Primary cell-mediated lympholysis response to a maternally transmitted antigen. Academic Article

abstract

• Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 X NZB)F1, but not from the reciprocal Mta- F1, thus demonstrating H-2-unrestricted lysis of Mta.

authors

• Huston, David

published proceedings

• J Exp Med

author list (cited authors)

• Smith, R., Huston, D. P., & Rich, R. R.

citation count

• 8

complete list of authors

• Smith, R||Huston, DP||Rich, RR

publication date

• December 1982

publisher

• Rockefeller University Press  Publisher

published in

• Journal of Experimental Medicine (JEM)  Journal

keywords

• Animals
• Cytotoxicity, Immunologic
• Female
• H-2 Antigens
• Immunity, Cellular
• Immunity, Maternally-Acquired
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Mice, Inbred NZB
• T-Lymphocytes, Cytotoxic

PubMed Central ID

• 6983563

Digital Object Identifier (DOI)

• 10.1084/jem.156.6.1866

start page

• 1866

end page

• 1871

volume

• 156

issue

• 6

URL

• http://dx.doi.org/10.1084/jem.156.6.1866