A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline.
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abstract
A model for the triple-helical conformation of (Pro-Hyp-Gly)10 has been developed which can account for the recent observation that hydroxyproline contributes to the stability of the triple helix in aqueous solution. Previous structures proposed for (Pro-Gly-Pro)n and collagen were modified to allow the formation of a new inter-chain hydrogen bond between the hydroxyl group of hydroxyproline and the carbonyl group of glycine in an adjacent chain. To create this hydrogen bond, the new model postulates a cis peptide bond between glycine and proline. 1973.