson, C. K., Saenkham-Huntsinger, P., Hanson, B. S., Adams, L. G., & Subashchandrabose, S.
(2022).
Vaginal Inoculation of Uropathogenic Escherichia coli during Estrus Leads to Genital and Renal Colonization. Infection and Immunity.
90(4), e0053221-e00521.
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chapter
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Subashchandrabose, S., & Mobley, H.
Virulence and Fitness Determinants of Uropathogenic Escherichia coli. Urinary Tract Infections.
(pp. 235-261).
American Society for Microbiology.
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Subashchandrabose, S., & Mobley, H.
Virulence and Fitness Determinants of Uropathogenic Escherichia coli. Urinary Tract Infections.
(pp. 235-261).
American Society for Microbiology.
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conference paper
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Sintsova, A., Frick-Cheng, A. E., Smith, S., Pirani, A., Subashchandrabose, S., Snitkin, E. S., & Mobley, H.
(2019).
Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with UTIs. eLife.
E1046-E1046.
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Motayagheni, N., Subashchandrabose, S., Gutierrez-Aceves, J., & Mirzazadeh, M.
(2018).
EVALUATION OF BACTERIAL BIOFILMS ON RENAL CALCULI. Journal of Urology.
E118-E118.
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Motayagheni, N., Hyre, A., Mirzazadeh, M., Subashchandrabose, S., & Atala, A.
(2017).
NOVEL APPLICATIONS OF CALCIUM CHANNEL BLOCKERS: A NEW INSIGHT TO CARDIAC DRUGS. Cardiology: international journal of cardiovascular medicine, surgery and pathology.
43-43.
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Subashchandrabose, S., Brumbaugh, A., Himpsl, S., Rasko, D., & Mobley, H.
TRANSCRIPTOME OF UROPATHOGENIC ESCHERICHIA COLI DURING HUMAN URINARY TRACT INFECTIONS. Journal of Urology.
E470-E471.
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Sintsova, A., Frick-Cheng, A. E., Smith, S., Pirani, A., Subashchandrabose, S., Snitkin, E. S., & Mobley, H.
(2019).
Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with UTIs. eLife.
E1046-E1046.
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dataset
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Subashchandrabose, S., Smith, S. N., Spurbeck, R. R., Kole, M. M., & Mobley, H.
Bacterial strains and plasmids
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Subashchandrabose, S., Smith, S. N., Spurbeck, R. R., Kole, M. M., & Mobley, H.
Genome-Wide Detection of Fitness Genes in Uropathogenic Escherichia coli during Systemic Infection
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Saenkham, P., Ritter, M., Donati, G. L., & Subashchandrabose, S.
Strains and plasmids used in this study
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Subashchandrabose, S., Smith, S. N., Spurbeck, R. R., Kole, M. M., & Mobley, H.
Transposon mutants with reduced in vivo fitness
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Subashchandrabose, S., Smith, S. N., Spurbeck, R. R., Kole, M. M., & Mobley, H.
Bacterial strains and plasmids
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institutional repository document
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Kalairaj, M. S., George, I., George, S. M., Farfn, S. E., Lee, Y. J., Rivera-Tarazona, L. K., ... Ware, T. H.
Controlled release of microorganisms from engineered living materials
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Kalairaj, M. S., George, I., George, S. M., Farfn, S. E., Lee, Y. J., Rivera-Tarazona, L. K., ... Ware, T. H.
Controlled release of microorganisms from engineered living materials
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webpage
Research
principal investigator on
- Copper is a Host Effector in Protection Against Urinary Tract Infection awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2022
- Harnessing Copper to Impede Uropathogen Colonization awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2021
Teaching
teaching activities
- BIMS289 Sptp: Fundament Personal Hlth Instructor
- BIMS491 Hnr-research Instructor
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT685 Directed Studies Instructor
- GENE491 Hnr-research Instructor
- GENE691 Research Instructor
- VTMI636 Bacteria In Health & Disease Instructor
- VTMI681 Seminar Instructor
- VTMI685 Directed Studies Instructor
- VTMI689 Sptp: Bacteria In Hlth & Dis Instructor
- VTMI691 Research Instructor
- VTPB285 Directed Studies Instructor
- VTPB405 Biomedical Microbiology Instructor
- VTPB485 Directed Studies Instructor
Background
education and training
- Ph.D. in Bacterial Pathogenesis, Michigan State University - (East Lansing, Michigan, United States) 2011
- B.V.S. in Veterinary Medicine, Tamil Nadu Veterinary and Animal Sciences University - (Chennai, Tamil Nadu, India) 2005
- University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States) , Postdoctoral Training 2015
Contact
first name
- Sargurunathan
has last name
- Subashchandrabose
mailing address
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Texas A&M University
Vet Med Pathobiology
4467 TAMU
College Station, TX 77843-4467
USA
Other
- sarguru@tamu.edu