Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia.

abstract

• In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.

authors

• Huston, David

published proceedings

• Leuk Res

author list (cited authors)

• Hayes, T. G., Tan, X. L., Moseley, A. B., Huston, M. M., & Huston, D. P.

citation count

• 3

complete list of authors

• Hayes, TG||Tan, XL||Moseley, AB||Huston, MM||Huston, DP

publication date

• January 1993

publisher

• Elsevier  Publisher

published in

• Leukemia Research  Journal

keywords

• Cell Division
• Humans
• Immunoglobulin M
• Interleukin-2
• Interleukin-5
• Leukemia, Lymphocytic, Chronic, B-Cell
• Mitogens
• Recombinant Proteins
• Tumor Cells, Cultured

Digital Object Identifier (DOI)

• 10.1016/0145-2126(93)90112-x

start page

• 777

end page

• 783

volume

• 17

issue

• 9

URL

• http://dx.doi.org/10.1016/0145-2126(93)90112-x