Protein synthesis in cells infected by murine hepatitis viruses JHM and A59: tryptic peptide analysis. Academic Article

abstract

• The structural and intracellular proteins of the murine hepatitis viruses MHV-JHM and MHV-A59 were studied by tryptic peptide mapping. The results demonstrated that the virions contained three distinct proteins: the two related chains of the E2 complex, the nucleocapsid protein and the heterogeneous E1 complex. Five distinct virus-specific proteins were synthesized by infected cells. Three of the five intracellular proteins contained tryptic-peptides with properties similar to the three structural proteins. Models describing the evolution of the proteins are proposed. Although the pathogenic properties of MHV-JHM and MHV-A59 differ greatly, the tryptic peptide maps of the corresponding proteins of these MHV strains were remarkably similar.

authors

• Leibowitz, Julian

published proceedings

• Arch Virol

author list (cited authors)

• Bond, C. W., Anderson, K., & Leibowitz, J. L.

citation count

• 7

complete list of authors

• Bond, CW||Anderson, K||Leibowitz, JL

publication date

• December 1984

publisher

• Springer Nature  Publisher

published in

• Archives of Virology  Journal

keywords

• Electrophoresis, Polyacrylamide Gel
• Murine Hepatitis Virus
• Peptides
• Species Specificity
• Viral Proteins
• Viral Structural Proteins

Digital Object Identifier (DOI)

• 10.1007/BF01311223

start page

• 333

end page

• 347

volume

• 80

issue

• 4

URL

• http://dx.doi.org/10.1007/bf01311223