NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis. Academic Article uri icon


  • To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups that received 3.0 g NS day(-1) (high dose, HD), 1.5 g NS day(-1) (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Gender-stratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose-time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p < 0.001) in the HD group (male = 113.65 +/- 28.00 microg l(-1); female = 116.40 +/- 24.26 microg l(-1)) compared with the PL group (male = 83.55 +/- 39.90 microg l(-1); female = 90.47 +/- 25.68 microg l(-1)) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans.

published proceedings

  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess

author list (cited authors)

  • Afriyie-Gyawu, E., Wang, Z., Ankrah, N., Xu, L., Johnson, N. M., Tang, L., ... Phillips, T. D.

citation count

  • 36

complete list of authors

  • Afriyie-Gyawu, E||Wang, Z||Ankrah, N-A||Xu, L||Johnson, NM||Tang, L||Guan, H||Huebner, HJ||Jolly, PE||Ellis, WO||Taylor, R||Brattin, B||Ofori-Adjei, D||Williams, JH||Wang, J-S||Phillips, TD

publication date

  • July 2008