Application of Atomic Force Microscopy Measurements on Cardiovascular Cells Chapter

abstract

• The atomic force microscope (AFM) is a state-of-the-art tool that can analyze and characterize samples on a scale from angstroms to 100 m by physical interaction between AFM cantilever tip and sample surface. AFM imaging has been used incrementally over last decade in living cells in cardiovascular research. Beyond its high resolution 3D imaging, AFM allows the quantitative assessments on the structure and function of the underlying cytoskeleton and cell organelles, binding probability, adhesion forces, and micromechanical properties of the cell by sensing the cell surface with mechanical sharp cantilever tip. AFM measurements have enhanced our understanding of cell mechanics in normal physiological and pathological states.

authors

• Wu, Xin

author list (cited authors)

• Wu, X., Sun, Z., Meininger, G. A., & Muthuchamy, M.

citation count

• 13

complete list of authors

• Wu, X||Sun, Z||Meininger, GA||Muthuchamy, M

editor list (cited editors)

• Peng, X., & Antonyak, M.

Book Title

• Cardiovascular Development Methods and Protocols

publication date

• January 2012

publisher

• Humana Press  Publisher

keywords

• Atomic Force Microscopy
• Cardiomyocytes
• Cell Culture
• Mechanotransduction
• Science
• Vascular Endothelial Cells
• Vascular Smooth Muscle Cells

Digital Object Identifier (DOI)

• 10.1007/978-1-61779-523-7_22

International Standard Book Number (ISBN) 10

• 1617795224

International Standard Book Number (ISBN) 13

• 9781617795220

start page

• 229

end page

• 244

volume

• 843

URL

• http://link.springer.com/protocol/10.1007/978-1-61779-523-7_22