Genetic analysis of murine hepatitis virus strain JHM. Academic Article

abstract

• We performed a genetic analysis of 37 temperature-sensitive mutants of murine hepatitis virus strain JHM. Of our mutants, 32 did not induce murine hepatitis virus-specific RNA synthesis in infected cells at the restrictive temperature, 39 degrees C. By complementation testing we have identified at least seven nonoverlapping complementation groups. Six of the genes identified in this way are required for murine hepatitis virus-specific RNA synthesis. The seventh complementation group is made up of five mutants which induced virus-specific RNA synthesis at 39 degrees C.

authors

• Leibowitz, Julian

published proceedings

• J Virol

author list (cited authors)

• Leibowitz, J. L., DeVries, J. R., & Haspel, M. V.

citation count

• 39

complete list of authors

• Leibowitz, JL||DeVries, JR||Haspel, MV

publication date

• June 1982

publisher

• American Society for Microbiology  Publisher

published in

• Journal of Virology  Journal

keywords

• Electrophoresis, Agar Gel
• Genes, Viral
• Genetic Complementation Test
• Murine Hepatitis Virus
• Mutation
• RNA, Viral
• Temperature

PubMed Central ID

• 6284988

Digital Object Identifier (DOI)

• 10.1128/JVI.42.3.1080-1087.1982

start page

• 1080

end page

• 1087

volume

• 42

issue

• 3

URL

• http://dx.doi.org/10.1128/jvi.42.3.1080-1087.1982