Subcutaneous nodular amyloidosis: a case report and review of the literature.

abstract

• Amyloidosis typically manifests with disseminated infiltration of multiple organ systems. Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck nodules. Immunohistochemical analysis showed the amyloid deposits to be derived from lambda light chains. Twenty-four month follow-up showed minimal disease progression. A literature review showed only 5 reported cases of subcutaneous nodular amyloidosis. This is the first description of a patient with subcutaneous nodular amyloidosis derived from lambda light chains. HUM PATHOL 32:346-348.

authors

• Huston, David

published proceedings

• Hum Pathol

author list (cited authors)

• Nguyen, T. U., Oghalai, J. S., McGregor, D. K., Janssen, N. M., & Huston, D. P.

citation count

• 15

complete list of authors

• Nguyen, TU||Oghalai, JS||McGregor, DK||Janssen, NM||Huston, DP

publication date

• January 2001

publisher

• Elsevier  Publisher

published in

• Human Pathology  Journal

keywords

• Adult
• Amyloid
• Amyloidosis
• Antibodies, Monoclonal
• Bence Jones Protein
• Biopsy
• Female
• Humans
• Immunoglobulin Lambda-Chains
• Immunoglobulin M
• Immunohistochemistry
• Male
• Middle Aged
• Muscle, Skeletal
• Neck
• Proteinuria
• Tomography, X-Ray Computed

Digital Object Identifier (DOI)

• 10.1053/hupa.2001.22742

start page

• 346

end page

• 348

volume

• 32

issue

• 3

URL

• http://dx.doi.org/10.1053/hupa.2001.22742