Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia. Academic Article uri icon

abstract

  • In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.

published proceedings

  • Leuk Res

author list (cited authors)

  • Hayes, T. G., Tan, X. L., Moseley, A. B., Huston, M. M., & Huston, D. P

citation count

  • 3

complete list of authors

  • Hayes, TG||Tan, XL||Moseley, AB||Huston, MM||Huston, DP

publication date

  • September 1993