Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells. Academic Article uri icon

abstract

  • Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe(-/-)) mice were implanted into the cerebral ventricles of Apoe(-/-) mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.

published proceedings

  • Exp Neurol

author list (cited authors)

  • Peister, A., Zeitouni, S., Pfankuch, T., Reger, R. L., Prockop, D. J., & Raber, J.

citation count

  • 18

complete list of authors

  • Peister, Alexandra||Zeitouni, Suzanne||Pfankuch, Timothy||Reger, Roxanne L||Prockop, Darwin J||Raber, Jacob

publication date

  • January 2006