Regulation of Drosophila lifespan by JNK signaling. Academic Article

abstract

• Cellular responses to extrinsic and intrinsic insults have to be carefully regulated to properly coordinate cytoprotection, repair processes, cell proliferation and apoptosis. Stress signaling pathways, most prominently the Jun-N-terminal Kinase (JNK) pathway, are critical regulators of such cellular responses and have accordingly been implicated in the regulation of lifespan in various organisms. JNK signaling promotes cytoprotective gene expression, but also interacts with the insulin signaling pathway to influence growth, metabolism, stress tolerance and regeneration. Here, we review recent studies in Drosophila that elucidate the tissue-specific and systemic consequences of JNK activation that ultimately impact lifespan of the organism.

authors

• Karpac, Jason

published proceedings

• Exp Gerontol

author list (cited authors)

• Biteau, B., Karpac, J., Hwangbo, D., & Jasper, H.

citation count

• 94

complete list of authors

• Biteau, Benoit||Karpac, Jason||Hwangbo, Daesung||Jasper, Heinrich

publication date

• May 2011

publisher

• Elsevier  Publisher

published in

• Experimental Gerontology  Journal

keywords

• Aging
• Animals
• Drosophila Melanogaster
• JNK Mitogen-Activated Protein Kinases
• Longevity
• Models, Animal
• Signal Transduction

Digital Object Identifier (DOI)

• 10.1016/j.exger.2010.11.003

start page

• 349

end page

• 354

volume

• 46

issue

• 5

URL

• http://dx.doi.org/10.1016/j.exger.2010.11.003