Bortezomib-induced thrombocytopenia is transient in patients with multiple myeloma Academic Article uri icon


  • A new constrained optimization approach to the coarsening of 3D reservoir models for flow simulation has been developed. The optimization preserves a statistical measure of the heterogeneity of a fine-scale model. Constraints arise from the reservoir fluids, well locations, pay/nonpay juxtaposition, and large-scale reservoir structure and stratigraphy. The approach has been validated for several oil and gas projects in that flow simulation through the coarsened model was shown to provide an excellent approximation to high-resolution calculations performed in the original model.

author list (cited authors)

  • King, A.

citation count

  • 0

publication date

  • February 2006