Assignment of the human collagen alpha 1 (XIII) chain gene (COL13A1) to the q22 region of chromosome 10. Academic Article uri icon

abstract

  • Type XIII collagen is a recently described collagen that resembles in structure the short-chain collagens of types IX, X, and XII. Unlike any other collagen, the type XIII is found in several different forms generated through alternative splicing. A 2.0-kb genomic fragment from the human alpha 1 (XIII) collagen gene was isolated and shown by DNA sequencing to contain exon 12 as counted from the 3' end. This fragment was used as a probe to localize the gene. The gene (COL13A1) was assigned to chromosome 10 by hybridization of the probe to DNA isolated from a panel of human-mouse somatic cell hybrids containing different human chromosomes. Furthermore, the gene was mapped to the q22 region by in situ hybridization to metaphase chromosomes.

published proceedings

  • Genomics

altmetric score

  • 3

author list (cited authors)

  • Shows, T. B., Tikka, L., Byers, M. G., Eddy, R. L., Haley, L. L., Henry, W. M., Prockop, D. J., & Tryggvason, K.

citation count

  • 14

complete list of authors

  • Shows, TB||Tikka, L||Byers, MG||Eddy, RL||Haley, LL||Henry, WM||Prockop, DJ||Tryggvason, K

publication date

  • July 1989