Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro. Academic Article uri icon


  • A culture system was developed to study intrinsic oscillations within rat suprachiasmatic nuclei for long periods of time. After isolation in static organ cultures, individual rat suprachiasmatic explants released vasopressin in a circadian fashion for at least 4 cycles. This finding suggests that the suprachiasmatic nucleus contains one or more self-sustained circadian oscillators, and that this method of measuring circadian rhythms from individual suprachiasmatic organ cultures may prove to be a valuable model for elucidating the physiology and biochemistry of mammalian circadian pacemakers.

published proceedings

  • Brain Res

author list (cited authors)

  • Earnest, D. J., & Sladek, C. D.

citation count

  • 171

complete list of authors

  • Earnest, DJ||Sladek, CD

publication date

  • September 1986