Hydroxylation of proline and the intracellular accumulation of a polypeptide precursor of collagen. Academic Article uri icon

abstract

  • Autoradiographs of embryonic cartilage indicated that labeled protein accumnulated intracellularly when the tissue was incubated with tritiated proline, and when the hydroxylation of proline was inhibited by anaerobic conditions or by a chelator for ferrous iron. The labeled protein apparently corresponds to protocollagen. the polypeptide precursor of collagen which serves as a substrate for the enzymatic synthesis of hydroxyproline.

published proceedings

  • Science

author list (cited authors)

  • Juva, K., Prockop, D. J., Cooper, G. W., & Lash, J. W.

citation count

  • 165

complete list of authors

  • Juva, K||Prockop, DJ||Cooper, GW||Lash, JW

publication date

  • April 1966