Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic ganglia. Academic Article

abstract

• The sucrose-gap recording technique was used to study mammalian parasympathetic ganglionic transmission. Both a fast nicotinic depolarization potential and a slow muscarinic hyperpolarizing potential were recorded in vesical pelvic ganglia (VPG). A long afterhyperpolarization caused by an electrical response of through-fibers was also recorded. However, a slow excitatory postsynaptic potential (S-EPSP) was not readily observed and may be masked by the long afterhyperpolarization. In addition, the slow inhibitory postsynaptic potential (S-IPSP) of the VPG was due to a direct effect of acetylcholine (ACh). Thus, sucrose-gap recordings of VPG potentials are similar to those obtained in sympathetic ganglia, but the mechanism for transmission of the S-IPSP may be different in the respective ganglia.

authors

• Griffith, William

published proceedings

• Brain Res

author list (cited authors)

• Griffith, W. H., Gallagher, J. P., & Shinnick-Gallagher, P.

citation count

• 18

complete list of authors

• Griffith, WH||Gallagher, JP||Shinnick-Gallagher, P

publication date

• March 1981

publisher

• Elsevier  Publisher

published in

• BRAIN RESEARCH  Journal

keywords

• Acetylcholine
• Animals
• Cats
• Evoked Potentials
• Ganglia, Parasympathetic
• Muscle, Smooth
• Nerve Fibers
• Receptors, Muscarinic
• Receptors, Nicotinic
• Synapses
• Synaptic Transmission
• Urinary Bladder

PubMed Central ID

• 6261869

Digital Object Identifier (DOI)

• 10.1016/0006-8993(81)90168-2

start page

• 446

end page

• 451

volume

• 209

issue

• 2

URL

• http://dx.doi.org/10.1016/0006-8993(81)90168-2