Choi, Jung Woo (2009-08). Identification of Signatures of Selection in Bos Taurus Beef and Dairy Cattle Using Genome-wide SNP Genotypes. Doctoral Dissertation. Thesis uri icon

abstract

  • The objectives of this study were to identify signatures of selection in Bos taurus beef and dairy cattle populations and to annotate regions of selection with gene, function and QTL information. Differences in minor allele frequencies, population-average FST, population-specific FST, and integrated extended haplotype homozygosity scores were applied to a subset of the bovine HapMap data to characterize signatures of selection in 7 Bos taurus beef and 5 Bos taurus dairy cattle populations. Numerous single nucleotide polymorphisms (SNP) exhibited evidence of selection across the genome and regions of BTA2 and BTA14 that are considered to be under positive selection in beef and dairy cattle, respectively, were highlighted. The current density of SNP limited our ability to annotate regions putatively under selection because most SNP in the assay were intergenic. This is likely because of the betweenbreed SNP discovery method that was used, which typically identifies SNP with higher allele frequencies.
  • The objectives of this study were to identify signatures of selection in Bos taurus
    beef and dairy cattle populations and to annotate regions of selection with gene, function
    and QTL information. Differences in minor allele frequencies, population-average FST,
    population-specific FST, and integrated extended haplotype homozygosity scores were
    applied to a subset of the bovine HapMap data to characterize signatures of selection in 7
    Bos taurus beef and 5 Bos taurus dairy cattle populations.
    Numerous single nucleotide polymorphisms (SNP) exhibited evidence of
    selection across the genome and regions of BTA2 and BTA14 that are considered to be
    under positive selection in beef and dairy cattle, respectively, were highlighted. The
    current density of SNP limited our ability to annotate regions putatively under selection
    because most SNP in the assay were intergenic. This is likely because of the betweenbreed
    SNP discovery method that was used, which typically identifies SNP with higher
    allele frequencies.

publication date

  • August 2009