Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum. uri icon

abstract

  • Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate.

published proceedings

  • Science

author list (cited authors)

  • Uitto, J., Hoffman, H., & Prockop, D. J.

citation count

  • 41

complete list of authors

  • Uitto, J||Hoffman, H||Prockop, DJ

publication date

  • December 1975