Hemmy, Laura Sue (2006-12). Educational attainment and rate of cognitive decline in Alzheimer's disease. Doctoral Dissertation. Thesis uri icon

abstract

  • Alzheimer's disease (AD) progression and hypotheses of the cognitive reserve theory were investigated by testing for a relation between educational attainment and rate of decline in patients with Mild Cognitive Impairment, possible AD, probable AD, and other progressive neurodegenerative dementias. Patient data (n = 726) were acquired from a clinical database at the Minneapolis VAMC GRECC Memory Loss Clinic. Analyses using mixed effect regression models found education was significantly related to an accelerated rate of decline in global cognition (MMSE: -0.022, SE = 0.007, p = .003) and a steeper linear rate of decline in functional ability (Cognitive Performance Test: -0.034, SE = 0.011, p = .005). Cox proportional hazard models found little evidence to support an association between educational attainment and relative mortality risk. These results are consistent with previous findings and predictions of the cognitive reserve theory.
  • Alzheimer's disease (AD) progression and hypotheses of the cognitive reserve
    theory were investigated by testing for a relation between educational attainment and
    rate of decline in patients with Mild Cognitive Impairment, possible AD, probable AD,
    and other progressive neurodegenerative dementias. Patient data (n = 726) were
    acquired from a clinical database at the Minneapolis VAMC GRECC Memory Loss
    Clinic. Analyses using mixed effect regression models found education was
    significantly related to an accelerated rate of decline in global cognition (MMSE:
    -0.022, SE = 0.007, p = .003) and a steeper linear rate of decline in functional ability
    (Cognitive Performance Test: -0.034, SE = 0.011, p = .005). Cox proportional hazard
    models found little evidence to support an association between educational attainment
    and relative mortality risk. These results are consistent with previous findings and
    predictions of the cognitive reserve theory.

publication date

  • December 2006