Role of the central alpha-receptors in the modulation of carotid sinus reflex of rats Academic Article uri icon

abstract

  • To investigate the effects of the central alpha-receptors on the carotid sinus reflex, phenoxybenzamine (PBZ, 2 micrograms/20 microliters) or yohimbine (Y, 2 micrograms/20 microliters) was injected into the lateral cerebral ventricle (LCV) and intracarotid sinus pressure (ISP)-mean arterial pressure (MAP) relationship curve was constructed and fitted by a Logistic function. The results were as follows: (1) After injection of PBZ into LCV, the ISP-MAP relationship curve shifted upward at a higher ISP level with decreased peak slope and MAP range while the ISP-slope curve shifted downward. (2) After injection of Y into LCV, the ISP-MAP relationship curve shifted upward at a higher ISP level with decreased peak slope and MAP range and increased threshold. The ISP-slope curve shifted downward significantly at 10.64, 15.96 kPa. The peak slope and MAP range of Y group decreased significantly as compared with that of the PBZ group. These results indicated that after blockage of central alpha-receptors the sensitivity of the sinus reflex decreased significantly, and the blockage action of alpha 2-receptor is greater than that of alpha 1-receptor.

published proceedings

  • Sheng li xue bao:[Acta physiologica Sinica]

author list (cited authors)

  • Huang, W. Q., Xu, H. D., Wu, X., Xu, B., & Yu, Z. M.

complete list of authors

  • Huang, WQ||Xu, HD||Wu, X||Xu, B||Yu, ZM

publication date

  • January 1, 1992 11:11 AM