Osteogenesis imperfecta. A model for genetic causes of osteoporosis and perhaps several other common diseases of connective tissue. Academic Article uri icon


  • Recent studies of patients with the heritable disorder, osteogenesis imperfecta (OI), have demonstrated that a number of OI patients have mutations in one of the two structural genes that code for type I procollagen (1-3). In addition, data we have obtained on one family illustrate how gene analysis can define the genetic component in one form of osteoporosis.

published proceedings

  • Arthritis Rheum

altmetric score

  • 3

author list (cited authors)

  • Prockop, D. J.

citation count

  • 25

complete list of authors

  • Prockop, DJ

publication date

  • January 1988