Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic ganglia. Academic Article uri icon


  • The sucrose-gap recording technique was used to study mammalian parasympathetic ganglionic transmission. Both a fast nicotinic depolarization potential and a slow muscarinic hyperpolarizing potential were recorded in vesical pelvic ganglia (VPG). A long afterhyperpolarization caused by an electrical response of through-fibers was also recorded. However, a slow excitatory postsynaptic potential (S-EPSP) was not readily observed and may be masked by the long afterhyperpolarization. In addition, the slow inhibitory postsynaptic potential (S-IPSP) of the VPG was due to a direct effect of acetylcholine (ACh). Thus, sucrose-gap recordings of VPG potentials are similar to those obtained in sympathetic ganglia, but the mechanism for transmission of the S-IPSP may be different in the respective ganglia.

published proceedings

  • Brain Res

author list (cited authors)

  • Griffith, W. H., Gallagher, J. P., & Shinnick-Gallagher, P.

citation count

  • 18

complete list of authors

  • Griffith, WH||Gallagher, JP||Shinnick-Gallagher, P

publication date

  • March 1981