Sequence homologies near the C-termini of the variable surface glycoproteins of Trypanosoma brucei Academic Article uri icon

abstract

  • African trypanosomes evade their mammalian host's immune system by the sequential expression of alternative surface glycoproteins. Comparison of the cDNA sequences of five antigenically distinct surface proteins and the C-terminal amino acid sequences of four additional ones demonstrates that these nine glycoproteins can be classified into two subsets based on C-terminal amino acid homologies that extend 75-105 amino acids into the protein. © 1981 Nature Publishing Group.

author list (cited authors)

  • Rice-Ficht, A. C., Chen, K. K., & Donelson, J. E.

citation count

  • 106

publication date

  • November 1981

published in