beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster. Academic Article uri icon

abstract

  • beta-Aminopropionitrile (beta APN), an agent that prevents collagen accumulation in tissues, was evaluated for its ability to prevent excess collagen formation in bleomycin-induced pulmonary fibrosis in the hamster. Two groups of animals received a single endotracheal dose of bleomycin; one of these was injected with beta APN twice daily for 30 days. A third group received endotracheal saline and a fourth group received saline and beta APN. After 30 days, we measured pressure-volume curves of saline-filled lungs, collagen content, and degree of fibrosis. Endotracheal bleomycin increased collagen content, decreased lung volume, and produced fibrosis and a mortality rate of 51%. The administration of beta APN to bleomycin-treated animals prevented excess collagen accumulation and diminished total protein, reversed volume diminution, produced less fibrosis, and improved the mortality rate to 24%; beta APN alone had no effect on lung mechanics or collagen content. The biochemical, functional, and structural features of bleomycin-induced lung fibrosis are amenable to control with beta APN.

published proceedings

  • Am Rev Respir Dis

author list (cited authors)

  • Riley, D. J., Kerr, J. S., Berg, R. A., Ianni, B. D., Pietra, G. G., Edelman, N. H., & Prockop, D. J.

citation count

  • 0

complete list of authors

  • Riley, DJ||Kerr, JS||Berg, RA||Ianni, BD||Pietra, GG||Edelman, NH||Prockop, DJ

publication date

  • January 1982