"Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs). Academic Article

abstract

• There has recently been an explosion of interest in adult stem/progenitor cells that have the potential to repair tissues, with over 3,000 citations to publications (PubMed) and numerous announcements of clinical trials in which the cells are used to treat individuals with a broad range of diseases. At the same time, the data present a paradox-the cells originally attracted attention because of their stem-cell-like properties, but the cells frequently repair injured tissues without much evidence of either engraftment or differentiation.

authors

• Prockop, Darwin

published proceedings

• Clin Pharmacol Ther

author list (cited authors)

• Prockop, D. J.

citation count

• 255

complete list of authors

• Prockop, DJ

publication date

• January 2007

publisher

• Springer Nature  Publisher

published in

• Clinical Pharmacology and Therapeutics  Journal

keywords

• Animals
• Cell Differentiation
• Coculture Techniques
• Humans
• Mesenchymal Stem Cell Transplantation
• Mesenchymal Stem Cells
• Multipotent Stem Cells
• Stromal Cells

Digital Object Identifier (DOI)

• 10.1038/sj.clpt.6100313

start page

• 241

end page

• 243

volume

• 82

issue

• 3

URL

• http://dx.doi.org/10.1038/sj.clpt.6100313