Seminars in medicine of the Beth Israel Hospital, Boston. Mutations in collagen genes as a cause of connective-tissue diseases. Academic Article uri icon

abstract

  • FOR more than 10 years, my colleagues and I have been testing the relatively simple hypothesis that the degeneration of connective tissue characteristic of many diseases is the result of genetic defects in the collagens that provide most of the strength of the normal tissues. We and others first examined this hypothesis in relatively rare genetic diseases in which bone, cartilage, and other tissues can be so fragile as to be life-threatening early in life. More recently, we have tried to see whether the same hypothesis applies to more common diseases, such as osteoporosis, osteoarthritis, and aortic aneurysms. Structure, Function,... 1992, Massachusetts Medical Society. All rights reserved.

published proceedings

  • N Engl J Med

altmetric score

  • 3

author list (cited authors)

  • Prockop, D. J.

citation count

  • 107

complete list of authors

  • Prockop, DJ

publication date

  • February 1992