Regeneration after nerve transection: effect of inhibition of collagen synthesis. Academic Article

abstract

• Dense collagen scar forms at the cut ends of transected nerves, and impedes nerve regeneration. To minimize scarring, we treated rats with the proline analog, cis-hydroxyproline, from day 4 to 21 after sciatic nerve transection and reanastomosis. Twenty-eight days after surgery, there was 47% less collagen in the distal nerve stump of treated rats than of controls. Seventy days after surgery, posterior tibial nerve content of the myelin lipids, sulfatide, and unesterified cholesterol, was 40% higher in treated rats than in controls. 1974.

authors

• Prockop, Darwin

published proceedings

• Exp Neurol

altmetric score

• 6

author list (cited authors)

• Pleasure, D., Bora, F. W., Lane, J., & Prockop, D.

citation count

• 41

complete list of authors

• Pleasure, D||Bora, FW||Lane, J||Prockop, D

publisher

• Elsevier  Publisher

published in

• Experimental Neurology  Journal

keywords

• Amino Acids
• Animals
• Cholesterol
• Collagen
• Lipid Metabolism
• Male
• Myelin Sheath
• Nerve Regeneration
• Peripheral Nerves
• Postoperative Complications
• Proline
• Rats
• Rats, Inbred Strains
• Sulfoglycosphingolipids

Digital Object Identifier (DOI)

• 10.1016/0014-4886(74)90101-0

start page

• 72

end page

• 78

volume

• 45

issue

• 1

URL

• http://dx.doi.org/10.1016/0014-4886(74)90101-0