Reduction in the urinary aflatoxin M1 biomarker as an early indicator of the efficacy of dietary interventions to reduce exposure to aflatoxins.
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Aflatoxin B1 is a persistent public health issue in Ghana. Assessment of AFB1 intervention efficacy is currently dependent on long-term biomarkers. This study was designed to determine whether daily AFM1 biomarker levels could be utilized as an early detection method for intervention efficacy. Participants were treated with a refined calcium montmorillonite clay (UPSN) or a placebo (calcium carbonate) in a crossover study. Urine samples were assessed for AFM1 levels daily. UPSN treatment reduced AFM1 biomarkers by 55% compared to the placebo. This is the first study to show that daily urinary AFM1 levels can be used as a biomarker of internal aflatoxin B1 exposure in short-term intervention trials to determine efficacy.
author list (cited authors)
Mitchell, N. J., Kumi, J., Johnson, N. M., Dotse, E., Marroquin-Cardona, A., Wang, J., ... Phillips, T. D.
complete list of authors
Mitchell, Nicole J||Kumi, Justice||Johnson, Natalie M||Dotse, Eunice||Marroquin-Cardona, Alicia||Wang, Jia-Sheng||Jolly, Pauline E||Ankrah, Nii-Ayi||Phillips, Timothy D