Use of helper T cells to identify potential vaccine antigens of Babesia bovis. Academic Article uri icon


  • Babesia bovis is an economically important hemoprotozoon parasite o f cattle that is prevalent in many, tropical and subtropical regions o f the world. Effective vaccines against this tick-transmitted parasite consist o f live organisms attenuated by passage through splenectomized calves. However, the nature o f acquired resistance to challenge infection with heterologous isolates of this parasite has not been clearly defined. Unsuccessful attempts to select protective antigens have relied upon the use of antibodies to identify immunodominant proteins. In this review, Wendy Brown and Allison Rice-Ficht discuss the limitations of this approach and the rationale behind using helper T cells to select potential vaccine antigens.

published proceedings

  • Parasitol Today

author list (cited authors)

  • Brown, W. C., & Rice-Ficht, A. C.

citation count

  • 33

complete list of authors

  • Brown, WC||Rice-Ficht, AC

publication date

  • April 1994