Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells. Academic Article uri icon

abstract

  • Fibrosis and scarring are the end stage of many disease processes. In effect, the collagen fibers that initially provide a necessary strength during the repair of injured tissues are frequently synthesized in excessive amounts and become irreversible fibrotic deposits that limit regeneration of the endogenous cells of a tissue. This review will focus on the potential of mesenchymal stem/stromal cells for treatment of fibrotic diseases, with emphasis on the role of TSG-6 as a mediator of anti-inflammatory effects.

published proceedings

  • Matrix Biol

altmetric score

  • 1.25

author list (cited authors)

  • Prockop, D. J

citation count

  • 65

complete list of authors

  • Prockop, Darwin J

publication date

  • April 2016