Histamine-induced early afterdepolarizations and triggered activity in guinea-pig papillary muscles Academic Article uri icon


  • The effects of histamine on the transmembrane action potentials were studied with computerized standard microelectrode technique in guinea-pig papillary muscles. Experiments offered evidence that histamine (6.0mol / L) caused a significant diminution in action potential duration at 50% repolarization (APD50) and 90% repolarization (APD90) (data from no abnormal automaticity and oscillatory potential cells). Histamine could induce early afterdepolarizations (BAD, 57%), oscillatory potentials and triggered activity. HAD frequently occurred at low stimulation frequencies (0.2- 1.0Hz) with prolongation of the action potential duration. EAD-in-duced triggered activity exhibited fast spontaneous action potential (14%). The results suggested that histamine-induced EAD and triggered activity might relate to the autorhythmic tachyarrhythmias seen in cardiac anaphylaxis, etc.

published proceedings

  • Chinese Journal of Applied Physiology

author list (cited authors)

  • Xin, W., Weiqiu, H., & Zhiming, Y.

complete list of authors

  • Xin, W||Weiqiu, H||Zhiming, Y

publication date

  • January 1, 1993 11:11 AM