Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells. Academic Article

abstract

• Fibrosis and scarring are the end stage of many disease processes. In effect, the collagen fibers that initially provide a necessary strength during the repair of injured tissues are frequently synthesized in excessive amounts and become irreversible fibrotic deposits that limit regeneration of the endogenous cells of a tissue. This review will focus on the potential of mesenchymal stem/stromal cells for treatment of fibrotic diseases, with emphasis on the role of TSG-6 as a mediator of anti-inflammatory effects.

published proceedings

• Matrix Biol

altmetric score

• 1.25

author list (cited authors)

• Prockop, D. J.

citation count

• 67

complete list of authors

• Prockop, Darwin J

publication date

• January 2016

publisher

• Elsevier  Publisher

published in

• Matrix Biology  Journal

keywords

• Cell Adhesion Molecules
• Cell- And Tissue-Based Therapy
• Cicatrix
• Collagen
• Fibrosis
• Humans
• Inflammation
• Mesenchymal Stem Cell Transplantation
• Mesenchymal Stem/stromal Cells
• Regeneration
• Regenerative Medicine
• TSG-6
• Tissue Fibrosis

Digital Object Identifier (DOI)

• 10.1016/j.matbio.2016.01.010

start page

• 7

end page

• 13

volume

• 51

URL

• http://dx.doi.org/10.1016/j.matbio.2016.01.010