RNA Higher-Order Structures Within the Coronavirus 5 and 3 Untranslated Regions and Their Roles in Viral Replication Chapter uri icon

abstract

  • The 5 and 3 untranslated regions (UTRs) of all coronaviruses contain RNA higher-order structures which play essential roles in viral transcription and replication. In this chapter we present our current knowledge of how those cis-acting elements were defined and their functional roles in viral transcription and replication. Cellular proteins which have been shown binding to those cis-acting elements and potentially support the RNA discontinuous synthesis model are also discussed. A conserved RNA structure model for the 5 and 3 UTRs of group 2 coronaviruses is presented with the known cellular protein binding sites.

author list (cited authors)

  • Liu, P., & Leibowitz, J.

citation count

  • 8

complete list of authors

  • Liu, Pinghua||Leibowitz, Julian

editor list (cited editors)

  • Lal, S. K.

Book Title

  • Molecular Biology of the SARS-Coronavirus

publication date

  • January 2010