Water Soluble Metal-organic Frameworks for Pesticide Hydrolysis
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Herein, we propose to prepare a series of water-soluble Metal Organic Framework Materials for hydrolysis of organophosphate based pesticides. The MOFs will be solubilized in water by covalently attaching polar and water soluble polyethylene glycol oligomers to their orgalic linkers through azide-alkyne cycloaddition reaction. To achieve this we will prepare azide-functionalized derivatives of UiO-66 and UiO-67 MOFs and alkyne terminated PEG oligomers that can undergo click reaction with each other. We will use this water solubilized MOF materials to catalyze the hydrolysis of organophosphate based pesticide methyl-paraoxon. The kinetics of these hydrolysis reactions will be monitored by UV-Vis spectroscopy and compared to those of the parent non-soluble MOFs. During the course of this work we hope to develop methods for facile solubilization of MOF nanoparticles in polar solvents and test the effect of solubilizing heterogeneous nanoparticle catalysts on the catalytic activity.