Oxygen-18 studies on the conversion of proline to collagen hydroxyproline. Academic Article

abstract

• Oxygen-18 was used to study the synthesis of collagen hydroxyproline in vivo by chick embryos. The oxygen incorporated into the hydroxyl group was found to originate from atmospheric oxygen rather than water, and therefore the results indicate that an oxygenase mechanism is involved in the conversion of proline to hydroxyproline. Since earlier studies have shown that free proline is not hydroxylated directly, it appears that the oxygen acceptor in this case is an activated form of proline. 1963.

authors

• Prockop, Darwin

published proceedings

• Arch Biochem Biophys

altmetric score

• 3

author list (cited authors)

• PROCKOP, D., KAPLAN, A., & UDENFRIEND, S.

citation count

• 73

complete list of authors

• PROCKOP, D||KAPLAN, A||UDENFRIEND, S

publication date

• January 1963

publisher

• Elsevier  Publisher

published in

• Archives of Biochemistry and Biophysics  Journal

keywords

• Collagen
• EMBRYO
• Embryo, Mammalian
• Embryo, Nonmammalian
• Hydroxyproline
• Oxygen
• Proline

Digital Object Identifier (DOI)

• 10.1016/0003-9861(63)90509-5

start page

• 499

end page

• 503

volume

• 101

issue

• 3

URL

• http://dx.doi.org/10.1016/0003-9861(63)90509-5