Comparison of ubiquinol and cytochrome c terminal oxidases. An alternative view. Academic Article uri icon


  • There have been numerous instances in the recent literature where the properties of ubiquinol and cytochrome c terminal oxidases are compared. Here we specifically examine the cytochrome bo3-type ubiquinol oxidase from Escherichia coli and the cytochrome aa3-type cytochrome c oxidases. A second redox-active copper site (CuA) is present only in the cytochrome c oxidases and the physiological electron donors for the two enzymes are different (ubiquinol-8 vs. ferrocytochrome c). In our opinion, these differences are significant and most likely indicate that distinct turnover mechanisms are operative in the two enzymes.

published proceedings

  • FEBS Lett

author list (cited authors)

  • Musser, S. M., Stowell, M. H., & Chan, S. I.

citation count

  • 37

complete list of authors

  • Musser, SM||Stowell, MH||Chan, SI

publication date

  • July 1993