Managing biological complexity across orthologs with a visual knowledgebase of documented biomolecular interactions. Academic Article

abstract

• The complexity of biomolecular interactions and influences is a major obstacle to their comprehension and elucidation. Visualizing knowledge of biomolecular interactions increases comprehension and facilitates the development of new hypotheses. The rapidly changing landscape of high-content experimental results also presents a challenge for the maintenance of comprehensive knowledgebases. Distributing the responsibility for maintenance of a knowledgebase to a community of subject matter experts is an effective strategy for large, complex and rapidly changing knowledgebases. Cognoscente serves these needs by building visualizations for queries of biomolecular interactions on demand, by managing the complexity of those visualizations, and by crowdsourcing to promote the incorporation of current knowledge from the literature.

authors

• VanBuren, Vincent

published proceedings

• Sci Rep

altmetric score

• 15.15

author list (cited authors)

• Vanburen, V., & Chen, H.

citation count

• 5

complete list of authors

• Vanburen, Vincent||Chen, Hailin

publication date

• January 2012

publisher

• Springer Nature  Publisher

published in

• Scientific Reports  Journal

keywords

• Biochemical Phenomena
• Biological Phenomena
• Databases, Factual
• Internet
• Knowledge Bases
• Systems Biology

Digital Object Identifier (DOI)

• 10.1038/srep01011

URI

• https://hdl.handle.net/1969.1/182669

start page

• 1011

volume

• 2

issue

• 1

URL

• http://dx.doi.org/10.1038/srep01011