Primary cell-mediated lympholysis response to a maternally transmitted antigen. Academic Article uri icon


  • Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 X NZB)F1, but not from the reciprocal Mta- F1, thus demonstrating H-2-unrestricted lysis of Mta.

published proceedings

  • J Exp Med

author list (cited authors)

  • Smith, R., Huston, D. P., & Rich, R. R.

citation count

  • 8

complete list of authors

  • Smith, R||Huston, DP||Rich, RR

publication date

  • December 1982