Marrow stromal cells as stem cells for nonhematopoietic tissues. Academic Article

abstract

• Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

authors

• Prockop, Darwin

published proceedings

• Science

altmetric score

• 12

author list (cited authors)

• Prockop, D. J.

citation count

• 3926

complete list of authors

• Prockop, DJ

publication date

• April 1997

publisher

• American Association for the Advancement of Science (AAAS)  Publisher

published in

• Science  Journal

keywords

• Adipocytes
• Animals
• Bone Marrow Cells
• Bone Marrow Transplantation
• Cartilage
• Cell Differentiation
• Cells, Cultured
• Cytokines
• Genetic Therapy
• Humans
• Muscle Fibers, Skeletal
• Osteoblasts
• Stem Cells
• Stromal Cells

PubMed Central ID

• 9082988

Digital Object Identifier (DOI)

• 10.1126/science.276.5309.71

start page

• 71

end page

• 74

volume

• 276

issue

• 5309

URL

• http://dx.doi.org/10.1126/science.276.5309.71