The effect of serotonergic agents on haloperidol-induced catalepsy. Academic Article

abstract

• The effect of various classes of serotonergic agents on haloperidol-induced catalepsy was evaluated in male Sprague-Dawley rats. The 5-HT-1A agonists buspirone, ipsapirone and 8-OH-DPAT all potently reversed catalepsy. The mixed 5-HT-1A and 5-HT-1B agonist RU 24969 reversed catalepsy only at the highest dose tested. The non-selective 5-HT-1 antagonist (l)-propranolol did not affect catalepsy. The 5-HT-2 agonist DOI and 5-HT-2 antagonist mesulergine both reversed catalepsy. ICS 205-930 (5-HT-3 antagonist) reversed catalepsy at low doses only. Another 5-HT-3 antagonist, GR 38032F, had no effect on catalepsy. These studies suggest that 5-HT-1A and 5-HT-2 receptor sites are important in the serotonergic modulation of haloperidol-induced catalepsy.

authors

• Hicks, Paul

published proceedings

• Life Sci

altmetric score

• 3

author list (cited authors)

• Hicks, P. B.

citation count

• 103

complete list of authors

• Hicks, PB

publication date

• January 1990

publisher

• Elsevier  Publisher

published in

• LIFE SCIENCES  Journal

keywords

• Animals
• Catalepsy
• Dopamine
• Haloperidol
• Male
• Rats
• Rats, Inbred Strains
• Receptors, Serotonin
• Serotonin
• Serotonin Antagonists

Digital Object Identifier (DOI)

• 10.1016/0024-3205(90)90365-x

start page

• 1609

end page

• 1615

volume

• 47

issue

• 18

URL

• http://dx.doi.org/10.1016/0024-3205(90)90365-x