Mitochondrial transfer between cells can rescue aerobic respiration. Academic Article

abstract

• Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.

authors

• Prockop, Darwin

published proceedings

• Proc Natl Acad Sci U S A

altmetric score

• 57.664

author list (cited authors)

• Spees, J. L., Olson, S. D., Whitney, M. J., & Prockop, D. J.

citation count

• 654

complete list of authors

• Spees, Jeffrey L||Olson, Scott D||Whitney, Mandolin J||Prockop, Darwin J

publication date

• January 2006

publisher

• Proceedings of the National Academy of Sciences  Publisher

published in

• Proceedings of the National Academy of Sciences of the United States of America  Journal

keywords

• Animals
• Bone Marrow Cells
• Cell Line
• Cell Line, Tumor
• Cells, Cultured
• Coculture Techniques
• Culture Media
• DNA, Mitochondrial
• Fibroblasts
• Genetic Therapy
• Genome
• Green Fluorescent Proteins
• Humans
• Ischemia
• Mitochondria
• Models, Genetic
• Oxygen Consumption
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide
• Protein Biosynthesis
• Protein Transport
• Stem Cells
• Time Factors

PubMed Central ID

• 16432190

Digital Object Identifier (DOI)

• 10.1073/pnas.0510511103

start page

• 1283

end page

• 1288

volume

• 103

issue

• 5

URL

• http://dx.doi.org/10.1073/pnas.0510511103